Entry
Name
Protein processing in endoplasmic reticulum - Cucurbita pepo subsp. pepo (vegetable marrow)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
cpep04141 Protein processing in endoplasmic reticulum
Ortholog table
Other DBs
Organism
Cucurbita pepo subsp. pepo (vegetable marrow) [GN:
cpep ]
Gene
111805295 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A-like [KO:K12666 ]
111798651 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A-like [KO:K12666 ]
111802268 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666 ]
111782915 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667 ]
111788862 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667 ]
111809745 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668 ]
111800879 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668 ]
111777645 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670 ]
111804459 probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478 ]
111809800 UDP-glucose:glycoprotein glucosyltransferase-like [KO:K11718 ] [EC:2.4.1.-]
111797222 UDP-glucose:glycoprotein glucosyltransferase-like isoform X1 [KO:K11718 ] [EC:2.4.1.-]
111781419 endoplasmic reticulum oxidoreductin-1-like [KO:K10950 ] [EC:1.8.4.-]
111803941 endoplasmic reticulum oxidoreductin-1-like [KO:K10950 ] [EC:1.8.4.-]
111793138 ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016 ]
111811446 ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1 [KO:K14016 ]
111778555 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
111794831 probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283 ]
111797033 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
111808827 probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283 ]
111808387 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
111799721 small heat shock protein, chloroplastic-like isoform X1 [KO:K13993 ]
111810870 small heat shock protein, chloroplastic-like isoform X1 [KO:K13993 ]
111790238 LOW QUALITY PROTEIN: 26.5 kDa heat shock protein, mitochondrial [KO:K13993 ]
111797104 ubiquitin thioesterase OTU1-like isoform X1 [KO:K13719 ] [EC:3.1.2.-]
111811679 ubiquitin domain-containing protein DSK2b-like isoform X1 [KO:K04523 ]
111809818 ubiquitin domain-containing protein DSK2a-like isoform X1 [KO:K04523 ]
111803072 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
111799379 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
111781583 serine/threonine-protein kinase/endoribonuclease IRE1a-like isoform X1 [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
111783115 ERAD-associated E3 ubiquitin-protein ligase component HRD3A-like [KO:K14026 ]
111802340 ERAD-associated E3 ubiquitin-protein ligase component HRD3A-like [KO:K14026 ]
Compound
Reference
Authors
Naidoo N
Title
ER and aging-Protein folding and the ER stress response.
Journal
Reference
Authors
Malhotra JD, Kaufman RJ
Title
The endoplasmic reticulum and the unfolded protein response.
Journal
Reference
Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Title
Protein quality control in the ER: the recognition of misfolded proteins.
Journal
Reference
Authors
Stolz A, Wolf DH
Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Journal
Reference
Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
Journal
Related pathway
KO pathway
LinkDB
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