KEGG   PATHWAY: ccrn03013
Entry
ccrn03013                   Pathway                                
Name
Nucleocytoplasmic transport - Chrysoperla carnea
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ccrn03013  Nucleocytoplasmic transport
ccrn03013

Other DBs
GO: 0050658
Organism
Chrysoperla carnea [GN:ccrn]
Gene
123300158  aladin [KO:K14320]
123294043  nucleoporin GLE1 [KO:K18723]
123291654  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
123290895  protein Rae1 [KO:K14298]
123302691  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
123300516  nuclear pore complex protein Nup88 [KO:K14318]
123295170  ran GTPase-activating protein 1 [KO:K14319]
123290665  SUMO-conjugating enzyme UBC9-B [KO:K10577]
123295126  small ubiquitin-related modifier 2 [KO:K12160]
123305095  nuclear pore complex protein Nup160 homolog [KO:K14303]
123295022  nuclear pore complex protein Nup75 [KO:K14304]
123293947  protein SEC13 homolog [KO:K14004]
123305686  nuclear pore complex protein Nup107 [KO:K14301]
123294265  nuclear pore complex protein Nup133 [KO:K14300]
123297585  nucleoporin SEH1-A [KO:K14299]
123301773  nucleoporin Nup43 [KO:K14305]
123299144  nucleoporin Nup37 [KO:K14302]
123297376  nuclear pore glycoprotein p62 [KO:K14306]
123292116  probable nucleoporin Nup54 [KO:K14308]
123295445  nuclear pore complex protein Nup205 [KO:K14310]
123296146  nucleoporin Nup188 [KO:K14311]
123297851  nuclear pore complex protein Nup154 [KO:K14312]
123301581  nuclear pore complex protein Nup93-like [KO:K14309]
123301169  nucleoporin Nup35 [KO:K14313]
123292117  nucleoporin NDC1 [KO:K14315]
123299655  nuclear pore membrane glycoprotein 210 [KO:K14314]
123298095  Krueppel homolog 2 [KO:K20724]
123299048  nucleoprotein TPR isoform X1 [KO:K09291]
123291615  nuclear pore complex protein Nup50 [KO:K14295]
123296620  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
123292143  importin subunit alpha-5 [KO:K15043]
123290718  importin subunit alpha-3 isoform X1 [KO:K23583]
123290483  importin subunit alpha-7 isoform X1 [KO:K15042]
123299302  importin subunit beta isoform X1 [KO:K14293]
123302330  transportin-1-like isoform X1 [KO:K18752]
123296939  transportin-2 [KO:K18752]
123294474  transportin-3 [KO:K15436]
123295345  importin-4-like [KO:K20221]
123292072  importin-5 [KO:K20222]
123295023  importin-7 isoform X1 [KO:K20223]
123302094  importin-9 [KO:K20224]
123300866  importin-11 [KO:K25201]
123304990  importin-13 [KO:K25202]
123300701  snurportin-1 [KO:K13151]
123295161  exportin-1 [KO:K14290]
123297561  exportin-2 isoform X1 [KO:K18423]
123300964  exportin-4-like [KO:K25203]
123298303  exportin-5 [KO:K14289]
123297461  exportin-6 [KO:K25204]
123297641  exportin-7 isoform X1 [KO:K18460]
123296934  GTP-binding nuclear protein Ran [KO:K07936]
123291898  elongation factor 1-alpha [KO:K03231]
123300658  elongation factor 1-alpha-like [KO:K03231]
123297560  phosphorylated adapter RNA export protein [KO:K14291]
123297478  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
123306139  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
123292023  60S ribosomal export protein NMD3 [KO:K07562]
123305287  RNA-binding protein 8A [KO:K12876]
123292378  protein mago nashi [KO:K12877]
123291826  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
123300645  histone deacetylase complex subunit SAP18 [KO:K14324]
123291619  RNA-binding protein with serine-rich domain 1-B [KO:K14325]
123292097  pinin [KO:K13114]
123296979  THO complex subunit 4 [KO:K12881]
123298559  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
123293406  regulator of nonsense transcripts 2 [KO:K14327]
123294000  nuclear RNA export factor 1-like [KO:K14284]
123293139  nuclear RNA export factor 1-like [KO:K14284]
123296389  NTF2-related export protein isoform X1 [KO:K14285]
123304917  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
123293517  partner of Y14 and mago [KO:K14294]
123297647  THO complex subunit 1 [KO:K12878]
123291524  THO complex subunit 2 [KO:K12879]
123297544  THO complex subunit 5 homolog isoform X1 [KO:K13174]
123296097  THO complex subunit 6 homolog [KO:K13175]
123300233  THO complex subunit 7 homolog [KO:K13176]
123305835  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ccrn03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

DBGET integrated database retrieval system