KEGG   PATHWAY: loc04010
Entry
loc04010                    Pathway                                
Name
MAPK signaling pathway - Lepisosteus oculatus (spotted gar)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
loc04010  MAPK signaling pathway
loc04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Lepisosteus oculatus (spotted gar) [GN:loc]
Gene
102682161  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102682229  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102682431  kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102682504  fgf8; fibroblast growth factor 8 [KO:K04358]
102682518  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
102682608  nf1; neurofibromin [KO:K08052]
102682636  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102682646  kitlg; kit ligand isoform X1 [KO:K05461]
102682723  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102682814  [KO:K13376]
102682818  [KO:K07210]
102682852  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102683057  cacng3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
102683125  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102683218  [KO:K16342] [EC:3.1.1.4]
102683228  efna5; ephrin-A5 isoform X1 [KO:K05462]
102683229  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102683325  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102683326  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102683404  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102683416  cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
102683417  dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102683467  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102683487  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102683493  tgfb2; transforming growth factor beta-2 [KO:K13376]
102683532  cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
102683591  rasgrp1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
102683684  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
102683741  prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102683764  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102683866  [KO:K05096] [EC:2.7.10.1]
102683891  [KO:K04438]
102684037  igf2; insulin-like growth factor II [KO:K13769]
102684056  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
102684078  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102684182  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102684228  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102684317  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102684341  artn; artemin [KO:K25415]
102684408  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102684410  myc; myc proto-oncogene protein [KO:K04377]
102684446  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102684448  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102684543  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
102684605  nrk; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
102684665  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102684714  fgf20; fibroblast growth factor 20 [KO:K04358]
102684734  [KO:K04421] [EC:2.7.11.25]
102684802  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
102684939  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102685060  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102685390  [KO:K04441] [EC:2.7.11.24]
102685434  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
102685435  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102685644  ereg; proepiregulin [KO:K09784]
102685646  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102685764  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X4 [KO:K04428] [EC:2.7.11.25]
102685769  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102685777  [KO:K05462]
102685904  [KO:K22603]
102685958  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102686119  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
102686213  fgf23; fibroblast growth factor 23 [KO:K22428]
102686223  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102686248  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102686322  [KO:K04460] [EC:3.1.3.16]
102686339  [KO:K04358]
102686442  fgf22; fibroblast growth factor 22 [KO:K04358]
102686516  vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
102686641  [KO:K04373] [EC:2.7.11.1]
102686683  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102686735  [KO:K04358]
102686784  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102686848  angpt2; angiopoietin-2 [KO:K05466]
102686890  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102686895  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102686902  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K04372] [EC:2.7.11.1]
102686951  prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102686973  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102687082  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102687228  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102687237  mras; ras-related protein M-Ras [KO:K07831]
102687347  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
102687369  angpt1; angiopoietin-1 isoform X2 [KO:K05465]
102687397  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102687423  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
102687434  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102687483  rapgef2; rap guanine nucleotide exchange factor 2 isoform X11 [KO:K08018]
102687525  [KO:K03283]
102687529  cacng6; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
102687539  relb; transcription factor RelB isoform X1 [KO:K09253]
102687608  dusp9; dual specificity protein phosphatase 9 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102687718  [KO:K03283]
102687732  cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102687735  [KO:K08845] [EC:2.7.11.1]
102687878  mapk10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
102687905  [KO:K04424] [EC:2.7.11.25]
102687984  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102688101  ppm1a; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
102688129  hspb1; heat shock protein beta-1 [KO:K04455]
102688212  fgf4; fibroblast growth factor 4 [KO:K04358]
102688224  fgf5; fibroblast growth factor 5 [KO:K04358]
102688253  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102688366  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102688449  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102688555  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102688566  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102688700  fgf10; fibroblast growth factor 10 [KO:K04358]
102688711  lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
102688713  dusp7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102688714  stmn1; stathmin [KO:K04381]
102688740  [KO:K04455]
102688757  rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
102688783  max; protein max isoform X2 [KO:K04453]
102688795  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102688904  pdgfc; platelet-derived growth factor C isoform X2 [KO:K05450]
102688918  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102689161  [KO:K04448]
102689167  [KO:K04457] [EC:3.1.3.16]
102689284  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102689566  [KO:K22603]
102689601  fgf16; fibroblast growth factor 16 [KO:K04358]
102689722  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
102689749  nrtn; neurturin [KO:K25414]
102689763  fgf3; fibroblast growth factor 3 [KO:K04358]
102689777  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102689834  jund; transcription factor jun-D [KO:K04449]
102689860  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102689881  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102689943  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102689948  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X13 [KO:K04407] [EC:2.7.11.1]
102690009  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
102690045  ikbkb; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102690254  arrb2; beta-arrestin-2 [KO:K04439]
102690285  [KO:K04374]
102690321  fgf7; fibroblast growth factor 7 [KO:K04358]
102690385  rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
102690433  akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102690467  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102690527  [KO:K05453]
102690611  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X3 [KO:K04435]
102690698  [KO:K04466] [EC:2.7.11.25]
102690777  rras2; ras-related protein R-Ras2 [KO:K07830]
102690789  tp53; cellular tumor antigen p53 isoform X3 [KO:K04451]
102690879  fos; proto-oncogene c-Fos [KO:K04379]
102690901  srf; serum response factor isoform X1 [KO:K04378]
102691085  [KO:K04379]
102691138  [KO:K04440] [EC:2.7.11.24]
102691196  [KO:K02187] [EC:3.4.22.56]
102691207  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102691210  [KO:K04373] [EC:2.7.11.1]
102691241  figf; vascular endothelial growth factor D [KO:K05449]
102691261  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102691327  nras; GTPase NRas [KO:K07828]
102691336  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102691453  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102691474  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102691509  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102691524  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102691532  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102691572  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102691719  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102691752  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102691753  map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102691792  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102691836  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102691880  tgfb3; transforming growth factor beta-3 [KO:K13377]
102691940  ntf3; neurotrophin-3 [KO:K04356]
102692006  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102692018  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102692022  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102692092  [KO:K04388] [EC:2.7.11.30]
102692139  [KO:K04348] [EC:3.1.3.16]
102692188  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102692225  [KO:K02583]
102692301  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102692334  fgf2; fibroblast growth factor 2 [KO:K18497]
102692342  map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04426] [EC:2.7.11.25]
102692360  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102692400  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102692535  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102692545  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102692563  rac2; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102692628  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102692639  [KO:K17534] [EC:2.7.11.25]
102692738  ngf; beta-nerve growth factor [KO:K02582]
102692752  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X4 [KO:K04373] [EC:2.7.11.1]
102692769  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
102692817  fgf1; fibroblast growth factor 1 [KO:K18496]
102692821  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102692983  [KO:K03283]
102692997  [KO:K04402]
102693016  [KO:K16859]
102693051  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102693060  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
102693125  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102693197  [KO:K04402]
102693293  pspn; persephin [KO:K25416]
102693329  epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102693388  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102693526  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
102693638  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102693673  [KO:K04402]
102693691  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102693746  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102693762  jun; transcription factor AP-1 [KO:K04448]
102693793  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
102693824  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102693875  fgf9; fibroblast growth factor 9 isoform X2 [KO:K04358]
102693991  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102694148  fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
102694350  dusp5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102694529  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102694627  [KO:K04412]
102694665  arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
102694666  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
102694678  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102694681  [KO:K16342] [EC:3.1.1.4]
102694874  [KO:K04526]
102694945  igf1; insulin-like growth factor I isoform X3 [KO:K05459]
102694964  [KO:K04380]
102695055  gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102695073  [KO:K04526]
102695077  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
102695139  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102695221  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102695292  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
102695548  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X10 [KO:K04462] [EC:2.1.1.367]
102695552  ppm1b; protein phosphatase 1B isoform X3 [KO:K04461] [EC:3.1.3.16]
102695616  crkl; crk-like protein [KO:K04438]
102695690  [KO:K03283]
102695708  flna; filamin-A isoform X7 [KO:K04437]
102695733  [KO:K04441] [EC:2.7.11.24]
102695888  [KO:K03173] [EC:2.3.2.27]
102695902  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102695926  [KO:K04441] [EC:2.7.11.24]
102695953  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102695970  [KO:K04441] [EC:2.7.11.24]
102696038  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102696072  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102696189  kras; GTPase KRas isoform X3 [KO:K07827]
102696260  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102696329  fgf6; fibroblast growth factor 6 [KO:K04358]
102696447  [KO:K05466]
102696469  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102696482  [KO:K04849]
102696491  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102696513  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102696537  insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102696550  mef2c; myocyte-specific enhancer factor 2C isoform X10 [KO:K04454]
102696581  grb2; growth factor receptor-bound protein 2 [KO:K04364]
102696645  [KO:K05449]
102696844  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102696953  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102697033  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
102697036  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102697085  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102697197  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102697231  rap1b; ras-related protein Rap-1b [KO:K07836]
102697398  hras; GTPase HRas [KO:K02833]
102697421  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102697422  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
102697455  stk4; serine/threonine-protein kinase 4 [KO:K04411]
102697641  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X5 [KO:K04862]
102697859  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102697890  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102698007  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102698086  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
102698253  [KO:K04393]
102698319  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102698339  vegfc; vascular endothelial growth factor C [KO:K05449]
102698450  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
102698540  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
102698575  [KO:K05462]
102698609  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102698694  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
102698741  [KO:K04441] [EC:2.7.11.24]
102698772  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102698856  [KO:K04386]
102698936  tgfb1; transforming growth factor beta-1 [KO:K13375]
102698941  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
102698950  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102698976  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102699051  [KO:K04386]
102699065  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102699116  [KO:K16510] [EC:2.7.11.1]
102699199  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X7 [KO:K12326]
107077295  [KO:K08774]
107077336  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
107078012  [KO:K16342] [EC:3.1.1.4]
107078787  [KO:K04466] [EC:2.7.11.25]
107079423  [KO:K04358]
107079892  [KO:K03173] [EC:2.3.2.27]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
loc04070  Phosphatidylinositol signaling system
loc04110  Cell cycle
loc04115  p53 signaling pathway
loc04210  Apoptosis
loc04310  Wnt signaling pathway
KO pathway
ko04010   

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