KEGG   PATHWAY: loc04150
Entry
loc04150                    Pathway                                
Name
mTOR signaling pathway - Lepisosteus oculatus (spotted gar)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
loc04150  mTOR signaling pathway
loc04150

Organism
Lepisosteus oculatus (spotted gar) [GN:loc]
Gene
102682401  large neutral amino acids transporter small subunit 1-like [KO:K13780]
102695175  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
102694923  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
102694402  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102684316  atp6v1b1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
102699211  V-type proton ATPase subunit B, brain isoform [KO:K02147]
102687674  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102688426  atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
102688392  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
102689060  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
102694025  atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
102683386  atp6v1f; V-type proton ATPase subunit F isoform X1 [KO:K02151]
102693325  V-type proton ATPase subunit G 1-like [KO:K02152]
102696851  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102698675  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
102698049  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
102688711  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
102698421  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
102684910  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
102691403  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102696961  fnip2; folliculin-interacting protein 2 isoform X3 [KO:K20401]
102690405  ras-related GTP-binding protein A [KO:K16185]
102689912  rragd; ras-related GTP-binding protein D [KO:K16186]
102694605  rragc; ras-related GTP-binding protein C [KO:K16186]
102695000  sestrin-2-like [KO:K20394]
102690157  gatsl3; GATS-like protein 3 [KO:K23080]
102690099  gatsl2; GATS-like protein 2 [KO:K23081]
102696923  mios; WD repeat-containing protein mio [KO:K20407]
102684346  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
102683541  wdr24; WD repeat-containing protein 24 [KO:K20408]
102687186  wdr59; WD repeat-containing protein 59 isoform X1 [KO:K20409]
102684001  sec13; protein SEC13 homolog [KO:K14004]
102695496  DEP domain-containing protein 5-like [KO:K20404]
102697031  nprl2; nitrogen permease regulator 2-like protein [KO:K20405]
102692565  nprl3; nitrogen permease regulator 3-like protein isoform X3 [KO:K20406]
102683784  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
102686765  rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
102682722  rptor; regulatory-associated protein of mTOR [KO:K07204]
102683567  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
102692856  mtor; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102698767  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
102696535  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
102699241  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
102687448  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
102693916  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
102683621  clip1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
102697507  grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
102693990  lpin1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
102684619  lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
102691219  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
102688482  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102686648  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
102689159  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
102685148  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
102685112  eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
102697157  eukaryotic translation initiation factor 4E-like isoform X4 [KO:K03259]
102696571  eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102695696  rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102691816  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
102697935  eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102686669  rps6; 40S ribosomal protein S6 [KO:K02991]
102685010  strada; STE20-related kinase adapter protein alpha [KO:K08271]
102696861  stradb; STE20-related kinase adapter protein beta [KO:K17532]
102684679  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102689211  cab39; calcium-binding protein 39 isoform X1 [KO:K08272]
102682399  cab39l; calcium-binding protein 39-like [KO:K08272]
102696188  calcium-binding protein 39-like [KO:K08272]
102693561  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
102698529  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
102697582  hamartin-like isoform X1 [KO:K07206]
102698706  tsc2; tuberin isoform X1 [KO:K07207]
102689121  tbc1d7; TBC1 domain family member 7 [KO:K20396]
102693805  rhebl1; GTPase RhebL1 [KO:K07208]
102685538  rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
102698202  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
102694206  wnt1; proto-oncogene Wnt-1 [KO:K03209]
102689858  wnt2b; protein Wnt-2b [KO:K00182]
102684007  wnt2; protein Wnt-2 [KO:K00182]
102682191  wnt3; proto-oncogene Wnt-3 [KO:K00312]
102698349  wnt3a; protein Wnt-3a isoform X1 [KO:K00312]
102683974  wnt4; protein Wnt-4 [KO:K00408]
102698456  protein Wnt-4a-like [KO:K00408]
102695724  wnt5a; protein Wnt-5a [KO:K00444]
102694682  wnt5b; protein Wnt-5b isoform X5 [KO:K00444]
102696070  wnt6; protein Wnt-6 isoform X1 [KO:K00445]
102693948  wnt7a; protein Wnt-7a [KO:K00572]
102688251  wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
102696114  wnt8b; protein Wnt-8b isoform X1 [KO:K00714]
102687556  protein Wnt-8a-like [KO:K00714]
102691103  wnt9b; protein Wnt-9b [KO:K01064]
102691054  protein Wnt-9b-like [KO:K01064]
102698554  wnt9a; protein Wnt-9a [KO:K01064]
102689822  wnt10a; protein Wnt-10a [KO:K01357]
102694406  wnt10b; protein Wnt-10b [KO:K01357]
102685105  wnt11; protein Wnt-11 isoform X1 [KO:K01384]
102682776  protein Wnt-11-like [KO:K01384]
102687765  wnt16; protein Wnt-16 [KO:K01558]
102693510  fzd1; frizzled-1 [KO:K02432]
102685676  fzd7; frizzled-7 [KO:K02432]
102686438  fzd2; frizzled-2 [KO:K02235]
102687061  fzd3; frizzled-3 isoform X3 [KO:K02329]
102695058  fzd4; frizzled-4 [KO:K02354]
102684949  fzd5; frizzled-5 [KO:K02375]
102685982  fzd8; frizzled-8 [KO:K02375]
102692430  frizzled-6-like [KO:K02376]
102689497  fzd10; frizzled-10 [KO:K02842]
102685832  fzd9; frizzled-9 [KO:K02842]
102687318  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
102687640  lrp6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
102695382  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102688116  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
102695892  dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102692161  gsk3b; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
102690045  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102694874  insulin-like [KO:K04526]
102695073  insulin-like isoform X2 [KO:K04526]
102694945  igf1; insulin-like growth factor I isoform X3 [KO:K05459]
102696537  insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102690467  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102696581  grb2; growth factor receptor-bound protein 2 [KO:K04364]
102692301  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102696513  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102697398  hras; GTPase HRas [KO:K02833]
102696189  kras; GTPase KRas isoform X3 [KO:K07827]
102691327  nras; GTPase NRas [KO:K07828]
102693824  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102692545  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102691532  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102686784  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102683764  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102696953  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102686641  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102692752  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X4 [KO:K04373] [EC:2.7.11.1]
102691210  ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
102684310  insulin receptor substrate 2-A-like [KO:K16172]
102696987  irs1; insulin receptor substrate 1 [KO:K16172]
102693436  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
102696821  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
102687995  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
102691786  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102685070  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102688673  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102695429  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102685186  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102691100  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102690433  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102684446  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102691207  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102691336  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102690033  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
102699069  rictor; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102695273  prr5; proline-rich protein 5 isoform X1 [KO:K20411]
102683978  prr5l; proline-rich protein 5-like isoform X3 [KO:K20411]
102686749  transforming protein RhoA-like [KO:K04513]
102689455  rhoc; rho-related GTP-binding protein RhoC [KO:K04513]
102682211  rho-related GTP-binding protein RhoA-C [KO:K04513]
102683741  prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102689943  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102695315  sgk1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
102691934  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
loc00561  Glycerolipid metabolism
loc04010  MAPK signaling pathway
loc04140  Autophagy - animal
loc04810  Regulation of actin cytoskeleton
loc04910  Insulin signaling pathway
KO pathway
ko04150   
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