KEGG   PATHWAY: mcal00600
Entry
mcal00600                   Pathway                                
Name
Sphingolipid metabolism - Mus caroli (Ryukyu mouse)
Class
Metabolism; Lipid metabolism
Pathway map
mcal00600  Sphingolipid metabolism
mcal00600

Module
mcal_M00066  Lactosylceramide biosynthesis [PATH:mcal00600]
mcal_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:mcal00600]
mcal_M00094  Ceramide biosynthesis [PATH:mcal00600]
mcal_M00099  Sphingosine biosynthesis [PATH:mcal00600]
mcal_M00100  Sphingosine degradation [PATH:mcal00600]
Other DBs
GO: 0006665
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110284342  Acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
110284797  B4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
110285283  Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
110285303  Cers6; ceramide synthase 6 isoform X2 [KO:K23727]
110285496  Asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
110285803  B4galt5; beta-1,4-galactosyltransferase 5 isoform X1 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
110286683  Gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
110290058  Sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
110290861  Gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
110291335  Sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
110291396  Ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
110291523  Cers2; ceramide synthase 2 [KO:K24621]
110291657  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
110291886  Kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
110292543  Ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
110292739  Acer2; alkaline ceramidase 2 isoform X2 [KO:K01441] [EC:3.5.1.23]
110292749  Degs1; sphingolipid delta(4)-desaturase DES1 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
110292752  Gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
110292859  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
110294367  Psapl1; proactivator polypeptide-like 1 [KO:K12382]
110297745  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
110297874  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110298134  Acer3; alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
110298856  Neu3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
110299355  Cers3; ceramide synthase 3 isoform X2 [KO:K24622]
110299630  Cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
110299751  Asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
110299943  Cers4; ceramide synthase 4 [KO:K24621]
110300562  Smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
110301320  Hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
110301926  Glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
110302835  Psap; prosaposin isoform X1 [KO:K12382]
110302844  B4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [KO:K00725] [EC:2.4.1.92]
110303128  Sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
110303185  Plpp2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
110303264  Neu2; sialidase-2 isoform X2 [KO:K12357] [EC:3.2.1.18]
110303460  Smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
110304712  Neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
110305516  Gal3st1; galactosylceramide sulfotransferase isoform X2 [KO:K01019] [EC:2.8.2.11]
110305526  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
110305666  Gm2a; ganglioside GM2 activator [KO:K12383]
110306102  Enpp7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
110307036  Galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
110307111  Sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
110307304  Sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
110307385  Degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
110307554  Plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
110307844  Sptlc1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
110307867  Hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
110309691  Samd8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
110310406  Cers5; ceramide synthase 5 isoform X1 [KO:K23727]
110310695  Cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
110310893  Arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
110311500  Smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
110312529  Neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
115031925  [KO:K07553] [EC:2.4.1.274]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
mcal00260  Glycine, serine and threonine metabolism
mcal00601  Glycosphingolipid biosynthesis - lacto and neolacto series
mcal00603  Glycosphingolipid biosynthesis - globo and isoglobo series
mcal00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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