KEGG   PATHWAY: cge04914
Entry
cge04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Cricetulus griseus (Chinese hamster)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
cge04914  Progesterone-mediated oocyte maturation
cge04914

Other DBs
GO: 0001556
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100757656  Pgr; progesterone receptor isoform X1 [KO:K08556]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771734  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100754361  mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
100764964  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100689104  Mapk14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100759172  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100754042  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100763519  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100689068  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100689072  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100689070  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100764561  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100773811  Adcy2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100770498  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100768998  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100765958  Adcy5; LOW QUALITY PROTEIN: adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
100768368  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100756132  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
113837458  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100751372  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100768997  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100767097  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100761359  Aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
103158539  Cpeb4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
100759655  Cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X2 [KO:K02602]
100761763  Cpeb2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 isoform X9 [KO:K02602]
100770232  Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X3 [KO:K02602]
100755331  Spdya; speedy protein A [KO:K08694]
100756506  speedy protein E4 [KO:K08694]
100757839  speedy protein E4A-like isoform X1 [KO:K08694]
100767340  speedy protein E4A [KO:K08694]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100766716  Cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100759649  Ccna2; cyclin-A2 isoform X2 [KO:K06627]
100769969  Ccna1; cyclin-A1 isoform X2 [KO:K06627]
100756276  Mos; proto-oncogene serine/threonine-protein kinase mos isoform X2 [KO:K04367] [EC:2.7.11.1]
100689397  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100773612  ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100770849  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
100750954  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
100756365  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
100771831  Pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
100770842  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100773656  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100755282  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
100769190  Stk10; serine/threonine-protein kinase 10 isoform X2 [KO:K08837] [EC:2.7.11.1]
100760676  Plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
100767961  Cdc25a; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
100765509  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100773417  Cdc25c; M-phase inducer phosphatase 3 isoform X4 [KO:K05867] [EC:3.1.3.48]
100760716  Ins; insulin [KO:K04526]
100751642  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
100768531  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100775064  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X2 [KO:K13296] [EC:3.1.4.17]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100751432  Araf; serine/threonine-protein kinase A-Raf isoform X5 [KO:K08845] [EC:2.7.11.1]
100771486  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100772514  Bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
100689352  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
100753081  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100761766  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
100762149  Fzr1; fizzy-related protein homolog [KO:K03364]
100770891  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
100774636  Anapc2; anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
100770539  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
100763196  LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
100767504  Anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100766376  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100759495  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100765036  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
100752608  Cdc23; cell division cycle protein 23 homolog isoform X2 [KO:K03355]
100772439  Anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100767345  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
100753813  Cdc26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
100766682  anaphase-promoting complex subunit CDC26-like [KO:K03359]
100770713  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
100752128  anaphase-promoting complex subunit 15 [KO:K25228]
100759455  Anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
100751676  Kif22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
cge04010  MAPK signaling pathway
cge04110  Cell cycle
KO pathway
ko04914   
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