KEGG   PATHWAY: nss04115
Entry
nss04115                    Pathway                                
Name
p53 signaling pathway - Notechis scutatus (mainland tiger snake)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
nss04115  p53 signaling pathway
nss04115

Organism
Notechis scutatus (mainland tiger snake) [GN:nss]
Gene
113410120  THBS1; thrombospondin-1 [KO:K16857]
113410159  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
113410218  CD82; CD82 antigen [KO:K06509]
113410261  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113410680  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
113411095  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
113411211  [KO:K10136]
113411212  [KO:K10136]
113411533  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
113411538  SESN1; sestrin-1 isoform X1 [KO:K10141]
113411860  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113412263  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113412454  [KO:K08738]
113412521  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
113412558  [KO:K04722]
113413142  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
113413669  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
113413884  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
113414346  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
113415045  [KO:K06621]
113415422  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
113415983  [KO:K08738]
113416315  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113416395  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
113416426  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
113417133  SERPINB5; serpin B5 [KO:K10139]
113417136  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113417288  SESN3; sestrin-3 [KO:K10141]
113417344  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
113417495  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
113417529  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
113417597  SFN; 14-3-3 protein sigma [KO:K06644]
113417858  CCNG2; cyclin-G2 [KO:K10146]
113418126  MDM4; protein Mdm4 isoform X1 [KO:K10127]
113418146  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
113418439  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113418550  BAX; apoptosis regulator BAX [KO:K02159]
113418615  [KO:K02159]
113418663  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
113418767  [KO:K06625]
113418990  [KO:K06625]
113419351  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113419392  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
113419729  [KO:K06625]
113420238  [KO:K10128]
113420258  [KO:K10128]
113420563  SHISA5; protein shisa-5 [KO:K10135]
113420992  [KO:K04722]
113421049  IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
113421661  [KO:K10145]
113421668  [KO:K10145]
113422575  TSC2; tuberin [KO:K07207]
113423067  [KO:K10141]
113423796  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113423945  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
113423982  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
113424449  [KO:K06509]
113424879  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113425161  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113425228  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
113426481  PPP1R13L; relA-associated inhibitor [KO:K27356]
113427161  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
113427162  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
113427663  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
113427879  [KO:K04451]
113428197  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
113428226  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
113428776  TP73; tumor protein p73 [KO:K10148]
113430247  SESN2; sestrin-2 [KO:K20394]
113430869  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113431457  BCL2L1; bcl-2-like protein 1 [KO:K04570]
113431849  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113432811  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
nss04110  Cell cycle
nss04210  Apoptosis
nss04218  Cellular senescence
KO pathway
ko04115   

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