KEGG   PATHWAY: nni04010
Entry
nni04010                    Pathway                                
Name
MAPK signaling pathway - Nipponia nippon (crested ibis)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nni04010  MAPK signaling pathway
nni04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nipponia nippon (crested ibis) [GN:nni]
Gene
104008570  SRF; serum response factor [KO:K04378]
104008622  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104008716  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104008738  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104008753  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
104008816  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104008848  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104009116  [KO:K04851]
104009239  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104009262  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
104009322  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
104009380  ANGPT2; angiopoietin-2 [KO:K05466]
104009422  BDNF; brain-derived neurotrophic factor [KO:K04355]
104009490  FGF3; fibroblast growth factor 3 [KO:K04358]
104009491  FGF4; fibroblast growth factor 4 [KO:K04358]
104009492  FGF19; fibroblast growth factor 19 [KO:K22603]
104009631  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
104009659  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
104009680  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104009888  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104009891  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104010005  [KO:K04424] [EC:2.7.11.25]
104010014  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104010094  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104010315  RAP1A; LOW QUALITY PROTEIN: ras-related protein Rap-1A [KO:K04353]
104010337  NGF; beta-nerve growth factor [KO:K02582]
104010338  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104010364  NRAS; GTPase NRas [KO:K07828]
104010400  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104010403  IGF2; insulin-like growth factor II [KO:K13769]
104010412  [KO:K04526]
104010425  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104010500  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104010621  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104010637  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104010702  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104010750  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104010752  HGF; hepatocyte growth factor [KO:K05460]
104010753  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104010773  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104010775  [KO:K04436]
104010825  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104010969  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104010994  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104011007  RAP1B; ras-related protein Rap-1b [KO:K07836]
104011070  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104011073  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104011199  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104011234  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104011272  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104011301  PLA2G4A; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104011434  CRKL; crk-like protein [KO:K04438]
104011468  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
104011638  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104011693  KITLG; kit ligand [KO:K05461]
104011761  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104011817  [KO:K04460] [EC:3.1.3.16]
104011928  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104011958  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104011991  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
104012024  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104012242  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104012255  MAPT; microtubule-associated protein tau [KO:K04380]
104012329  [KO:K05462]
104012362  CACNB4; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
104012385  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104012443  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104012487  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
104012608  EFNA5; ephrin-A5 [KO:K05462]
104012652  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104012697  KRAS; GTPase KRas isoform X1 [KO:K07827]
104012855  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104013128  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
104013194  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104013235  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104013238  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104013320  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
104013358  IGF1; insulin-like growth factor I [KO:K05459]
104013554  FGF8; fibroblast growth factor 8 [KO:K04358]
104013588  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104013612  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104013668  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104013777  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104013813  [KO:K04360] [EC:2.7.10.1]
104013874  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104013882  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104013978  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104014191  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104014195  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104014196  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104014296  CACNG5; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104014297  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104014320  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104014353  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104014361  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104014362  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104014494  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
104014534  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104014564  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104015011  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
104015059  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104015109  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104015149  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
104015206  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104015218  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104015248  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104015276  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104015320  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104015344  [KO:K17534] [EC:2.7.11.25]
104015402  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104015431  ARTN; artemin [KO:K25415]
104015433  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104015461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104015670  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104015788  [KO:K05467]
104015868  FGF5; fibroblast growth factor 5 [KO:K04358]
104015877  EREG; proepiregulin [KO:K09784]
104015878  AREG; amphiregulin [KO:K09782]
104015904  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104016008  CRK; adapter molecule crk [KO:K04438]
104016019  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
104016028  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104016039  FGF17; fibroblast growth factor 17 [KO:K04358]
104016227  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104016296  EFNA2; ephrin-A2 [KO:K05462]
104016313  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
104016373  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104016391  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
104016433  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
104016458  ANGPT1; angiopoietin-1 [KO:K05465]
104016462  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104016558  FGF18; fibroblast growth factor 18 [KO:K04358]
104016627  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104016870  MYC; myc proto-oncogene protein [KO:K04377]
104016915  NF1; neurofibromin [KO:K08052]
104017026  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104017044  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104017047  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104017125  FGF7; fibroblast growth factor 7 [KO:K04358]
104017228  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104017304  HRAS; GTPase HRas [KO:K02833]
104017527  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
104017546  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
104017593  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104017717  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104017723  STMN1; stathmin [KO:K04381]
104017829  MAP3K6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
104017979  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104018007  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104018093  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104018369  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104018429  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104018435  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104018444  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104018674  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
104018695  VEGFA; vascular endothelial growth factor A [KO:K05448]
104018719  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104018763  [KO:K25414]
104018809  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104018900  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104018925  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104018968  DUSP1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104018970  MRAS; ras-related protein M-Ras [KO:K07831]
104018989  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104018994  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104019102  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
104019181  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
104019336  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104019339  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104019340  [KO:K04386]
104019491  SOS2; son of sevenless homolog 2 [KO:K03099]
104019551  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104019559  [KO:K04437]
104019573  [KO:K03175] [EC:2.3.2.27]
104019650  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104019653  TGFB2; transforming growth factor beta-2 [KO:K13376]
104019694  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
104019815  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104019884  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
104019998  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104020099  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104020209  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104020241  [KO:K04388] [EC:2.7.11.30]
104020248  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104020263  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104020321  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104020345  [KO:K16342] [EC:3.1.1.4]
104020346  [KO:K16342] [EC:3.1.1.4]
104020347  [KO:K16342] [EC:3.1.1.4]
104020440  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104020441  [KO:K16342] [EC:3.1.1.4]
104020443  [KO:K16342] [EC:3.1.1.4]
104020445  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104020460  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104020507  EFNA3; ephrin-A3 [KO:K05462]
104020565  [KO:K04453]
104020574  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104020665  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104020687  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104020776  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104020818  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104020821  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104020832  FGF20; fibroblast growth factor 20 [KO:K04358]
104020921  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
104020954  [KO:K05866] [EC:3.1.3.48]
104020998  TGFB3; transforming growth factor beta-3 [KO:K13377]
104021035  PGF; placenta growth factor [KO:K16859]
104021082  [KO:K05096] [EC:2.7.10.1]
104021157  EGF; pro-epidermal growth factor [KO:K04357]
104021184  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104021249  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
104021276  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
104021286  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104021326  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104021328  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104021344  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104021357  PDGFC; platelet-derived growth factor C [KO:K05450]
104021538  [KO:K04453]
104021577  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
104021590  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104021619  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104021621  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104021625  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104021643  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104021698  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104021753  [KO:K04421] [EC:2.7.11.25]
104021766  NTF3; neurotrophin-3 [KO:K04356]
104021773  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
104021846  FGF23; fibroblast growth factor 23 [KO:K22428]
104021856  FGF6; fibroblast growth factor 6 [KO:K04358]
104021869  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104021875  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104021941  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104022029  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104022125  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104022133  SOS1; son of sevenless homolog 1 [KO:K03099]
104022144  CD14; monocyte differentiation antigen CD14 [KO:K04391]
104022209  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
104022234  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104022250  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104022374  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104022513  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104022532  FIGF; vascular endothelial growth factor D [KO:K05449]
104022599  [KO:K04519]
104022736  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104022751  ARRB1; beta-arrestin-1 [KO:K04439]
104022826  [KO:K04460] [EC:3.1.3.16]
104022929  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104022998  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104023019  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104023035  FGF9; fibroblast growth factor 9 [KO:K04358]
104023065  PDGFD; platelet-derived growth factor D [KO:K05450]
104023083  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104023360  RELB; transcription factor RelB [KO:K09253]
104023557  FGF16; fibroblast growth factor 16 [KO:K04358]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
nni04070  Phosphatidylinositol signaling system
nni04110  Cell cycle
nni04115  p53 signaling pathway
nni04210  Apoptosis
nni04310  Wnt signaling pathway
KO pathway
ko04010   

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