KEGG   PATHWAY: mpuf04010
Entry
mpuf04010                   Pathway                                
Name
MAPK signaling pathway - Mustela putorius furo (domestic ferret)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpuf04010  MAPK signaling pathway
mpuf04010

Other DBs
GO: 0000165
Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101669870  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101669888  RRAS; ras-related protein R-Ras [KO:K07829]
101669926  [KO:K03283]
101670127  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
101670246  [KO:K03283]
101670390  [KO:K04424] [EC:2.7.11.25]
101670448  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101670524  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101670543  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101670597  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101670606  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101670612  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101670774  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101671091  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101671103  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101671137  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
101671170  RELB; transcription factor RelB isoform X1 [KO:K09253]
101671328  VEGFC; vascular endothelial growth factor C [KO:K05449]
101671349  FGF19; fibroblast growth factor 19 [KO:K22603]
101671536  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101671648  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101671736  FGF20; fibroblast growth factor 20 [KO:K04358]
101671799  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
101671970  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101672035  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101672072  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101672160  FIGF; vascular endothelial growth factor D [KO:K05449]
101672254  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
101672433  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101672634  FGF18; fibroblast growth factor 18 [KO:K04358]
101672723  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101672764  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101672795  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101672956  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101673044  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101673065  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101673094  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [KO:K04849]
101673170  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101673290  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
101673439  AREG; amphiregulin [KO:K09782]
101673707  HSPB1; heat shock protein beta-1 [KO:K04455]
101673776  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101673813  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101673903  EREG; proepiregulin [KO:K09784]
101673953  FGF16; fibroblast growth factor 16 [KO:K04358]
101673997  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101674061  FLT4; vascular endothelial growth factor receptor 3 isoform X8 [KO:K05097] [EC:2.7.10.1]
101674139  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101674211  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101674245  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101674490  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101674633  SRF; serum response factor [KO:K04378]
101674676  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101674882  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
101675014  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101675046  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
101675211  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101675380  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101675438  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101675450  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101675530  FGF4; fibroblast growth factor 4 [KO:K04358]
101675655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101675757  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101675790  STK3; serine/threonine-protein kinase 3 [KO:K04412]
101675837  FGF3; fibroblast growth factor 3 [KO:K04358]
101675854  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675945  VEGFA; vascular endothelial growth factor A [KO:K05448]
101675984  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675997  FGF9; fibroblast growth factor 9 [KO:K04358]
101676119  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X3 [KO:K04463] [EC:2.7.12.2]
101676159  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101676197  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
101676286  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101676293  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
101676370  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101676423  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101676547  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101676559  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101676562  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101676758  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101676775  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101676827  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101676883  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
101676890  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101676895  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101676957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101677072  INSR; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
101677145  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
101677182  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101677333  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101677426  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101677543  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101677577  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101677610  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101677715  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
101677794  TP53; cellular tumor antigen p53 [KO:K04451]
101677976  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101678147  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101678164  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101678248  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101678280  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101678301  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101678308  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101678400  TGFB3; transforming growth factor beta-3 [KO:K13377]
101678429  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101678451  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101678500  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101678743  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101678749  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
101678870  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101678913  CRKL; crk-like protein [KO:K04438]
101678949  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101679339  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101679746  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X10 [KO:K04850]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101679776  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101679834  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101679855  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101679858  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101679947  MAPT; microtubule-associated protein tau isoform X2 [KO:K04380]
101680034  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101680042  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101680239  RELA; transcription factor p65 [KO:K04735]
101680348  JUN; transcription factor AP-1 [KO:K04448]
101680372  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101680416  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101680524  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101680542  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101680578  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101680658  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101680871  FGF5; fibroblast growth factor 5 [KO:K04358]
101680922  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101681080  FGF10; fibroblast growth factor 10 [KO:K04358]
101681317  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101681333  KRAS; GTPase KRas isoform X3 [KO:K07827]
101681349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681593  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101681641  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101681756  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101681860  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101681935  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101681986  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101682116  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101682209  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101682258  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101682419  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101682439  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101682511  MAX; protein max isoform X1 [KO:K04453]
101682550  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101682554  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101682563  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101682830  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [KO:K04406] [EC:2.7.11.1]
101682927  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101682942  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101682951  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101683038  NRAS; GTPase NRas [KO:K07828]
101683091  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
101683168  FGF6; fibroblast growth factor 6 [KO:K04358]
101683223  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101683248  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101683363  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101683475  FGF23; fibroblast growth factor 23 [KO:K22428]
101683554  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101683736  CRK; adapter molecule crk isoform X1 [KO:K04438]
101683753  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
101684002  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101684009  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101684105  DAXX; death domain-associated protein 6 isoform X3 [KO:K02308]
101684232  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101684239  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101684361  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101684374  STMN1; stathmin [KO:K04381]
101684479  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101684534  MECOM; MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
101684587  RAP1A; ras-related protein Rap-1A [KO:K04353]
101684763  NTF4; neurotrophin-4 [KO:K12457]
101684783  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101684873  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101684880  NRTN; neurturin [KO:K25414]
101684904  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101684928  INS; insulin [KO:K04526]
101685038  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101685125  JUND; transcription factor jun-D [KO:K04449]
101685236  FOS; proto-oncogene c-Fos [KO:K04379]
101685370  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101685422  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101685475  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
101685539  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101685574  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101685599  [KO:K17534] [EC:2.7.11.25]
101685779  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101685824  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101686122  MRAS; ras-related protein M-Ras [KO:K07831]
101686186  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
101686271  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101686350  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101686362  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X3 [KO:K04408] [EC:2.7.11.1]
101686402  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101686414  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101686674  ARRB2; beta-arrestin-2 [KO:K04439]
101686850  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
101686911  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
101686932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101686957  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101686980  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101687038  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
101687115  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101687195  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101687324  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101687419  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
101687517  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101687666  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
101687739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101687799  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101687880  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101688006  IL1B; interleukin-1 beta [KO:K04519]
101688180  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101688256  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101688258  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101688261  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101688319  ARTN; artemin [KO:K25415]
101688348  PSPN; persephin [KO:K25416]
101688390  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101688476  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101688552  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101688760  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101688771  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101688786  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
101688800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101689101  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2 [KO:K04405]
101689134  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101689137  EFNA3; ephrin-A3 [KO:K05462]
101689165  PGF; placenta growth factor isoform X1 [KO:K16859]
101689191  KITLG; kit ligand isoform X1 [KO:K05461]
101689297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101689415  EFNA4; ephrin-A4 [KO:K05462]
101689510  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101689515  FLNA; filamin-A isoform X1 [KO:K04437]
101689561  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101689712  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101689754  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101689811  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
101689861  FGF1; fibroblast growth factor 1 [KO:K18496]
101689879  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
101690038  TGFA; protransforming growth factor alpha [KO:K08774]
101690295  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
101690408  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101690456  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101690484  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101690521  NF1; neurofibromin [KO:K08052]
101690544  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101690549  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
101690814  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101690825  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101690858  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101690986  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101691149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101691212  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
101691230  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101691242  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101691404  RAP1B; ras-related protein Rap-1b [KO:K07836]
101691506  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101691659  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
101691743  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101691850  IL1A; interleukin-1 alpha [KO:K04383]
101692143  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692386  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101692433  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101692436  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101692458  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101692465  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101692508  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101692938  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101693248  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101693424  FGF21; fibroblast growth factor 21 [KO:K22429]
101693507  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101693585  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101693629  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101693661  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101693694  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101693911  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101693913  FGF8; fibroblast growth factor 8 [KO:K04358]
101694005  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101694006  NGF; beta-nerve growth factor [KO:K02582]
101694107  [KO:K16342] [EC:3.1.1.4]
101694124  [KO:K04374]
101694276  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
106004293  EFNA1; ephrin-A1 [KO:K05462]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mpuf04070  Phosphatidylinositol signaling system
mpuf04110  Cell cycle
mpuf04115  p53 signaling pathway
mpuf04210  Apoptosis
mpuf04310  Wnt signaling pathway
mpuf04668  TNF signaling pathway
KO pathway
ko04010   

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