KEGG   PATHWAY: mlk00830
Entry
mlk00830                    Pathway                                
Name
Retinol metabolism - Mustela lutreola (European mink)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
mlk00830  Retinol metabolism
mlk00830

Other DBs
GO: 0006776
Organism
Mustela lutreola (European mink) [GN:mlk]
Gene
131817484  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
131830028  alcohol dehydrogenase E chain isoform X1 [KO:K13951] [EC:1.1.1.1]
131830058  all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
131830078  alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
131819641  LOW QUALITY PROTEIN: alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
131808935  DHRS3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
131836377  dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
131827127  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
131825717  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
131826707  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
131836713  RDH11; retinol dehydrogenase 11 isoform X1 [KO:K11152] [EC:1.1.1.300]
131835372  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
131818379  RDH13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
131838580  RDH16; retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
131826814  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
131838584  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
131831559  LRAT; lecithin retinol acyltransferase isoform X1 [KO:K00678] [EC:2.3.1.135]
131826344  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
131821576  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
131821353  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
131809341  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
131838633  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
131827589  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
131827590  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
131827973  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
131835861  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
131835692  ALDH1A3; retinaldehyde dehydrogenase 3 isoform X1 [KO:K07249] [EC:1.2.1.36]
131813201  ALDH1A1; aldehyde dehydrogenase 1A1 [KO:K07249] [EC:1.2.1.36]
131828645  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
131840286  cytochrome P450 26B1 isoform X1 [KO:K12664] [EC:1.14.14.-]
131828646  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
131835779  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
131835777  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
131818347  cytochrome P450 2A13 [KO:K07411] [EC:1.14.14.1]
131818436  cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
131817740  cytochrome P450 2B11 isoform X1 [KO:K07412] [EC:1.14.14.1]
131817741  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
131828623  cytochrome P450 2C21 isoform X1 [KO:K07413] [EC:1.14.14.1]
131828625  cytochrome P450 2C41-like isoform X1 [KO:K07413] [EC:1.14.14.1]
131817493  cytochrome P450 2S1 isoform X1 [KO:K07420] [EC:1.14.14.1]
131819107  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
131819108  cytochrome P450 3A12 isoform X1 [KO:K07424] [EC:1.14.14.1]
131819109  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
131819112  LOW QUALITY PROTEIN: cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
131819872  cytochrome P450 2W1 isoform X1 [KO:K07423] [EC:1.14.14.-]
131809952  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
131810435  cytochrome P450 4A6-like isoform X1 [KO:K07425] [EC:1.14.14.80]
131810436  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
131810494  cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
131827314  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
131823517  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
131823538  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
131823550  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
131823553  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
131840379  RETSAT; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
131826897  cytochrome P450 27C1 isoform X1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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