Entry Name Hematopoietic cell lineage
Description Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Orthology K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K04006 DAF, CD55; decay accelerating factor
K04011 CR1, CD35; complement component (3b/4b) receptor 1
K04012 CR2, CD21; complement receptor type 2
K04383 IL1A; interleukin 1 alpha
K04386 IL1R1, CD121a; interleukin 1 receptor type I
K04387 IL1R2, CD121b; interleukin 1 receptor type II
K04391 CD14; monocyte differentiation antigen CD14
K04519 IL1B; interleukin 1 beta
K04737 IL3RA, CD123; interleukin 3 receptor alpha
K05055 IL6R, CD126; interleukin 6 receptor
K05056 IL11RA; interleukin 11 receptor alpha
K05061 CSF3R, CD114; granulocyte colony-stimulating factor receptor
K05066 CSF2RA, GMCSFR, CD116; granulocyte-macrophage colony-stimulating factor receptor alpha
K05067 IL5RA, CD125; interleukin 5 receptor alpha
K05068 IL2RA, CD25; interleukin 2 receptor alpha
K05071 IL4R, CD124; interleukin 4 receptor
K05072 IL7R, CD127; interleukin 7 receptor
K05073 IL9R, CD129; interleukin 9 receptor
K05079 EPOR; erythropoietin receptor
K05090 CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1 ]
K05091 KIT, SCFR, CD117; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1 ]
K05423 CSF3, GCSF; granulocyte colony-stimulating factor
K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K05453 CSF1, MCSF; macrophage colony-stimulating factor 1
K05454 FLT3LG; fms-related tyrosine kinase 3 ligand
K06260 GP5, CD42d; platelet glycoprotein V
K06261 GP1BA, CD42b; platelet glycoprotein Ib alpha chain
K06262 GP1BB, CD42c; platelet glycoprotein Ib beta chain
K06263 GP9, CD42a; platelet glycoprotein IX
K06448 CD1; T-cell surface glycoprotein CD1
K06449 CD2; T-cell surface glycoprotein CD2
K06450 CD3D; T-cell surface glycoprotein CD3 delta chain
K06451 CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452 CD3G; T-cell surface glycoprotein CD3 gamma chain
K06454 CD4; T-cell surface glycoprotein CD4
K06455 CD5; T-cell surface glycoprotein CD5
K06457 CD7; T-cell surface glycoprotein CD7
K06458 CD8A; T-cell surface glycoprotein CD8 alpha chain
K06459 CD8B; T-cell surface glycoprotein CD8 beta chain
K06460 CD9, TSPAN29; CD9 antigen
K06461 ITGAM, CD11b; integrin alpha M
K06465 CD19; B-lymphocyte antigen CD19
K06466 MS4A1, CD20; B-lymphocyte antigen CD20
K06467 CD22, SIGLEC2; CD22 antigen
K06468 FCER2, CD23; low affinity immunoglobulin epsilon Fc receptor
K06473 CD33, SIGLEC3; CD33 antigen
K06475 CD37, TSPAN26; CD37 antigen
K06476 ITGA2B, CD41; integrin alpha 2B
K06480 ITGA1, CD49a; integrin alpha 1
K06481 ITGA2, CD49b; integrin alpha 2
K06482 ITGA3, CD49c; integrin alpha 3
K06483 ITGA4, CD49d; integrin alpha 4
K06484 ITGA5, CD49e; integrin alpha 5
K06485 ITGA6, CD49f; integrin alpha 6
K06493 ITGB3, CD61; integrin beta 3
K06498 FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
K06503 TFRC, CD71; transferrin receptor
K06575 GYPA, CD235a; glycophorin A
K06752 MHC2; MHC class II antigen
K06856 IGH; immunoglobulin heavy chain
Reference Authors Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
Title Immunobiology - International editon: The immune system in health and disease
Journal Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference Authors Abe T
Title [Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
Journal Nihonijishinhousya (2000)
Reference Authors Rothenberg EV, Taghon T.
Title Molecular genetics of T cell development.
Journal Reference Authors Ceredig R, Rolink T.
Title A positive look at double-negative thymocytes.
Journal Reference Authors de Bruijn MF, Speck NA.
Title Core-binding factors in hematopoiesis and immune function.
Journal Reference Authors Radtke F, Wilson A, Mancini SJ, MacDonald HR.
Title Notch regulation of lymphocyte development and function.
Journal Reference Authors Spits H.
Title Development of alphabeta T cells in the human thymus.
Journal Reference Authors Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
Title The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
Journal Reference Authors Mak TW, Penninger JM, Ohashi PS.
Title Knockout mice: a paradigm shift in modern immunology.
Journal Reference Authors Shapiro-Shelef M, Calame K.
Title Regulation of plasma-cell development.
Journal Reference Authors Maillard I, Adler SH, Pear WS.
Title Notch and the immune system.
Journal Reference Authors Alpdogan O, van den Brink MR.
Title IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
Journal
