KEGG   PATHWAY: afz04152
Entry
afz04152                    Pathway                                
Name
AMPK signaling pathway - Antechinus flavipes (yellow-footed antechinus)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
afz04152  AMPK signaling pathway
afz04152

Other DBs
GO: 2000479
Organism
Antechinus flavipes (yellow-footed antechinus) [GN:afz]
Gene
127562007  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
127545102  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
127555195  calcium-binding protein 39-like isoform X1 [KO:K08272]
127563139  calcium-binding protein 39 [KO:K08272]
127560426  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
127553224  STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
127564674  leptin [KO:K05424]
127561669  leptin receptor [KO:K05062]
127545450  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
127547328  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
127558613  adiponectin [KO:K07296]
127562707  adiponectin receptor protein 1 [KO:K07297]
127538949  adiponectin receptor protein 2 [KO:K07297]
127563258  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
127556825  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127545541  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
127559188  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
127564149  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
127538054  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127553096  5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
127543201  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
127562618  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
127539100  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
127544019  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
127548047  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
127561719  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
127561726  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
127562454  ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
127537829  ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
127538403  ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
127548868  hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
127558014  LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
127560091  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
127560332  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
127548953  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
127551073  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
127559878  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
127553178  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
127538146  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
127544947  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
127559872  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
127539809  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
127540403  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
127539046  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
127539643  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
127545281  ELAV-like protein 1 isoform X1 [KO:K13088]
127539835  G1/S-specific cyclin-D1 [KO:K04503]
127541195  cyclin-A2 [KO:K06627]
127555246  cyclin-A1 isoform X1 [KO:K06627]
127564557  eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
127544955  elongation factor 2 [KO:K03234]
127555224  forkhead box protein O1 [KO:K07201]
127562063  forkhead box protein O3 [KO:K09408]
127552112  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
127560904  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
127564537  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
127556548  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
127556374  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
127558817  3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
127562168  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
127560599  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
127559918  acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127539913  stearoyl-CoA desaturase 5 isoform X1 [KO:K00507] [EC:1.14.19.1]
127545590  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127548679  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
127540255  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
127538809  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
127556546  carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
127544035  cell death activator CIDE-A isoform X1 [KO:K25893]
127549824  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127539590  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127539655  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
127556425  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
127554975  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
127550069  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
127552220  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
127547333  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127540860  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
127549749  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
127553699  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
127554225  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
127562576  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
127549612  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
127549900  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
127540094  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
127561763  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
127540820  TBC1 domain family member 1 isoform X1 [KO:K18341]
127542571  ras-related protein Rab-2A-like [KO:K07877]
127543830  ras-related protein Rab-2A [KO:K07877]
127545044  ras-related protein Rab-8A [KO:K07901]
127548774  ras-related protein Rab-10 [KO:K07903]
127545302  ras-related protein Rab-11B [KO:K07905]
127550535  ras-related protein Rab-14 [KO:K07881]
127538624  cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
127564273  platelet glycoprotein 4 [KO:K06259]
127537871  insulin-like growth factor I isoform X1 [KO:K05459]
127551347  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
127540738  insulin [KO:K04526]
127545340  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
127553038  insulin receptor substrate 1 [KO:K16172]
127542628  insulin receptor substrate 4 [KO:K07187]
127553464  insulin receptor substrate 2 [KO:K07187]
127555896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127552891  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
127554245  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
127563398  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
127558297  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127545225  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127563028  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
127542756  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
127549861  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127556193  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127559596  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127543419  tuberin isoform X1 [KO:K07207]
127550929  hamartin isoform X1 [KO:K07206]
127539348  GTP-binding protein Rheb [KO:K07208]
127555875  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
127560656  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
127556600  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
127541288  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
127559954  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
127548228  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
127552073  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
127545363  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
afz00010  Glycolysis / Gluconeogenesis
afz00061  Fatty acid biosynthesis
afz00500  Starch and sucrose metabolism
afz01040  Biosynthesis of unsaturated fatty acids
afz04110  Cell cycle
afz04140  Autophagy - animal
afz04150  mTOR signaling pathway
afz04151  PI3K-Akt signaling pathway
afz04910  Insulin signaling pathway
afz04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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