KEGG   PATHWAY: lcm04070
Entry
lcm04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Latimeria chalumnae (coelacanth)
Class
Environmental Information Processing; Signal transduction
Pathway map
lcm04070  Phosphatidylinositol signaling system
lcm04070

Organism
Latimeria chalumnae (coelacanth) [GN:lcm]
Gene
102345110  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102345812  PPIP5K1; diphosphoinositol pentakisphosphate kinase 1 [KO:K13024] [EC:2.7.4.24]
102345855  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102345989  [KO:K02183]
102346025  IP6K3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
102346112  [KO:K00901] [EC:2.7.1.107]
102346551  PI4K2A; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
102346693  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
102346788  IMPAD1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7]
102346950  CDS2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
102347000  INPP5F; inositol polyphosphate-5-phosphatase F [KO:K21798] [EC:3.1.3.-]
102347032  CDS1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
102347246  CALM1; calmodulin 1 [KO:K02183]
102347584  [KO:K05861] [EC:3.1.4.11]
102347797  PLCD1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
102347853  PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
102347919  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
102348007  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102348021  INPP4B; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
102348275  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102348548  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102348562  PLCD3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
102348811  TMEM55A; transmembrane protein 55A [KO:K13084] [EC:3.1.3.78]
102349059  IMPA2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
102349094  PPIP5K2; diphosphoinositol pentakisphosphate kinase 2 [KO:K13024] [EC:2.7.4.24]
102349479  INPP5A; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
102349503  [KO:K15759] [EC:3.1.3.7]
102349621  OCRL; OCRL, inositol polyphosphate-5-phosphatase [KO:K01099] [EC:3.1.3.36]
102349777  INPP1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
102349822  [KO:K05857] [EC:3.1.4.11]
102349825  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102350126  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102350498  ITPKC; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102350667  [KO:K07756] [EC:2.7.4.21]
102350800  MTMR7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
102350948  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102351041  MTM1; myotubularin 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
102351332  [KO:K00922] [EC:2.7.1.153]
102351435  IPMK; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
102351582  [KO:K15909] [EC:3.1.3.86]
102351622  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102351625  ITPK1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
102351676  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
102352260  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102352382  MTMR1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
102352617  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102352737  PI4KA; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
102352804  [KO:K01116] [EC:3.1.4.11]
102353218  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102353717  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102353881  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
102353988  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
102354038  PI4K2B; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
102354177  PI4KB; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
102354402  PLCD4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
102355241  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
102356117  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
102356375  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
102356410  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
102357306  TMEM55B; transmembrane protein 55B [KO:K13084] [EC:3.1.3.78]
102357395  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
102357566  INPP5E; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
102357589  MTMR6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
102358132  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102359335  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102359548  IP6K1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
102359693  CALML4; calmodulin like 4 [KO:K02183]
102359711  CALM2; calmodulin 2 [KO:K02183]
102359880  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102360018  IP6K2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
102360050  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
102360413  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
102360654  INPP4A; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
102360791  [KO:K02183]
102361104  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102361286  [KO:K02183]
102361301  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102361415  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102361839  INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
102361906  SYNJ2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
102362073  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
102362364  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102362442  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102362511  [KO:K21798] [EC:3.1.3.-]
102363357  IMPA1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
102363626  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
102364090  [KO:K00901] [EC:2.7.1.107]
102364122  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
102364350  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102364570  INPP5B; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
102364971  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102365442  IPPK; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
102365542  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102365596  INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
102365794  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
102366399  [KO:K21797] [EC:3.1.3.-]
102366435  MTMR2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
102366649  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
102366716  [KO:K01106] [EC:3.1.3.56]
102366907  CALML6; calmodulin like 6 [KO:K02183]
102366969  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
102367009  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
102367128  MTMR8; myotubularin related protein 8 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
102367670  SYNJ1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
lcm04020  Calcium signaling pathway
lcm04144  Endocytosis
lcm04510  Focal adhesion
KO pathway
ko04070   

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