Entry
Name
Spliceosome - Cebus imitator (Panamanian white-faced capuchin)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:
cimi ]
Gene
108290608 DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813 ] [EC:5.6.2.6 ]
108286740 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
108309125 small nuclear ribonucleoprotein Sm D1-like isoform X1 [KO:K11087 ]
108301674 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein E-like [KO:K11097 ]
108283924 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093 ]
108300426 PRPF40A; LOW QUALITY PROTEIN: pre-mRNA-processing factor 40 homolog A [KO:K12821 ]
108316053 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821 ]
108292381 TCERG1; LOW QUALITY PROTEIN: transcription elongation regulator 1 [KO:K12824 ]
108290496 PHF5A; PHD finger-like domain-containing protein 5A isoform X3 [KO:K12834 ]
108311213 U2AF1; splicing factor U2AF 35 kDa subunit isoform X2 [KO:K12836 ]
108286346 U2AF1L4; LOW QUALITY PROTEIN: splicing factor U2AF 26 kDa subunit [KO:K12836 ]
108316649 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
108291296 PUF60; poly(U)-binding-splicing factor PUF60 isoform X6 [KO:K12838 ]
108283373 SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
108284472 calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841 ]
108303405 LOW QUALITY PROTEIN: U6 snRNA-associated Sm-like protein LSm2 [KO:K12621 ]
108284548 LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623 ]
108316478 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
108305615 PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662 ]
108299657 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
108295702 USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847 ]
108310376 SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984 ]
108318324 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852 ]
108289020 LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857 ]
108303792 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
108291804 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
108292110 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
108300687 HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283 ]
108303918 LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283 ]
108297673 CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871 ]
108315267 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
108303899 NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882 ]
108296474 heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
108284908 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
108308159 heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
108315246 heterogeneous nuclear ribonucleoproteins C1/C2-like isoform X1 [KO:K12884 ]
108301132 LOW QUALITY PROTEIN: RNA-binding motif protein, X chromosome-like [KO:K12885 ]
108294436 RNA-binding motif protein, X chromosome-like isoform X1 [KO:K12885 ]
108306028 LOW QUALITY PROTEIN: RNA-binding motif protein, X chromosome-like [KO:K12885 ]
108289192 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
108293079 LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M-like [KO:K12887 ]
108283633 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
108306933 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
108294579 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
108293757 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
108303218 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
108308656 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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