KEGG   PATHWAY: mpuf04350
Entry
mpuf04350                   Pathway                                
Name
TGF-beta signaling pathway - Mustela putorius furo (domestic ferret)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpuf04350  TGF-beta signaling pathway
mpuf04350

Other DBs
GO: 0007179
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101670047  BMP4; bone morphogenetic protein 4 [KO:K04662]
101670127  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
101671040  GREM2; gremlin-2 isoform X1 [KO:K23318]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101671091  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101671650  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101671894  SKI; ski oncogene [KO:K26503]
101672693  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
101672732  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
101672818  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101672835  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101673045  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
101673051  RBL1; retinoblastoma-like protein 1 [KO:K04681]
101673136  GDF6; growth/differentiation factor 6 [KO:K20012]
101673576  AMH; muellerian-inhibiting factor [KO:K04665]
101674533  INHBB; inhibin beta B chain [KO:K22687]
101674698  BMP6; bone morphogenetic protein 6 [KO:K16620]
101674742  TFR2; transferrin receptor protein 2 [KO:K23910]
101675099  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101675432  FST; follistatin isoform X1 [KO:K04661]
101675518  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101675764  [KO:K14736]
101675928  NEO1; neogenin [KO:K06766]
101676444  [KO:K14736]
101676762  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
101676768  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
101676870  TGIF2; homeobox protein TGIF2 [KO:K19553]
101676902  HFE; hereditary hemochromatosis protein isoform X2 [KO:K26535]
101677162  LRRC32; leucine-rich repeat-containing protein 32 isoform X1 [KO:K26316]
101677182  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101677354  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101677371  BMP2; bone morphogenetic protein 2 [KO:K21283]
101677398  NCOR1; nuclear receptor corepressor 1 isoform X14 [KO:K04650]
101677916  NRROS; negative regulator of reactive oxygen species isoform X2 [KO:K26317]
101677980  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101678400  TGFB3; transforming growth factor beta-3 [KO:K13377]
101678407  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
101678475  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
101678479  SMAD6; mothers against decapentaplegic homolog 6 isoform X1 [KO:K04677]
101678637  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
101678837  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
101678848  FBN1; fibrillin-1 [KO:K06825]
101679041  RGMB; RGM domain family member B [KO:K06847]
101679429  NOG; noggin [KO:K04658]
101679624  EMP3; epithelial membrane protein 3 [KO:K26257]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101679847  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
101679858  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101679891  RHOA; transforming protein RhoA [KO:K04513]
101680095  INHBA; inhibin beta A chain [KO:K04667]
101680784  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
101680913  [KO:K19558]
101680954  HDAC2; histone deacetylase 2 isoform X2 [KO:K06067] [EC:3.5.1.98]
101681029  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
101681230  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101681953  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101682425  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
101682800  ACVR2B; activin receptor type-2B isoform X2 [KO:K13596] [EC:2.7.11.30]
101682864  INHBE; inhibin beta E chain [KO:K22689]
101682866  GREM1; gremlin-1 [KO:K23318]
101682868  [KO:K03094]
101683016  HAMP; hepcidin [KO:K23106]
101683021  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101683129  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
101683245  INHBC; inhibin beta C chain [KO:K22688]
101683615  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101683625  GDF7; growth/differentiation factor 7 [KO:K20013]
101683638  DCN; decorin [KO:K04660]
101683686  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
101683910  CHRD; chordin [KO:K04657]
101684109  CUL1; cullin-1 [KO:K03347]
101684580  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
101685213  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
101685224  BMP7; bone morphogenetic protein 7 [KO:K16621]
101685652  TGIF1; homeobox protein TGIF1 [KO:K19383]
101685798  IGSF1; immunoglobulin superfamily member 1 [KO:K26168]
101686117  [KO:K04668]
101686321  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
101686467  FMOD; fibromodulin [KO:K08121]
101686721  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101686724  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101686835  SP1; transcription factor Sp1 [KO:K04684]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101687227  [KO:K03347]
101687381  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
101687674  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101689115  RGMA; repulsive guidance molecule A isoform X2 [KO:K23096]
101689142  HFE2; hemojuvelin [KO:K23100]
101689271  E2F5; transcription factor E2F5 [KO:K04682]
101689754  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101689895  SMAD7; mothers against decapentaplegic homolog 7 [KO:K19631]
101689981  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
101690221  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
101690225  NODAL; nodal homolog [KO:K04666]
101691050  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
101691122  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101691860  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101692389  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
101692491  GDF5; growth/differentiation factor 5 [KO:K04664]
101692671  E2F4; transcription factor E2F4 [KO:K04682]
101692723  SKIL; ski-like protein isoform X1 [KO:K18499]
101692860  BMP8B; bone morphogenetic protein 8B [KO:K16622]
101693413  BMP8A; bone morphogenetic protein 8A [KO:K16622]
101693549  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X4 [KO:K04678] [EC:2.3.2.26]
101693741  IFNG; interferon gamma [KO:K04687]
101694197  THBS1; thrombospondin-1 [KO:K16857]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
mpuf04010  MAPK signaling pathway
mpuf04110  Cell cycle
mpuf04120  Ubiquitin mediated proteolysis
mpuf04210  Apoptosis
KO pathway
ko04350   

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