KEGG   PATHWAY: nni04150
Entry
nni04150                    Pathway                                
Name
mTOR signaling pathway - Nipponia nippon (crested ibis)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
nni04150  mTOR signaling pathway
nni04150

Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104008506  [KO:K02151]
104008620  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104008622  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104008666  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
104008684  RHOA; transforming protein RhoA [KO:K04513]
104008826  SGK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
104008958  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104008980  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104008993  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104009342  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104009591  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
104009660  [KO:K00408]
104010067  WNT6; protein Wnt-6 [KO:K00445]
104010099  WNT10A; protein Wnt-10a [KO:K01357]
104010198  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
104010259  FZD7; frizzled-7 [KO:K02432]
104010262  FZD5; frizzled-5 [KO:K02375]
104010320  WNT2B; protein Wnt-2b [KO:K00182]
104010364  NRAS; GTPase NRas [KO:K07828]
104010412  [KO:K04526]
104010592  GATSL3; GATS-like protein 3 [KO:K23080]
104010898  CAB39L; calcium-binding protein 39-like [KO:K08272]
104011200  WNT4; protein Wnt-4 [KO:K00408]
104011272  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104011447  DEPDC5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
104011478  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
104011840  WNT16; protein Wnt-16 [KO:K01558]
104011874  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
104012008  FNIP1; folliculin-interacting protein 1 [KO:K20400]
104012172  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104012215  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
104012261  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
104012385  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104012421  GATSL2; GATS-like protein 2 [KO:K23081]
104012473  FZD9; frizzled-9 [KO:K02842]
104012655  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
104012662  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104012670  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
104012697  KRAS; GTPase KRas isoform X1 [KO:K07827]
104012807  MIOS; WD repeat-containing protein mio [KO:K20407]
104012837  [KO:K01384]
104012855  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104013011  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104013018  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
104013358  IGF1; insulin-like growth factor I [KO:K05459]
104013446  WNT8B; protein Wnt-8b [KO:K00714]
104013521  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104013560  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
104013623  WNT2; protein Wnt-2 [KO:K00182]
104013732  SLC38A9; LOW QUALITY PROTEIN: putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
104013818  [KO:K07198] [EC:2.7.11.31]
104014051  FZD1; frizzled-1 [KO:K02432]
104014273  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
104014361  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104014444  [KO:K02145] [EC:7.1.2.2]
104014534  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104014703  FZD3; frizzled-3 [KO:K02329]
104014790  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
104014902  RHEB; GTP-binding protein Rheb [KO:K07208]
104015115  FLCN; folliculin [KO:K09594]
104015144  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104015160  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104015269  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104015276  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104015319  WNT5A; protein Wnt-5a [KO:K00444]
104015409  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104015632  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104015640  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
104015763  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104016011  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104016028  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104016060  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104016188  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104016253  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104016450  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104016496  IRS1; insulin receptor substrate 1 [KO:K16172]
104016523  FZD6; frizzled-6 [KO:K02376]
104016535  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104017015  SEC13; LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
104017047  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104017228  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104017299  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
104017304  HRAS; GTPase HRas [KO:K02833]
104017358  FZD4; frizzled-4 [KO:K02354]
104017398  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104017402  WNT9B; protein Wnt-9b [KO:K01064]
104017501  WDR59; WD repeat-containing protein 59 [KO:K20409]
104017683  SEH1L; nucleoporin SEH1 [KO:K14299]
104017701  SESN2; sestrin-2 [KO:K20394]
104017717  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104017807  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104017932  RPS6; 40S ribosomal protein S6 [KO:K02991]
104017995  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
104018007  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104018306  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104018434  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
104018452  WNT8A; protein Wnt-8a [KO:K00714]
104018639  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
104018715  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
104018719  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104018809  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104018902  FZD2; frizzled-2 [KO:K02235]
104018990  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
104019224  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
104019443  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
104019491  SOS2; son of sevenless homolog 2 [KO:K03099]
104019574  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
104019595  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104019760  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104019783  FZD10; frizzled-10 [KO:K02842]
104019864  [KO:K07198] [EC:2.7.11.31]
104019896  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104020042  [KO:K20402]
104020099  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104020205  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
104020249  WNT5B; protein Wnt-5b [KO:K00444]
104020263  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104020298  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104020665  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104020924  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
104020934  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104020958  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
104021086  RRAGB; ras-related GTP-binding protein B [KO:K16185]
104021192  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104021248  FNIP2; folliculin-interacting protein 2 [KO:K20401]
104021328  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104021728  WNT9A; protein Wnt-9a [KO:K01064]
104021729  WNT3A; protein Wnt-3a [KO:K00312]
104021818  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
104021860  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
104021946  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104022133  SOS1; son of sevenless homolog 1 [KO:K03099]
104022169  WNT7A; protein Wnt-7a [KO:K00572]
104022513  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104022540  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104022726  WNT11; protein Wnt-11 [KO:K01384]
104022929  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104023182  TSC1; hamartin isoform X1 [KO:K07206]
104023231  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
104023431  NPRL3; nitrogen permease regulator 3-like protein [KO:K20406]
104023477  WDR24; WD repeat-containing protein 24 [KO:K20408]
104023651  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104023668  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104023672  CAB39; calcium-binding protein 39 [KO:K08272]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
nni00561  Glycerolipid metabolism
nni04010  MAPK signaling pathway
nni04140  Autophagy - animal
nni04810  Regulation of actin cytoskeleton
nni04910  Insulin signaling pathway
KO pathway
ko04150   

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