Entry Name Fc gamma R-mediated phagocytosis - Lutra lutra (Eurasian river otter)
Description Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map llv04666 Fc gamma R-mediated phagocytosis
Ortholog table Other DBs Organism Lutra lutra (Eurasian river otter) [GN:
llv ]
Gene 125099196 high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498 ]
125086328 low affinity immunoglobulin gamma Fc region receptor III-A [KO:K06463 ]
125096824 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125099801 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
125082268 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
125097558 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
125083440 actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
125107249 ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
125102283 wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753 ]
125096211 wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
125108360 LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488 ]
125098322 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488 ]
125099154 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488 ]
125090866 linker for activation of T-cells family member 1-like isoform X1 [KO:K07362 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C06124 Sphingosine 1-phosphate
Reference Authors Garcia-Garcia E, Rosales C
Title Signal transduction during Fc receptor-mediated phagocytosis.
Journal Reference Authors Cox D, Greenberg S
Title Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
Journal Reference Authors Swanson JA, Hoppe AD
Title The coordination of signaling during Fc receptor-mediated phagocytosis.
Journal Reference Authors Ravetch JV, Bolland S
Title IgG Fc receptors.
Journal Reference Authors Groves E, Dart AE, Covarelli V, Caron E
Title Molecular mechanisms of phagocytic uptake in mammalian cells.
Journal Reference Authors Kwiatkowska K, Sobota A
Title Signaling pathways in phagocytosis.
Journal Reference Authors Greenberg S
Title Modular components of phagocytosis.
Journal Reference Authors Lennartz MR
Title Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
Journal Reference Authors May RC, Machesky LM
Title Phagocytosis and the actin cytoskeleton.
Journal J Cell Sci 114:1061-77 (2001)
Reference Authors Joshi T, Butchar JP, Tridandapani S
Title Fcgamma receptor signaling in phagocytes.
Journal Reference Authors Lee WL, Cosio G, Ireton K, Grinstein S
Title Role of CrkII in Fcgamma receptor-mediated phagocytosis.
Journal Reference Authors Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
Title PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
Journal Reference Authors Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
Title The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
Journal Reference Authors Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
Title FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
Journal Reference Authors Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
Title Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
Journal Reference Authors Dana R, Leto TL, Malech HL, Levy R
Title Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
Journal Reference Authors Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
Title Dynamin 2 is required for phagocytosis in macrophages.
Journal Reference Authors Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
Title Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
Journal Reference Authors Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
Title Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
Journal J Immunol 163:6785-93 (1999)
Reference Authors Sanchez-Mejorada G, Rosales C
Title Signal transduction by immunoglobulin Fc receptors.
Journal Reference Authors Rosales C (ed).
Title Molecular Mechanisms of Phagocytosis
Journal Springer (2005)
Related llv04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
