KEGG   PATHWAY: cpea04145
Entry
cpea04145                   Pathway                                
Name
Phagosome - Chaetura pelagica (chimney swift)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cpea04145  Phagosome
cpea04145

Other DBs
GO: 0045335
Organism
Chaetura pelagica (chimney swift) [GN:cpea]
Gene
104395598  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
104393412  STX12; syntaxin-12 [KO:K13813]
104390050  STX7; syntaxin-7 [KO:K08488]
104385255  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104391979  ACTL9; actin-like protein 9 isoform X1 [KO:K05692]
104393236  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104393627  STX18; syntaxin-18 [KO:K08492]
104390690  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
104385235  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104385397  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
104386550  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
104397548  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104385659  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104398020  EEA1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
104395351  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
104390617  TFRC; transferrin receptor protein 1 [KO:K06503]
104398560  LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]
104384980  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104384859  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104390061  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104396608  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104397686  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104393429  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104385816  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104390746  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104392650  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
104394830  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
104385653  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]
104396036  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
104388712  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
104396561  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
104391721  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104396902  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104395369  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104396704  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
104394700  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
104387868  RAB7A; ras-related protein Rab-7a [KO:K07897]
104388614  RAB7B; ras-related protein Rab-7b [KO:K07898]
104384920  RILP; LOW QUALITY PROTEIN: rab-interacting lysosomal protein [KO:K13883]
104389073  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104390275  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
104386368  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
104387386  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104396398  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104397616  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104395057  tubulin alpha-3 chain [KO:K07374]
104390488  tubulin alpha-8 chain [KO:K07374]
104391080  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104387340  tubulin alpha-5 chain [KO:K07374]
104387341  tubulin alpha-5 chain-like [KO:K07374]
104384807  tubulin alpha-8 chain-like [KO:K07374]
104398074  tubulin alpha-1C chain [KO:K07374]
104393433  TUBA8; tubulin alpha-8 chain [KO:K07374]
104393492  tubulin alpha-4 chain-like [KO:K07374]
104394219  tubulin beta-7 chain [KO:K07375]
104389608  TUBB1; tubulin beta-1 chain [KO:K07375]
104385812  tubulin beta chain [KO:K07375]
104391590  tubulin beta chain [KO:K07375]
104396963  TUBB6; tubulin beta-6 chain [KO:K07375]
104398356  tubulin beta-3 chain [KO:K07375]
104389019  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
104388273  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
104387427  PIKFYVE; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104393484  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104386992  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
104391004  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
104391006  MPO; LOW QUALITY PROTEIN: myeloperoxidase [KO:K10789] [EC:1.11.2.2]
104397270  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
104393047  LOW QUALITY PROTEIN: cathepsin L2-like [KO:K01365] [EC:3.4.22.15]
104385233  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
104391941  SEC61A2; protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
104392230  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
104389327  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
104393488  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
104394208  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
104394197  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
104394870  calreticulin-like [KO:K08057]
104388894  CALR3; calreticulin-3 [KO:K08057]
104386501  CANX; calnexin [KO:K08054]
104394762  Ig heavy chain Mem5-like [KO:K06856]
104389826  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
104391752  ITGB2; integrin beta-2 [KO:K06464]
104390073  COLEC11; collectin-11 isoform X1 [KO:K10066]
104397008  COLEC12; collectin-12 [KO:K10062]
104389172  SFTPD; pulmonary surfactant-associated protein D [KO:K03991]
104391944  mannose-binding protein C-like [KO:K03991]
104389160  LOW QUALITY PROTEIN: pulmonary surfactant-associated protein A-like [KO:K10067]
104389171  pulmonary surfactant-associated protein A-like [KO:K10067]
104386619  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
104398500  ITGA2; integrin alpha-2 [KO:K06481]
104397060  ITGB1; integrin beta-1 [KO:K05719]
104390236  ITGB3; integrin beta-3 [KO:K06493]
104387304  ITGB5; integrin beta-5 [KO:K06588]
104397730  THBS1; thrombospondin-1 [KO:K16857]
104395616  THBS2; thrombospondin-2 [KO:K04659]
104395688  THBS4; thrombospondin-4 [KO:K04659]
104386458  COMP; cartilage oligomeric matrix protein [KO:K04659]
104387412  THBS3; thrombospondin-3 [KO:K04659]
104387194  toll-like receptor 2 type-1 [KO:K10159]
104387195  toll-like receptor 2 type-2 [KO:K10159]
104396289  toll-like receptor 1 [KO:K10169]
104397933  TLR4; toll-like receptor 4 [KO:K10160]
104390239  MRC2; C-type mannose receptor 2 [KO:K06560]
104391878  macrophage mannose receptor 1-like [KO:K06560]
104391889  macrophage mannose receptor 1-like [KO:K06560]
104391899  macrophage mannose receptor 1-like [KO:K06560]
104391909  macrophage mannose receptor 1-like [KO:K06560]
104387349  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
104397079  macrophage mannose receptor 1-like [KO:K06560]
104394791  hepatic lectin-like [KO:K06563]
104389220  MARCO; macrophage receptor MARCO [KO:K13884]
104388761  SCARB1; scavenger receptor class B member 1 [KO:K13885]
104392394  CD36; platelet glycoprotein 4 [KO:K06259]
104388499  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104393800  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104396254  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104386110  NCF2; LOW QUALITY PROTEIN: neutrophil cytosol factor 2 [KO:K08010]
104395984  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cpea04142  Lysosome
cpea04144  Endocytosis
cpea04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

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