KEGG   PATHWAY: cfa04512
Entry
cfa04512                    Pathway                                
Name
ECM-receptor interaction - Canis lupus familiaris (dog)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cfa04512  ECM-receptor interaction
cfa04512

Other DBs
GO: 0005201
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
403651  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
403824  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
403826  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
403841  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
403840  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
403466  COL4A5; collagen alpha-5(IV) chain precursor [KO:K06237]
403843  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
403496  COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237]
403842  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
403582  COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238]
610649  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
610614  collagen alpha-4(VI) chain-like isoform X4 [KO:K06238]
100856491  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
403668  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
485659  COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238]
481873  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
607609  COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131]
612430  COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131]
100683420  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102156629  LAMA1; laminin subunit alpha-1 [KO:K05637]
480173  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
442954  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
475034  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 isoform X1 [KO:K06241]
475882  LAMB1; laminin subunit beta-1 [KO:K05636]
476626  LAMB2; laminin subunit beta-2 isoform X5 [KO:K06243]
442953  LAMB3; laminin subunit beta-3 [KO:K06244]
483260  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
480034  LAMC1; laminin subunit gamma-1 [KO:K05635]
442939  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
491290  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
609296  CHAD; chondroadherin [KO:K06248]
483273  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
487486  THBS1; thrombospondin-1 [KO:K16857]
610359  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
484087  THBS2; thrombospondin-2 precursor [KO:K04659]
488930  THBS4; thrombospondin-4 [KO:K04659]
476665  COMP; cartilage oligomeric matrix protein [KO:K04659]
403845  FN1; fibronectin [KO:K05717]
478471  SPP1; osteopontin isoform X2 [KO:K06250]
480621  VTN; vitronectin [KO:K06251]
490335  TNN; tenascin-N isoform X6 [KO:K06252]
490334  TNR; tenascin-R [KO:K06252]
481689  TNC; tenascin precursor [KO:K06252]
100682877  TNXB; tenascin-X isoform X16 [KO:K06252]
487891  NPNT; nephronectin isoform X1 [KO:K06824]
478446  FRAS1; extracellular matrix protein FRAS1 isoform X2 [KO:K23379]
486002  FREM2; FRAS1-related extracellular matrix protein 2 isoform X1 [KO:K23380]
481547  FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380]
100683557  DSPP; LOW QUALITY PROTEIN: dentin sialophosphoprotein [KO:K23573]
399544  VWF; von Willebrand factor precursor [KO:K03900]
609146  IBSP; bone sialoprotein 2 [KO:K06253]
487849  DMP1; dentin matrix acidic phosphoprotein 1 [KO:K23328]
487851  MEPE; matrix extracellular phosphoglycoprotein precursor [KO:K26442]
479574  AGRN; agrin isoform X11 [KO:K06254]
403440  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
489210  ITGA1; integrin alpha-1 [KO:K06480]
489208  ITGA2; integrin alpha-2 [KO:K06481]
403789  ITGA2B; integrin alpha-IIb [KO:K06476]
491074  ITGA3; integrin alpha-3 [KO:K06482]
488429  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
486493  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100856563  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
481097  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
487119  ITGA8; integrin alpha-8 [KO:K06584]
477021  ITGA9; integrin alpha-9 [KO:K06585]
608287  ITGA10; integrin alpha-10 isoform X5 [KO:K06586]
478353  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
488437  ITGAV; integrin alpha-V isoform X5 [KO:K06487]
477956  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
403788  ITGB3; integrin beta-3 precursor [KO:K06493]
483318  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
608977  ITGB5; integrin beta-5 [KO:K06588]
488368  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
477598  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
475253  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
403939  CD44; CD44 antigen precursor [KO:K06256]
482986  SDC1; syndecan-1 isoform X1 [KO:K06257]
485893  SDC4; syndecan-4 [KO:K16338]
488943  SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
488723  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
100855661  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
475931  CD36; platelet glycoprotein 4 [KO:K06259]
403638  GP1BA; platelet glycoprotein Ib alpha chain precursor [KO:K06261]
102155348  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
609630  GP9; platelet glycoprotein IX [KO:K06263]
484303  GP6; platelet glycoprotein VI isoform X1 [KO:K06264]
476623  DAG1; dystroglycan precursor [KO:K06265]
478552  CD47; leukocyte surface antigen CD47 precursor [KO:K06266]
611838  HMMR; hyaluronan mediated motility receptor isoform X2 [KO:K06267]
100855768  LOW QUALITY PROTEIN: hyaluronan mediated motility receptor-like [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
cfa04510  Focal adhesion
KO pathway
ko04512   
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