KEGG   PATHWAY: myd04141
Entry
myd04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Myotis davidii (David's myotis)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
myd04141  Protein processing in endoplasmic reticulum
myd04141

Other DBs
GO: 0030433 0034976
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102755050  SEC61A2; Sec61 translocon alpha 2 subunit [KO:K10956]
102770957  SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
102768801  SEC61B; Sec61 translocon beta subunit [KO:K09481]
102763022  SEC61G; Sec61 translocon gamma subunit [KO:K07342]
102768630  SEC62; SEC62 homolog, preprotein translocation factor [KO:K12275]
102752819  SEC63; SEC63 homolog, protein translocation regulator [KO:K09540]
102768909  RPN1; ribophorin I [KO:K12666]
102771825  RPN2; ribophorin II [KO:K12667]
102771317  DAD1; defender against cell death 1 [KO:K12668]
102765003  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [KO:K12670]
102765077  STT3A; STT3A, catalytic subunit of the oligosaccharyltransferase complex [KO:K07151] [EC:2.4.99.18]
102753759  STT3B; STT3B, catalytic subunit of the oligosaccharyltransferase complex [KO:K07151] [EC:2.4.99.18]
102769356  MAGT1; magnesium transporter 1 [KO:K19478]
102770218  TUSC3; tumor suppressor candidate 3 [KO:K19478]
102766509  OSTC; oligosaccharyltransferase complex non-catalytic subunit [KO:K26501]
102762397  TMEM258; transmembrane protein 258 [KO:K26502]
102775421  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
102772601  CKAP4; cytoskeleton associated protein 4 [KO:K13999]
102760019  RRBP1; ribosome binding protein 1 [KO:K14000]
102758126  SIL1; SIL1 nucleotide exchange factor [KO:K14001]
102756456  HYOU1; hypoxia up-regulated 1 [KO:K09486]
102764844  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
102772047  DNAJB11; DnaJ heat shock protein family (Hsp40) member B11 [KO:K09517]
102751699  DNAJC1; DnaJ heat shock protein family (Hsp40) member C1 [KO:K09521]
102767637  DNAJC3; DnaJ heat shock protein family (Hsp40) member C3 [KO:K09523]
102771807  DNAJC10; DnaJ heat shock protein family (Hsp40) member C10 [KO:K09530] [EC:1.8.4.-]
102751824  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
102764765  GANAB; glucosidase II alpha subunit [KO:K05546] [EC:3.2.1.207]
102762171  PRKCSH; protein kinase C substrate 80K-H [KO:K08288]
102769852  CANX; calnexin [KO:K08054]
102775509  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
102752004  CALR; calreticulin [KO:K08057]
102764904  MAN1A1; mannosidase alpha class 1A member 1 [KO:K01230] [EC:3.2.1.113]
102763868  MAN1C1; mannosidase alpha class 1C member 1 [KO:K01230] [EC:3.2.1.113]
102766164  MAN1A2; mannosidase alpha class 1A member 2 [KO:K01230] [EC:3.2.1.113]
102775495  MAN1B1; mannosidase alpha class 1B member 1 [KO:K23741] [EC:3.2.1.209]
102758920  LMAN2; lectin, mannose binding 2 [KO:K10082]
102775438  LMAN1; lectin, mannose binding 1 [KO:K10080]
102766571  LMAN1L; lectin, mannose binding 1 like [KO:K10081]
102753887  PREB; prolactin regulatory element binding [KO:K14003]
102755215  SAR1B; secretion associated Ras related GTPase 1B [KO:K07953] [EC:3.6.5.-]
102768433  SAR1A; secretion associated Ras related GTPase 1A [KO:K07953] [EC:3.6.5.-]
102766228  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102758883  SEC31B; SEC31 homolog B, COPII coat complex component [KO:K14005]
102774844  SEC31A; SEC31 homolog A, COPII coat complex component [KO:K14005]
102765754  SEC23B; Sec23 homolog B, coat complex II component [KO:K14006]
102765470  SEC23A; Sec23 homolog A, coat complex II component [KO:K14006]
102754941  SEC24A; SEC24 homolog A, COPII coat complex component [KO:K14007]
102769610  SEC24D; SEC24 homolog D, COPII coat complex component [KO:K14007]
102771912  SEC24C; SEC24 homolog C, COPII coat complex component [KO:K14007]
102754081  SEC24B; SEC24 homolog B, COPII coat complex component [KO:K14007]
102767355  UGGT2; UDP-glucose glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
102769938  UGGT1; UDP-glucose glycoprotein glucosyltransferase 1 [KO:K11718] [EC:2.4.1.-]
102754733  EDEM1; ER degradation enhancing alpha-mannosidase like protein 1 [KO:K10084]
102762548  EDEM2; ER degradation enhancing alpha-mannosidase like protein 2 [KO:K10085]
102753346  EDEM3; ER degradation enhancing alpha-mannosidase like protein 3 [KO:K10086]
102758585  P4HB; prolyl 4-hydroxylase subunit beta [KO:K09580] [EC:5.3.4.1]
102751774  PDIA4; protein disulfide isomerase family A member 4 [KO:K09582] [EC:5.3.4.1]
102768821  PDIA6; protein disulfide isomerase family A member 6 [KO:K09584] [EC:5.3.4.1]
102758196  ERP29; endoplasmic reticulum protein 29 [KO:K09586]
102756380  TXNDC5; thioredoxin domain containing 5 [KO:K13984] [EC:5.3.4.1]
102751279  ERO1A; endoplasmic reticulum oxidoreductase 1 alpha [KO:K10950] [EC:1.8.4.-]
102764352  ERO1B; endoplasmic reticulum oxidoreductase 1 beta [KO:K10976] [EC:1.8.4.-]
102759264  OS9; OS9, endoplasmic reticulum lectin [KO:K10088]
102752454  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
102768160  SSR1; signal sequence receptor subunit 1 [KO:K13249]
102768586  SSR2; signal sequence receptor subunit 2 [KO:K13250]
102757459  SSR3; signal sequence receptor subunit 3 [KO:K13251]
102767117  SSR4; signal sequence receptor subunit 4 [KO:K04571]
102762269  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
102771160  TRAM1; translocation associated membrane protein 1 [KO:K14010]
102759314  DERL1; derlin 1 [KO:K11519]
102754839  DERL2; derlin 2 [KO:K13989]
102770197  DERL3; derlin 3 [KO:K13989]
102762083  UBXN4; UBX domain protein 4 [KO:K24348]
102752884  UBXN1; UBX domain protein 1 [KO:K24348]
102761042  UBXN2A; UBX domain protein 2A [KO:K24349]
102762009  UBXN6; UBX domain protein 6 [KO:K14011]
102772205  UBXN8; UBX domain protein 8 [KO:K24351]
102761276  NSFL1C; NSFL1 cofactor [KO:K14012]
102770935  VCP; valosin containing protein [KO:K13525]
102756607  NPLOC4; NPL4 homolog, ubiquitin recognition factor [KO:K14015]
102755860  UFD1L; ubiquitin fusion degradation 1 like (yeast) [KO:K14016]
102774775  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102772438  heat shock cognate 71 kDa protein-like [KO:K03283]
102764580  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
102764862  heat shock 70 kDa protein 1-like [KO:K03283]
102759639  DNAJA1; DnaJ heat shock protein family (Hsp40) member A1 [KO:K09502]
102774685  DNAJA2; DnaJ heat shock protein family (Hsp40) member A2 [KO:K09503]
102774990  DNAJB1; DnaJ heat shock protein family (Hsp40) member B1 [KO:K09507]
102766528  DNAJB2; DnaJ heat shock protein family (Hsp40) member B2 [KO:K09508]
102773233  DNAJB12; DnaJ heat shock protein family (Hsp40) member B12 [KO:K09518]
102766939  DNAJC5G; DnaJ heat shock protein family (Hsp40) member C5 gamma [KO:K09525]
102761227  DNAJC5B; DnaJ heat shock protein family (Hsp40) member C5 beta [KO:K09525]
102755484  DNAJC5; DnaJ heat shock protein family (Hsp40) member C5 [KO:K09525]
102773782  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102759595  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102770956  HSPA4L; heat shock protein family A (Hsp70) member 4 like [KO:K09485]
102771635  HSPH1; heat shock protein family H (Hsp110) member 1 [KO:K09485]
102759078  BAG1; BCL2 associated athanogene 1 [KO:K09555]
102756536  BAG2; BCL2 associated athanogene 2 [KO:K09556]
102761057  HSPBP1; HSPA (Hsp70) binding protein 1 [KO:K09562]
102771958  CRYAA; crystallin alpha A [KO:K09541]
102766063  CRYAB; crystallin alpha B [KO:K09542]
102773294  YOD1; YOD1 deubiquitinase [KO:K13719] [EC:3.1.2.-]
102775462  PLAA; phospholipase A2 activating protein [KO:K14018]
102753705  RAD23B; RAD23 homolog B, nucleotide excision repair protein [KO:K10839]
102752287  RAD23A; RAD23 homolog A, nucleotide excision repair protein [KO:K10839]
102765628  UBQLN3; ubiquilin 3 [KO:K04523]
102768880  UBQLN4; ubiquilin 4 [KO:K04523]
102774148  UBQLN2; ubiquilin 2 [KO:K04523]
102754410  UBQLN1; ubiquilin 1 [KO:K04523]
102763723  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
102752216  ATXN3; ataxin 3 [KO:K11863] [EC:3.4.22.-]
102771647  UBE4B; ubiquitination factor E4B [KO:K10597] [EC:2.3.2.27]
102767480  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102757699  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
102763654  ATF4; activating transcription factor 4 [KO:K04374]
102760852  PPP1R15A; protein phosphatase 1 regulatory subunit 15A [KO:K14019]
102764039  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102769473  BCL2; BCL2, apoptosis regulator [KO:K02161]
102755559  ATF6; activating transcription factor 6 [KO:K09054]
102767346  ATF6B; activating transcription factor 6 beta [KO:K09049]
102774692  WFS1; wolframin ER transmembrane glycoprotein [KO:K14020]
102773346  MBTPS1; membrane bound transcription factor peptidase, site 1 [KO:K08653] [EC:3.4.21.112]
102759985  MBTPS2; membrane bound transcription factor peptidase, site 2 [KO:K07765] [EC:3.4.24.85]
102767486  XBP1; X-box binding protein 1 [KO:K09027]
102773882  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102772361  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102771311  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102760954  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102772062  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102764416  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102775351  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102761803  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102764949  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102770312  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
102769788  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102773959  caspase-12-like [KO:K04741] [EC:3.4.22.-]
102772800  MARCH6; membrane associated ring-CH-type finger 6 [KO:K10661] [EC:2.3.2.27]
102767943  UBE2J1; ubiquitin conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
102761527  UBE2J2; ubiquitin conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
102758914  UBE2G1; ubiquitin conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
102759738  UBE2G2; ubiquitin conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
102773565  SYVN1; synoviolin 1 [KO:K10601] [EC:2.3.2.27]
102768669  RNF5; ring finger protein 5 [KO:K10666] [EC:2.3.2.27]
102752945  RNF185; ring finger protein 185 [KO:K10666] [EC:2.3.2.27]
102768176  SELENOS; selenoprotein S [KO:K14025]
102765673  SEL1L; SEL1L ERAD E3 ligase adaptor subunit [KO:K14026]
102758345  SEL1L2; SEL1L2 ERAD E3 ligase adaptor subunit [KO:K14026]
102765053  HERPUD1; homocysteine inducible ER protein with ubiquitin like domain 1 [KO:K14027]
102768348  AMFR; autocrine motility factor receptor [KO:K10636] [EC:2.3.2.36]
102774689  STUB1; STIP1 homology and U-box containing protein 1 [KO:K09561] [EC:2.3.2.27]
102753715  UBE2D2; ubiquitin conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
102769929  UBE2D3; ubiquitin conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
102774993  UBE2D4; ubiquitin conjugating enzyme E2 D4 (putative) [KO:K06689] [EC:2.3.2.23]
102775019  UBE2D1; ubiquitin conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
102775089  ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
102757960  PARK2; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
102760790  RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
102771406  CUL1; cullin 1 [KO:K03347]
102756513  SKP1; S-phase kinase associated protein 1 [KO:K03094]
102764371  FBXO2; F-box protein 2 [KO:K10099]
102765136  FBXO6; F-box protein 6 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
myd00510  N-Glycan biosynthesis
myd03050  Proteasome
myd03060  Protein export
myd04210  Apoptosis
myd04930  Type II diabetes mellitus
myd05010  Alzheimer disease
myd05012  Parkinson disease
myd05020  Prion disease
KO pathway
ko04141   
LinkDB

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