KEGG   PATHWAY: ko04151
Entry
ko04151                     Pathway                                
Name
PI3K-Akt signaling pathway
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04151  PI3K-Akt signaling pathway
ko04151

Other DBs
GO: 0043491
Orthology
K00693  GYS; glycogen synthase [EC:2.4.1.11]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01084  G6PC; glucose-6-phosphatase [EC:3.1.3.9]
K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K01596  E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]
K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091  CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K02158  BAD; Bcl-2-antagonist of cell death
K02161  BCL2; apoptosis regulator Bcl-2
K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02539  MCL1; myeloid leukemia cell differntiation protein MCL-1
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02582  NGFB; nerve growth factor, beta
K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K02833  HRAS; GTPase HRas
K02991  RP-S6e, RPS6; small subunit ribosomal protein S6e
K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03099  SOS; son of sevenless
K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K03258  EIF4B; translation initiation factor 4B
K03259  EIF4E; translation initiation factor 4E
K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K03900  VWF; von Willebrand factor
K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
K04079  HSP90A, htpG; molecular chaperone HtpG
K04129  CHRM1; muscarinic acetylcholine receptor M1
K04130  CHRM2; muscarinic acetylcholine receptor M2
K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
K04347  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04355  BDNF; brain-derived neurotrophic factor
K04356  NTF3; neurotrophin 3
K04357  EGF; epidermal growth factor
K04358  FGF; fibroblast growth factor
K04359  PDGFA; platelet-derived growth factor subunit A
K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
K04361  EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]
K04362  FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]
K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha [EC:2.7.10.1]
K04364  GRB2; growth factor receptor-bound protein 2
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04377  MYC; Myc proto-oncogene protein
K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04399  CASP9; caspase 9 [EC:3.4.22.62]
K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451  TP53, P53; tumor protein p53
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04465  NR4A1, HMR; nuclear receptor subfamily 4 group A member 1
K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K04503  CCND1; G1/S-specific cyclin-D1
K04526  INS; insulin
K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
K04536  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K04538  GNB4; guanine nucleotide-binding protein subunit beta-4
K04539  GNB5; guanine nucleotide-binding protein subunit beta-5
K04540  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04547  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04659  THBS2S; thrombospondin 2/3/4/5
K04688  RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]
K04735  RELA; transcription factor p65
K04736  IL3; interleukin 3
K04737  IL3RA, CD123; interleukin 3 receptor alpha
K05055  IL6R, CD126; interleukin 6 receptor
K05057  OSMR; oncostatin M receptor
K05061  CSF3R, CD114; granulocyte colony-stimulating factor receptor
K05068  IL2RA, CD25; interleukin 2 receptor alpha
K05069  IL2RB, CD122; interleukin 2 receptor beta
K05070  IL2RG, CD132; interleukin 2 receptor gamma
K05071  IL4R, CD124; interleukin 4 receptor
K05072  IL7R, CD127; interleukin 7 receptor
K05079  EPOR; erythropoietin receptor
K05080  GHR; growth hormone receptor
K05081  PRLR; prolactin receptor
K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
K05087  IGF1R, CD221; insulin-like growth factor 1 receptor [EC:2.7.10.1]
K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]
K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05091  KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]
K05093  FGFR2, CD332; fibroblast growth factor receptor 2 [EC:2.7.10.1]
K05094  FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]
K05095  FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]
K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]
K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4 [EC:2.7.10.1]
K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]
K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K05103  EPHA2, ECK; Eph receptor A2 [EC:2.7.10.1]
K05121  TEK, TIE2, CD202; endothelial-specific receptor tyrosine kinase [EC:2.7.10.1]
K05126  RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
K05130  IFNAR1; interferon receptor 1
K05131  IFNAR2; interferon receptor 2
K05405  IL6; interleukin 6
K05414  IFNA; interferon alpha
K05415  IFNB; interferon beta
K05418  OSM; oncostatin M
K05423  CSF3, GCSF; granulocyte colony-stimulating factor
K05429  IL2; interleukin 2
K05430  IL4; interleukin 4
K05431  IL7; interleukin 7
K05437  EPO; erythropoietin
K05438  GH; growth hormone
K05439  PRL; prolactin
K05448  VEGFA; vascular endothelial growth factor A
K05449  VEGFC_D; vascular endothelial growth factor C/D
K05450  PDGFC_D; platelet derived growth factor C/D
K05451  NGFA; nerve growth factor, alpha
K05452  GDNF; glial cell derived neurotrophic factor
K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
K05454  FLT3LG; fms-related tyrosine kinase 3 ligand
K05459  IGF1; insulin-like growth factor 1
K05460  HGF; hepatocyte growth factor
K05461  KITLG; KIT ligand
K05462  EFNA; ephrin-A
K05465  ANGPT1; angiopoietin 1
K05466  ANGPT2; angiopoietin 2
K05467  ANGPT4; angiopoietin 4
K05629  AIP1; atrophin-1 interacting protein 1
K05631  AIP3, WWP3, BAIAP1; atrophin-1 interacting protein 3 (BAI1-associated protein 1)
K05635  LAMC1; laminin, gamma 1
K05636  LAMB1; laminin, beta 1
K05637  LAMA1_2; laminin, alpha 1/2
K05717  FN1; fibronectin 1
K05719  ITGB1, CD29; integrin beta 1
K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K06071  PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]
K06236  COL1A; collagen type I alpha
K06237  COL4A; collagen type IV alpha
K06238  COL6A; collagen type VI alpha
K06240  LAMA3_5; laminin, alpha 3/5
K06241  LAMA4; laminin, alpha 4
K06243  LAMB2; laminin, beta 2
K06244  LAMB3; laminin, beta 3
K06245  LAMB4; laminin, beta 4
K06246  LAMC2; laminin, gamma 2
K06247  LAMC3; laminin, gamma 3
K06248  CHAD; chondroadherin
K06249  RELN; reelin [EC:3.4.21.-]
K06250  SPP1, BNSP, OPN; secreted phosphoprotein 1
K06251  VTN; vitronectin
K06252  TN; tenascin
K06253  IBSP; integrin binding sialoprotein
K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K06465  CD19; B-lymphocyte antigen CD19
K06476  ITGA2B, CD41; integrin alpha 2B
K06480  ITGA1, CD49a; integrin alpha 1
K06481  ITGA2, CD49b; integrin alpha 2
K06482  ITGA3, CD49c; integrin alpha 3
K06483  ITGA4, CD49d; integrin alpha 4
K06484  ITGA5, CD49e; integrin alpha 5
K06485  ITGA6, CD49f; integrin alpha 6
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06525  ITGB4, CD104; integrin beta 4
K06583  ITGA7; integrin alpha 7
K06584  ITGA8; integrin alpha 8
K06585  ITGA9; integrin alpha 9
K06586  ITGA10; integrin alpha 10
K06587  ITGA11; integrin alpha 11
K06588  ITGB5; integrin beta 5
K06589  ITGB6; integrin beta 6
K06590  ITGB7; integrin beta 7
K06591  ITGB8; integrin beta 8
K06624  CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626  CCNE; G1/S-specific cyclin-E1
K06630  YWHAE; 14-3-3 protein epsilon
K06643  MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K06856  IGH; immunoglobulin heavy chain
K07198  PRKAA, AMPK; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07204  RAPTOR; regulatory associated protein of mTOR
K07205  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
K07206  TSC1; tuberous sclerosis 1
K07207  TSC2; tuberous sclerosis 2
K07208  RHEB; Ras homolog enriched in brain
K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07298  STK11, LKB1; serine/threonine-protein kinase 11 [EC:2.7.11.1]
K07825  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K07826  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K08131  COL9A; collagen type IX alpha
K08266  MLST8, GBL; target of rapamycin complex subunit LST8
K08270  DDIT4, REDD1; DNA-damage-inducible transcript 4
K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
K08524  RXRA, NR2B1; retinoid X receptor alpha
K08774  TGFA; transforming growth factor, alpha
K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K09048  CREB3; cyclic AMP-responsive element-binding protein 3
K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
K09408  FOXO3; forkhead box protein O3
K09420  MYB, C-MYB; transcriptional activator Myb
K09487  HSP90B, TRA1; heat shock protein 90kDa beta
K09554  CDC37; cell division cycle protein 37
K09782  AREG; amphiregulin
K09784  EREG; epiregulin
K10151  CCND2; G1/S-specific cyclin-D2
K10152  CCND3; G1/S-specific cyclin-D3
K10159  TLR2, CD282; toll-like receptor 2
K10160  TLR4, CD284; toll-like receptor 4
K10167  TCL1A; T-cell leukemia/lymphoma 1A
K10605  BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K12230  PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1
K12457  NTF4; neurotrophin 4
K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
K13303  SGK2; serum/glucocorticoid-regulated kinase 2 [EC:2.7.11.1]
K13304  SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]
K13769  IGF2; insulin-like growth factor 2
K16172  IRS1; insulin receptor substrate 1
K16197  YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16198  YWHAG_H; 14-3-3 protein gamma/eta
K16332  RBL2; retinoblastoma-like protein 2
K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
K16339  THEM4, CTMP; acyl-coenzyme A thioesterase THEM4 [EC:3.1.2.2]
K16340  PHLPP; PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
K16341  BCL2L11, BIM; Bcl-2-like protein 11
K16836  TCL1B; T-cell leukemia/lymphoma 1B
K16837  MTCP1; mature T-cell proliferation-1 type B1
K16857  THBS1; thrombospondin 1
K16858  VEGFB; vascular endothelial growth factor B
K16859  PGF; placenta growth factor
K17386  PDGFB; platelet-derived growth factor subunit B
K18496  FGF1; fibroblast growth factor 1
K18497  FGF2; fibroblast growth factor 2
K19719  COL2A; collagen type II alpha
K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
K22428  FGF23; fibroblast growth factor 23
K22429  FGF21; fibroblast growth factor 21
K22603  FGF19; fibroblast growth factor 19
K23691  PKN2; serine/threonine-protein kinase N2
K23692  PKN3; serine/threonine-protein kinase N3
K25414  NRTN; neurturin
K25415  ARTN; artemin
K25416  PSPN; persephin
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04210  Apoptosis
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04620  Toll-like receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04662  B cell receptor signaling pathway
ko04910  Insulin signaling pathway

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