KEGG   PATHWAY: alim04514
Entry
alim04514                   Pathway                                
Name
Cell adhesion molecules - Austrofundulus limnaeus (annual killifish)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
alim04514  Cell adhesion molecules
alim04514

Other DBs
GO: 0050839
Organism
Austrofundulus limnaeus (annual killifish) [GN:alim]
Gene
106526250  uncharacterized protein LOC106526250 [KO:K06449]
106515588  platelet receptor Gi24 [KO:K23268]
106514062  immunoglobulin superfamily member 11-like [KO:K06791]
106519554  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
106521483  uncharacterized protein LOC106521483 [KO:K05412]
106514544  butyrophilin subfamily 2 member A1-like [KO:K06745]
106510835  uncharacterized protein LOC106510835 [KO:K06470]
106525864  T-lymphocyte activation antigen CD80-like isoform X1 [KO:K06710]
106522071  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
106522078  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
106511878  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
106512063  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
106521019  T-cell surface glycoprotein CD4-like [KO:K06454]
106528694  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106528695  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106519573  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
106523581  uncharacterized protein LOC106523581 [KO:K06459]
106528455  CD276 antigen-like [KO:K06746]
106530906  V-set domain-containing T-cell activation inhibitor 1-like [KO:K06747]
106531985  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
106520361  CD166 antigen homolog A-like [KO:K06547]
106534552  CD166 antigen homolog [KO:K06547]
106529381  T-cell differentiation antigen CD6-like isoform X1 [KO:K06456]
106513493  cd226; CD226 antigen isoform X1 [KO:K06567]
106519562  poliovirus receptor homolog [KO:K06531]
106521035  poliovirus receptor-like isoform X1 [KO:K06531]
106529162  nectin-2-like [KO:K06531]
106526910  integrin alpha-M-like [KO:K05718]
106530485  integrin beta-2-like isoform X1 [KO:K06464]
106530048  B-cell receptor CD22-like [KO:K06467]
106530049  sialic acid-binding Ig-like lectin 11 [KO:K06467]
106516795  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
106531353  nectin-3-like protein isoform X1 [KO:K06592]
106529741  nectin-3-like protein [KO:K06592]
106512409  claudin-34-like [KO:K06087]
106531436  claudin-34-like [KO:K06087]
106519179  claudin-10-like [KO:K06087]
106513634  cldn5; claudin-5 [KO:K06087]
106510780  claudin-23-like [KO:K06087]
106510789  claudin-7-B-like [KO:K06087]
106530404  claudin-1-like [KO:K06087]
106529779  claudin-4-like [KO:K06087]
106516360  claudin-15-like isoform X1 [KO:K06087]
106526596  claudin-7-A [KO:K06087]
106522370  claudin-23-like [KO:K06087]
106531180  claudin-15-like [KO:K06087]
106532223  claudin-11-like [KO:K06087]
106533334  cldn15; claudin-15 [KO:K06087]
106514654  claudin-14-like [KO:K06087]
106527409  cldn19; claudin-19 isoform X1 [KO:K06087]
106512421  putative claudin-24 [KO:K06087]
106519714  claudin-14-like [KO:K06087]
106521714  putative claudin-24 [KO:K06087]
106519110  cldn20; claudin-20 [KO:K06087]
106511156  claudin-4-like [KO:K06087]
106520560  claudin-17-like [KO:K06087]
106520561  claudin-8-like [KO:K06087]
106520563  claudin-8-like [KO:K06087]
106533053  claudin-4-like [KO:K06087]
106533055  claudin-4-like [KO:K06087]
106533056  claudin-4-like [KO:K06087]
106533057  claudin-like protein ZF-A89 [KO:K06087]
106533058  claudin-4-like [KO:K06087]
106533059  claudin-4-like [KO:K06087]
106533060  claudin-4-like [KO:K06087]
106533061  claudin-4-like [KO:K06087]
106533062  claudin-4-like [KO:K06087]
106533064  claudin-3-like [KO:K06087]
106526646  claudin-4-like [KO:K06087]
106536119  claudin-1-like [KO:K06087]
106523449  claudin-4-like [KO:K06087]
106523450  claudin-4-like [KO:K06087]
106523479  claudin-4-like [KO:K06087]
106523482  claudin-3-like [KO:K06087]
106523483  claudin-3-like [KO:K06087]
106523484  claudin-4-like [KO:K06087]
106523485  claudin-4-like [KO:K06087]
106523486  claudin-4-like [KO:K06087]
106523487  claudin-like protein ZF-A89 [KO:K06087]
106523488  claudin-like protein ZF-A89 [KO:K06087]
106523489  claudin-like protein ZF-A89 [KO:K06087]
106523490  claudin-4-like [KO:K06087]
106529531  claudin-4-like [KO:K06087]
106533765  claudin-11-like [KO:K06087]
106526094  claudin-5-like [KO:K06087]
106511598  claudin-7-like [KO:K06087]
106528174  claudin-10-like [KO:K06087]
106528182  claudin-10-like [KO:K06087]
106528183  claudin-10-like isoform X1 [KO:K06087]
106530779  claudin-20-like [KO:K06087]
106511520  cldn12; claudin-12 isoform X1 [KO:K06087]
106533054  claudin-4-like [KO:K06087]
106536663  occludin-like [KO:K06088]
106525961  LOW QUALITY PROTEIN: occludin-like [KO:K06088]
106531758  occludin-like [KO:K06088]
106516804  occludin-like [KO:K06088]
106516355  junctional adhesion molecule A-like [KO:K06089]
106524660  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
106511470  junctional adhesion molecule B-like [KO:K06735]
106519823  junctional adhesion molecule B-like [KO:K06735]
106531037  junctional adhesion molecule C-like [KO:K06785]
106520376  jam3; junctional adhesion molecule C [KO:K06785]
106520371  esam; endothelial cell-selective adhesion molecule [KO:K06787]
106536348  endothelial cell-selective adhesion molecule-like [KO:K06787]
106532015  endothelial cell-selective adhesion molecule-like [KO:K06787]
106523980  cadherin-5-like isoform X1 [KO:K06533]
106535264  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
106516500  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
106535616  CD99 antigen-like isoform X1 [KO:K06520]
106530683  CD99 antigen-like protein 2 [KO:K06520]
106521365  integrin alpha-M-like [KO:K06461]
106521369  integrin alpha-M-like [KO:K06461]
106513909  E-selectin-like [KO:K06496]
106521066  itgb1; integrin beta-1 isoform X1 [KO:K05719]
106522907  integrin beta-1-like [KO:K05719]
106515452  itga9; integrin alpha-9 [KO:K06585]
106525062  vcam1; vascular cell adhesion protein 1 [KO:K06527]
106525097  B-cell receptor CD22-like [KO:K06527]
106518320  cd34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
106529865  Golgi apparatus protein 1-like isoform X1 [KO:K06816]
106527441  Golgi apparatus protein 1-like [KO:K06816]
106514077  nectin-1-like [KO:K06081]
106532679  nectin-1-like [KO:K06081]
106533183  nectin-1-like [KO:K06081]
106537394  nectin-1-like [KO:K06081]
106532277  cadherin-2-like [KO:K06736]
106534064  cadherin-2-like [KO:K06736]
106517290  cadherin-2-like isoform X1 [KO:K06736]
106514608  neural cell adhesion molecule 1-like isoform X1 [KO:K06491]
106520379  ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
106514202  neural cell adhesion molecule 1-like isoform X1 [KO:K06491]
106523918  ncam2; neural cell adhesion molecule 2 [KO:K06491]
106525056  l1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
106535229  neural cell adhesion molecule L1.1-like [KO:K06550]
106531143  neural cell adhesion molecule L1-like [KO:K06550]
106514611  cell adhesion molecule 1-like isoform X1 [KO:K06781]
106520385  cell adhesion molecule 1-like isoform X1 [KO:K06781]
106511192  negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
106526408  ntng1; netrin-G1 [KO:K07522]
106516897  netrin-G1-like isoform X1 [KO:K07522]
106515636  lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
106519104  leucine-rich repeat-containing protein 4C-like [KO:K07523]
106536550  uncharacterized protein PB18E9.04c-like isoform X1 [KO:K16359]
106536551  netrin-G2-like [KO:K16359]
106516289  netrin-G2-like [KO:K16359]
106520333  leucine-rich repeat-containing protein 4-like [KO:K16351]
106514766  leucine-rich repeat-containing protein 4-like [KO:K16351]
106516884  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
106517314  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
106517418  leucine-rich repeat-containing protein 4B-like [KO:K16360]
106524802  lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]
106527893  syndecan-2-B-like [KO:K16336]
106536717  syndecan-2-B-like [KO:K16336]
106515755  sdc3; syndecan-3 [KO:K16337]
106530818  syndecan-4-like [KO:K16338]
106525498  integrin alpha-V-like [KO:K06487]
106535612  itgb8; integrin beta-8 isoform X1 [KO:K06591]
106529471  itga8; integrin alpha-8 [KO:K06584]
106516126  nrxn1; neurexin-1-beta isoform X1 [KO:K07377]
106516618  neurexin-1a-like [KO:K07377]
106519990  nrxn3; LOW QUALITY PROTEIN: neurexin 3 [KO:K07377]
106536676  neurexin-1a-like [KO:K07377]
106525132  neurexin-3b-like [KO:K07377]
106531725  neuroligin-4, X-linked-like [KO:K07378]
106533888  nlgn4x; neuroligin-4, X-linked [KO:K07378]
106535946  neuroligin-4, X-linked-like [KO:K07378]
106515968  neuroligin-3-like isoform X1 [KO:K07378]
106517284  nlgn1; neuroligin-1 isoform X1 [KO:K07378]
106516389  neuroligin-3-like isoform X1 [KO:K07378]
106526586  nlgn2; neuroligin-2 isoform X1 [KO:K07378]
106531350  neuroligin-2-like isoform X1 [KO:K07378]
106535774  receptor-type tyrosine-protein phosphatase delta-like isoform X1 [KO:K06778] [EC:3.1.3.48]
106519212  receptor-type tyrosine-protein phosphatase S-like [KO:K06778] [EC:3.1.3.48]
106519809  slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]
106531724  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
106527432  slitrk4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
106523380  slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
106524734  SLIT and NTRK-like protein 5 [KO:K25836]
106523381  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
106514844  ptprd; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
106532527  receptor-type tyrosine-protein phosphatase delta-like isoform X1 [KO:K06777] [EC:3.1.3.48]
106511121  slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]
106518485  SLIT and NTRK-like protein 3 [KO:K25834]
106520795  cadm3; cell adhesion molecule 3 isoform X1 [KO:K06780]
106525481  neuronal cell adhesion molecule-like [KO:K06756]
106523527  neuronal cell adhesion molecule-like isoform X1 [KO:K06756]
106525480  contactin-1a-like [KO:K06759]
106523528  cntn1; contactin-1 isoform X1 [KO:K06759]
106535809  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
106516911  ptprm; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
106536598  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
106534469  contactin-2-like [KO:K06760]
106530076  nfasc; neurofascin [KO:K06757]
106519304  neurofascin-like [KO:K06757]
106528255  cntnap1; contactin-associated protein 1 [KO:K07379]
106525976  contactin-associated protein-like 2 [KO:K07380]
106520799  mpz; myelin protein P0 isoform X1 [KO:K06770]
106533409  mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
106513699  cadherin-1-like [KO:K05689]
106513149  B-cadherin-like [KO:K05689]
106517510  versican core protein-like [KO:K06793]
106526147  integrin alpha-6-like isoform X1 [KO:K06485]
106512651  integrin alpha-6-like [KO:K06485]
106525190  cadherin-4-like isoform X1 [KO:K06797]
106533223  cadherin-4-like [KO:K06797]
106513918  cadherin-15-like [KO:K06809]
106512988  neo1; neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
alim04520  Adherens junction
alim04530  Tight junction
KO pathway
ko04514   
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