KEGG   PATHWAY: mmur04972
Entry
mmur04972                   Pathway                                
Name
Pancreatic secretion - Microcebus murinus (gray mouse lemur)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
mmur04972  Pancreatic secretion
mmur04972

Other DBs
GO: 0030157
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105855233  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105856078  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105856080  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
105856500  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
105856501  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105856969  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
105857276  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105857747  SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951]
105858975  CTRL; chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
105859653  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
105859856  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
105859934  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105860614  RAB27B; ras-related protein Rab-27B [KO:K07886]
105860923  SLC26A3; chloride anion exchanger [KO:K14078]
105861219  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105861402  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105861760  [KO:K05030]
105861766  [KO:K05028]
105861768  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
105861769  [KO:K05027]
105862220  [KO:K01540]
105862666  SCTR; secretin receptor isoform X1 [KO:K04588]
105862683  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
105862687  [KO:K01539] [EC:7.2.2.13]
105863538  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
105863954  [KO:K01176] [EC:3.2.1.1]
105864005  [KO:K01176] [EC:3.2.1.1]
105865371  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105865764  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
105866617  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105866973  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105867325  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105867391  KCNQ1; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
105867497  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105867514  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
105867954  [KO:K07901]
105867991  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
105868094  RAB11A; ras-related protein Rab-11A [KO:K07904]
105868229  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
105868254  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105868281  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105868697  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105869370  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
105869384  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105869763  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
105870050  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
105870064  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
105870160  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105870485  [KO:K01346] [EC:3.4.21.71]
105870668  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105870951  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105872433  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105873275  PRSS2; trypsin-2 isoform X1 [KO:K01312] [EC:3.4.21.4]
105873340  [KO:K01312] [EC:3.4.21.4]
105873632  [KO:K01345] [EC:3.4.21.70]
105873633  [KO:K01345] [EC:3.4.21.70]
105874417  CCK; cholecystokinin [KO:K05226]
105874518  [KO:K04632]
105874520  [KO:K04632]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105874961  RHOA; transforming protein RhoA [KO:K04513]
105875474  [KO:K01310] [EC:3.4.21.1]
105875475  CTRB1; chymotrypsinogen B [KO:K01310] [EC:3.4.21.1]
105876068  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
105876545  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
105876813  PNLIPRP2; pancreatic lipase-related protein 2 [KO:K14075] [EC:3.1.1.3]
105876817  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
105876942  PNLIP; pancreatic triacylglycerol lipase [KO:K14073] [EC:3.1.1.3]
105877507  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
105878468  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105878770  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
105879218  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105879870  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105880040  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105880919  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105880992  RAP1B; ras-related protein Rap-1b [KO:K07836]
105881031  [KO:K04513]
105881162  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
105881239  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
105881240  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
105881918  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
105882651  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105882731  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105883057  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
105883167  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
105883982  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105883984  PLA2G2D; group IID secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
105883985  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
105883986  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105884000  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105884002  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105884349  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105884745  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105884812  CPA2; carboxypeptidase A2 isoform X1 [KO:K01298] [EC:3.4.17.15]
105884873  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
105885566  RAB3D; ras-related protein Rab-3D [KO:K07884]
109730119  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
mmur04020  Calcium signaling pathway
mmur04530  Tight junction
mmur04973  Carbohydrate digestion and absorption
mmur04974  Protein digestion and absorption
mmur04975  Fat digestion and absorption
mmur04977  Vitamin digestion and absorption
KO pathway
ko04972   

DBGET integrated database retrieval system