KEGG   PATHWAY: cpla00260
Entry
cpla00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Chiloscyllium plagiosum (whitespotted bambooshark)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpla00260  Glycine, serine and threonine metabolism
cpla00260

Module
cpla_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cpla00260]
cpla_M00047  Creatine pathway [PATH:cpla00260]
cpla_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cpla00260]
cpla_M00555  Betaine biosynthesis, choline => betaine [PATH:cpla00260]
cpla_M00621  Glycine cleavage system [PATH:cpla00260]
cpla_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cpla00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Chiloscyllium plagiosum (whitespotted bambooshark) [GN:cpla]
Gene
122562219  tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
122560776  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
122555744  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122564573  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122564583  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122558847  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
122545661  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
122561410  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
122548262  phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
122561630  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122551579  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122561147  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
122564088  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
122542307  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
122543599  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
122545653  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
122558948  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122555144  mao; amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
122557182  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
122539867  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
122562304  gldc; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
122559156  amt; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
122563780  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122558275  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122562572  dao.2; D-amino-acid oxidase, tandem duplicate 2 [KO:K00273] [EC:1.4.3.3]
122539271  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122565398  guanidinoacetate N-methyltransferase-like [KO:K00542] [EC:2.1.1.2]
122559002  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
122560822  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122558390  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122558379  dmgdh; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
122564015  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
122548511  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
122555442  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
122540519  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
122554398  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
122564433  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
122541770  L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]
122562717  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122548958  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
122543841  serine racemase-like isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpla00010  Glycolysis / Gluconeogenesis
cpla00020  Citrate cycle (TCA cycle)
cpla00230  Purine metabolism
cpla00250  Alanine, aspartate and glutamate metabolism
cpla00270  Cysteine and methionine metabolism
cpla00290  Valine, leucine and isoleucine biosynthesis
cpla00330  Arginine and proline metabolism
cpla00470  D-Amino acid metabolism
cpla00564  Glycerophospholipid metabolism
cpla00600  Sphingolipid metabolism
cpla00620  Pyruvate metabolism
cpla00630  Glyoxylate and dicarboxylate metabolism
cpla00640  Propanoate metabolism
cpla00860  Porphyrin metabolism
cpla00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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