KEGG   PATHWAY: mmur04020
Entry
mmur04020                   Pathway                                
Name
Calcium signaling pathway - Microcebus murinus (gray mouse lemur)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mmur04020  Calcium signaling pathway
mmur04020

Other DBs
GO: 0019722
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854850  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105855469  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105855971  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
105856032  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105856078  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105856433  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105856500  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
105856501  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105856532  F2R; proteinase-activated receptor 1 [KO:K03914]
105857027  PLN; cardiac phospholamban [KO:K05852]
105857128  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105857150  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105857276  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105857293  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105857364  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X5 [KO:K00476] [EC:1.14.11.16]
105857645  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105857693  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
105857795  FGF10; fibroblast growth factor 10 [KO:K04358]
105857991  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105858210  [KO:K02183]
105858269  [KO:K13755] [EC:3.1.4.17]
105858406  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105858448  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105858450  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105858458  ADRB2; beta-2 adrenergic receptor [KO:K04142]
105858532  [KO:K04856]
105858625  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105858897  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105858914  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105859219  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105859221  RYR3; ryanodine receptor 3 [KO:K04963]
105859260  TNNC2; troponin C, skeletal muscle [KO:K12042]
105859475  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105859583  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105859653  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
105859934  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105859992  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105860184  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105860211  [KO:K05863]
105860312  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
105860421  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
105860786  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105860843  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105860951  GNAL; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
105861219  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105861402  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105861596  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105861802  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
105861810  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
105861813  [KO:K05216]
105861814  [KO:K05216]
105862314  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105862501  FGF1; fibroblast growth factor 1 [KO:K18496]
105862684  CASQ1; calsequestrin-1 [KO:K23468]
105862784  ADORA2A; adenosine receptor A2a [KO:K04266]
105862832  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
105862892  [KO:K06856]
105862930  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
105863147  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
105863245  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105863259  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105863295  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105863534  PTAFR; platelet-activating factor receptor [KO:K04279]
105863798  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
105864337  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
105864380  TPCN1; two pore calcium channel protein 1 [KO:K16896]
105864623  [KO:K10784]
105864671  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
105865027  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105865371  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105865636  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
105865654  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
105865659  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105865679  FGF21; fibroblast growth factor 21 [KO:K22429]
105865738  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
105865757  FLT4; vascular endothelial growth factor receptor 3 isoform X6 [KO:K05097] [EC:2.7.10.1]
105865764  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
105865830  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105866077  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
105866079  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105866146  FGF16; fibroblast growth factor 16 [KO:K04358]
105866168  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
105866169  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
105866328  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105866614  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
105866617  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105866622  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105866801  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
105866961  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
105867016  CALM2; calmodulin [KO:K02183]
105867172  FGF18; fibroblast growth factor 18 [KO:K04358]
105867325  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105867366  TACR1; substance-P receptor [KO:K04222]
105867398  FGF19; fibroblast growth factor 19 [KO:K22603]
105867400  FGF3; fibroblast growth factor 3 [KO:K04358]
105867413  FGF4; fibroblast growth factor 4 [KO:K04358]
105867514  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
105867837  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105867839  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105867915  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105868229  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
105868281  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105868349  ORAI2; protein orai-2 isoform X1 [KO:K16057]
105868355  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105868697  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105868699  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
105868798  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105868864  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105868976  OXTR; oxytocin receptor [KO:K04229]
105869034  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
105869309  AVPR1B; vasopressin V1b receptor [KO:K04227]
105869368  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105869384  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105869569  CALM3; calmodulin [KO:K02183]
105869591  SLC8A2; sodium/calcium exchanger 2 isoform X2 [KO:K05849]
105869756  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
105869973  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105870055  [KO:K02183]
105870127  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105870162  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105870211  TACR2; substance-K receptor isoform X1 [KO:K04223]
105870274  MRLN; myoregulin [KO:K22643]
105870388  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
105870403  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105870668  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105870727  FGF7; fibroblast growth factor 7 [KO:K04358]
105870804  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105870811  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105871018  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
105871056  ORAI3; protein orai-3 [KO:K16058]
105871065  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
105871274  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105871313  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105871902  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105871992  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
105872099  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105872262  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105872305  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105872349  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105872433  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
105872480  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
105873105  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105873434  CALML4; calmodulin-like protein 4 [KO:K02183]
105873493  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105873750  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105873751  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105873955  TBXA2R; LOW QUALITY PROTEIN: thromboxane A2 receptor [KO:K04264]
105873965  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
105873966  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105873977  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105874518  [KO:K04632]
105874520  [KO:K04632]
105874557  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105874668  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105874971  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
105874982  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
105875049  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105875072  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105875389  ADRB1; beta-1 adrenergic receptor [KO:K04141]
105875691  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
105875726  NTSR1; neurotensin receptor type 1 [KO:K04211]
105875864  TFEB; transcription factor EB [KO:K15590]
105875869  VEGFA; vascular endothelial growth factor A [KO:K05448]
105876154  SLN; sarcolipin [KO:K22642]
105876207  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
105876221  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
105876291  CALM1; calmodulin [KO:K02183]
105876685  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105876758  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
105877018  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
105877123  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
105877126  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105877681  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105877770  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
105878143  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105878206  [KO:K23449]
105878222  [KO:K23449]
105878468  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105878471  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105878570  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105878704  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105878875  FGF9; fibroblast growth factor 9 [KO:K04358]
105878912  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105878946  SMIM6; small integral membrane protein 6 [KO:K26468]
105878971  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105879007  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105879034  TACR3; neuromedin-K receptor [KO:K04224]
105879047  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
105879218  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
105879219  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
105879227  P2RX5; P2X purinoceptor 5 [KO:K05219]
105879346  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105879489  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
105879502  [KO:K04360] [EC:2.7.10.1]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105879866  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105880040  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
105880277  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
105880475  HRH2; histamine H2 receptor [KO:K04150]
105880477  DRD1; D(1A) dopamine receptor [KO:K04144]
105880567  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
105880911  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
105880915  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
105880917  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
105880919  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105880957  AVPR1A; vasopressin V1a receptor [KO:K04226]
105881238  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105881454  FGF6; fibroblast growth factor 6 [KO:K04358]
105881457  FGF23; fibroblast growth factor 23 [KO:K22428]
105881767  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105881838  EDNRA; endothelin-1 receptor [KO:K04197]
105882072  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
105882194  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
105882219  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
105882232  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105882375  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
105882404  GRPR; gastrin-releasing peptide receptor [KO:K04169]
105882414  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
105882495  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105882525  FGF20; fibroblast growth factor 20 [KO:K04358]
105882598  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105882651  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105882657  HRH1; histamine H1 receptor [KO:K04149]
105882731  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105882821  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
105882970  EDNRB; endothelin B receptor [KO:K04198]
105883000  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
105883149  [KO:K06856]
105883168  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105883215  HTR5A; 5-hydroxytryptamine receptor 5A isoform X2 [KO:K04161]
105883254  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
105883291  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
105883457  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
105883579  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
105883785  [KO:K04360] [EC:2.7.10.1]
105883822  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105883845  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
105884011  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105884236  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105884349  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105884538  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
105884701  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
105884723  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105884745  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105884926  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105885120  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105885431  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105885634  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
105885735  [KO:K04515] [EC:2.7.11.17]
105885801  BDKRB2; B2 bradykinin receptor [KO:K03916]
105885802  BDKRB1; B1 bradykinin receptor [KO:K03915]
105885820  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
109730003  C24H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mmur04010  MAPK signaling pathway
mmur04070  Phosphatidylinositol signaling system
mmur04210  Apoptosis
mmur04720  Long-term potentiation
mmur04730  Long-term depression
KO pathway
ko04020   

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