KEGG   PATHWAY: bfo04142
Entry
bfo04142                    Pathway                                
Name
Lysosome - Branchiostoma floridae (Florida lancelet)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bfo04142  Lysosome
bfo04142

Other DBs
GO: 0005764
Organism
Branchiostoma floridae (Florida lancelet) [GN:bfo]
Gene
118403173  V-type proton ATPase 116 kDa subunit a1-like isoform X1 [KO:K02154]
118418021  V-type proton ATPase subunit d [KO:K02146]
118418373  V-type proton ATPase subunit d-like [KO:K02146]
118404080  V-type proton ATPase subunit H-like [KO:K02144]
118416075  V-type proton ATPase subunit S1-like isoform X1 [KO:K03662]
118418835  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
118412176  V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]
118410636  dmX-like protein 2 [KO:K24155]
118410793  WD repeat-containing protein 7-like isoform X1 [KO:K24738]
118417927  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
118418097  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
118404562  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
118414050  dipeptidyl peptidase 1-like isoform X1 [KO:K01275] [EC:3.4.14.1]
118404660  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
118405126  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
118414060  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
118407207  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
118410421  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
118411258  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
118415775  cathepsin L-like [KO:K01373] [EC:3.4.22.41]
118418160  cysteine proteinase 1-like [KO:K01373] [EC:3.4.22.41]
118410484  LOW QUALITY PROTEIN: pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
118406160  digestive cysteine proteinase 1-like [KO:K01365] [EC:3.4.22.15]
118406260  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422182  oryzain alpha chain-like [KO:K01365] [EC:3.4.22.15]
118422401  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422574  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422575  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422576  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422580  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422581  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118422582  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118419487  cathepsin O-like isoform X1 [KO:K01374] [EC:3.4.22.42]
118417697  cathepsin Z-like isoform X1 [KO:K08568] [EC:3.4.18.1]
118406889  legumain-like [KO:K01369] [EC:3.4.22.34]
118424708  legumain-like [KO:K01369] [EC:3.4.22.34]
118428919  tripeptidyl-peptidase 1-like isoform X1 [KO:K01279] [EC:3.4.14.9]
118423853  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
118427978  sucrase-isomaltase, intestinal-like [KO:K12316] [EC:3.2.1.20]
118427981  sucrase-isomaltase, intestinal-like [KO:K12316] [EC:3.2.1.20]
118429186  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
118409516  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
118409517  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
118412356  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
118419659  alpha-N-acetylgalactosaminidase-like isoform X1 [KO:K01204] [EC:3.2.1.49]
118431827  alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]
118425041  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
118425146  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
118426722  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
118429136  alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
118408625  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118408702  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118408704  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118408705  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118409321  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118409832  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
118418120  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118420721  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
118411325  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
118411326  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
118412016  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
118411065  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
118419529  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421310  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421322  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421323  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421326  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421327  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421329  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421330  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421333  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
118421335  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421336  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421338  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
118421341  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421700  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
118421704  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118421792  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118427732  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
118429839  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
118430088  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
118430089  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
118430687  hyaluronidase-1-like isoform X1 [KO:K01197] [EC:3.2.1.35]
118421552  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
118411641  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118412106  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
118403590  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118403591  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118404651  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118405951  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118407366  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118407458  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118410571  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118410754  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
118428666  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118428667  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118428764  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
118429766  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118430529  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118430580  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
118422400  arylsulfatase J-like [KO:K01135] [EC:3.1.6.12]
118417061  N-acetylgalactosamine-6-sulfatase-like [KO:K01132] [EC:3.1.6.4]
118426612  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
118419919  iduronate 2-sulfatase-like isoform X1 [KO:K01136] [EC:3.1.6.13]
118428791  N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]
118406886  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
118406888  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
118410931  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
118410933  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
118417415  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
118410922  plancitoxin-1-like [KO:K01158] [EC:3.1.22.1]
118421592  plancitoxin-1-like [KO:K01158] [EC:3.1.22.1]
118414560  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
118407554  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
118420908  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
118405250  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
118424166  sphingomyelin phosphodiesterase-like isoform X1 [KO:K12350] [EC:3.1.4.12]
118424167  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
118420272  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
118419603  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
118421382  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
118410951  prosaposin-like isoform X1 [KO:K12382]
118415794  ganglioside GM2 activator-like [KO:K12383]
118416093  ganglioside GM2 activator-like [KO:K12383]
118406911  uncharacterized protein LOC118406911 [KO:K12383]
118406935  uncharacterized protein LOC118406935 [KO:K12383]
118422061  ganglioside GM2 activator-like [KO:K12383]
118406914  uncharacterized protein LOC118406914 [KO:K12383]
118410583  palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]
118420912  lysosomal thioesterase PPT2-A-like isoform X1 [KO:K01074] [EC:3.1.2.22]
118411121  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118411123  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118411342  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118426854  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118427310  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118411167  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118405364  CD63 antigen-like [KO:K06497]
118406724  CD63 antigen-like [KO:K06497]
118408851  CD63 antigen-like isoform X1 [KO:K06497]
118411204  CD151 antigen-like [KO:K06497]
118412971  lysosome membrane protein 2-like [KO:K12384]
118419955  lysosome membrane protein 2-like isoform X1 [KO:K12384]
118404688  NPC intracellular cholesterol transporter 1-like [KO:K12385]
118409559  NPC intracellular cholesterol transporter 2-like [KO:K13443]
118420542  NPC intracellular cholesterol transporter 2 homolog a-like [KO:K13443]
118431050  NPC intracellular cholesterol transporter 2-like [KO:K13443]
118422688  NPC intracellular cholesterol transporter 2-like [KO:K13443]
118424331  cystinosin-like isoform X1 [KO:K12386]
118403728  sialin-like [KO:K12301]
118404742  sialin-like [KO:K12301]
118404902  sialin-like isoform X1 [KO:K12301]
118404939  sialin-like [KO:K12301]
118406286  sialin-like [KO:K12301]
118406296  sialin-like [KO:K12301]
118407031  sialin-like [KO:K12301]
118407095  sialin-like [KO:K12301]
118407182  sialin-like [KO:K12301]
118407216  sialin-like [KO:K12301]
118410433  sialin-like isoform X1 [KO:K12301]
118417113  sialin-like [KO:K12301]
118419947  sialin-like isoform X1 [KO:K12301]
118419949  sialin-like isoform X1 [KO:K12301]
118419950  sialin-like [KO:K12301]
118419951  sialin-like [KO:K12301]
118420049  sialin-like [KO:K12301]
118403922  metal transporter nramp1 homolog isoform X1 [KO:K21398]
118424398  natural resistance-associated macrophage protein 2-like [KO:K21398]
118409848  lysosomal-associated transmembrane protein 4A-like isoform X1 [KO:K12387]
118420736  ATP-binding cassette sub-family A member 2-like isoform X1 [KO:K05642]
118425257  ATP-binding cassette sub-family B member 9-like isoform X1 [KO:K05656]
118425965  ATP-binding cassette sub-family B member 9-like [KO:K05656]
118426229  ATP-binding cassette sub-family B member 9-like [KO:K05656]
118426613  ATP-binding cassette sub-family B member 9-like [KO:K05656]
118425256  ATP-binding cassette sub-family B member 9-like [KO:K05656]
118422596  uncharacterized protein LOC118422596 isoform X1 [KO:K06546]
118413090  ectonucleoside triphosphate diphosphohydrolase 4-like isoform X1 [KO:K12305] [EC:3.6.1.6]
118416272  sortilin-like [KO:K12388]
118415427  battenin-like [KO:K12389]
118405821  battenin-like [KO:K12389]
118432574  battenin-like isoform X1 [KO:K12389]
118419850  ceroid-lipofuscinosis neuronal protein 5-like [KO:K12390]
118419589  major facilitator superfamily domain-containing protein 8-like isoform X1 [KO:K12307]
118430722  uncharacterized protein LOC118430722 [KO:K12307]
118408382  heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]
118410737  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
118423594  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
118415994  formylglycine-generating enzyme-like [KO:K13444] [EC:1.8.3.7]
118419938  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like [KO:K08239] [EC:2.7.8.17]
118429232  N-acetylglucosamine-1-phosphotransferase subunit gamma-like [KO:K10087]
118418463  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like isoform X1 [KO:K01125] [EC:3.1.4.45]
118418493  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
118429300  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]
118423593  cation-independent mannose-6-phosphate receptor-like isoform X1 [KO:K06564]
118424462  uncharacterized protein LOC118424462 isoform X1 [KO:K10089]
118424907  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
118419374  uncharacterized protein LOC118419374 [KO:K10089]
118421415  uncharacterized protein LOC118421415 isoform X1 [KO:K10089]
118430515  cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
118419625  clathrin light chain B-like isoform X1 [KO:K04645]
118425972  clathrin heavy chain 1 isoform X1 [KO:K04646]
118417323  AP-1 complex subunit gamma-1-like [KO:K12391]
118430441  AP-1 complex subunit beta-1-like isoform X1 [KO:K12392]
118432065  AP-1 complex subunit mu-1 [KO:K12393]
118427838  AP-1 complex subunit sigma-2-like [KO:K12394]
118431367  AP-3 complex subunit delta-1-like isoform X1 [KO:K12396]
118409916  AP-3 complex subunit beta-1-like isoform X1 [KO:K12397]
118420810  AP-3 complex subunit mu-1-like isoform X1 [KO:K12398]
118411499  AP-3 complex subunit sigma-1-like isoform X1 [KO:K12399]
118411613  AP-4 complex subunit epsilon-1-like isoform X1 [KO:K12400]
118418557  AP-4 complex subunit beta-1-like [KO:K12401]
118419633  AP-4 complex subunit mu-1-like [KO:K12402]
118418575  AP-4 complex subunit sigma-like [KO:K12403]
118429154  ADP-ribosylation factor-binding protein GGA2-like isoform X1 [KO:K12404]
118411769  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118412601  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118412606  LITAF domain-containing protein-like [KO:K19363]
118412714  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118408510  lipopolysaccharide-induced tumor necrosis factor-alpha factor-like [KO:K19363]
118409643  LITAF domain-containing protein-like [KO:K19363]
118409644  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118409645  uncharacterized protein LOC118409645 isoform X1 [KO:K19363]
118409899  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118430436  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
118431687  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bfo00511  Other glycan degradation
bfo00531  Glycosaminoglycan degradation
bfo04130  SNARE interactions in vesicular transport
bfo04140  Autophagy - animal
bfo04144  Endocytosis
KO pathway
ko04142   
LinkDB

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