KEGG   PATHWAY: cpla00230
Entry
cpla00230                   Pathway                                
Name
Purine metabolism - Chiloscyllium plagiosum (whitespotted bambooshark)
Class
Metabolism; Nucleotide metabolism
Pathway map
cpla00230  Purine metabolism
cpla00230

Module
cpla_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cpla00230]
cpla_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cpla00230]
cpla_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cpla00230]
cpla_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cpla00230]
cpla_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cpla00230]
cpla_M00546  Purine degradation, xanthine => urea [PATH:cpla00230]
cpla_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cpla00230]
cpla_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cpla00230]
Other DBs
GO: 0006163 0042278
Organism
Chiloscyllium plagiosum (whitespotted bambooshark) [GN:cpla]
Gene
122560770  ADP-ribose pyrophosphatase, mitochondrial-like isoform X1 [KO:K13988] [EC:3.6.1.13]
122562791  ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
122562028  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
122562029  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
122561863  nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
122554434  pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
122551383  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
122547256  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
122555490  ribose-phosphate pyrophosphokinase 2-like [KO:K00948] [EC:2.7.6.1]
122557242  prps1b; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
122550016  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
122555362  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
122552139  pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
122550019  paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
122542338  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
122551436  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
122558315  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
122563770  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
122560810  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
122561257  nt5c2a; 5'-nucleotidase, cytosolic IIa [KO:K01081] [EC:3.1.3.5]
122554964  NAD 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
122548590  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
122540569  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
122557851  cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
122543083  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
122552947  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
122558598  pnp6; purine nucleoside phosphorylase 6 isoform X1 [KO:K03783] [EC:2.4.2.1]
122559970  pnp4a; purine nucleoside phosphorylase 4a [KO:K03783] [EC:2.4.2.1]
122554915  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
122561990  hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
122558221  peroxisomal coenzyme A diphosphatase NUDT7-like isoform X1 [KO:K00760] [EC:2.4.2.8]
122561467  inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
122559268  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
122560642  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
122560868  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
122555166  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
122562312  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
122552570  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
122540027  ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
122561251  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
122549238  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
122564689  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
122562212  cant1b; soluble calcium-activated nucleotidase 1b [KO:K12304] [EC:3.6.1.6]
122561324  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
122543042  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
122553384  entpd5a; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
122553016  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
122545443  zgc:103759; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
122554597  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
122540106  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
122559054  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
122555456  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
122555915  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
122546944  GMP reductase 2-like [KO:K00364] [EC:1.7.1.7]
122564340  GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
122563068  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
122550134  guanylate kinase-like isoform X1 [KO:K00942] [EC:2.7.4.8]
122550984  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
122563659  rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
122541317  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
122544672  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
122539294  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
122556652  zgc:110540; deoxynucleoside kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
122543151  deoxycytidine kinase 2-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
122542568  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
122548064  prune; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
122549912  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
122549721  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
122552536  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122551792  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122558411  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122549061  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122553148  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
122560628  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122551928  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
122550698  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
122555485  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
122555874  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
122559358  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
122542318  heat-stable enterotoxin receptor-like isoform X1 [KO:K12320] [EC:4.6.1.2]
122544312  retinal guanylyl cyclase 2-like isoform X1 [KO:K12322] [EC:4.6.1.2]
122557350  retinal guanylyl cyclase 2-like isoform X1 [KO:K12322] [EC:4.6.1.2]
122550941  gucy2f; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
122561397  gucy2g; guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
122554107  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
122548373  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
122539383  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
122549286  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
122551493  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
122561601  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
122557784  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
122555062  pde5ab; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
122556713  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
122539439  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
122561383  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
122555947  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
122547564  pde6gb; phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b [KO:K13759]
122542083  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma-like [KO:K13760]
122554865  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like [KO:K13761] [EC:3.1.4.35]
122540525  pde9ab; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
122551758  si:dkey-219c10.4; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
122552904  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
122549709  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
122551515  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
122553565  adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
122552654  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
122563090  AMP deaminase 2-like isoform X1 [KO:K01490] [EC:3.5.4.6]
122563297  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
122558085  AMP deaminase 3-like [KO:K01490] [EC:3.5.4.6]
122541855  adenosine kinase-like isoform X1 [KO:K00856] [EC:2.7.1.20]
122549383  adenosine deaminase-like isoform X1 [KO:K01488] [EC:3.5.4.4]
122560088  ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
122559636  ada2a; adenosine deaminase 2-A [KO:K19572] [EC:3.5.4.4]
122553377  ak7b; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
122554134  ak5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
122563561  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
122564895  ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
122564928  adenylate kinase isoenzyme 5-like isoform X1 [KO:K00939] [EC:2.7.4.3]
122558967  ak6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
122565159  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
122564698  ectonucleoside triphosphate diphosphohydrolase 2-like [KO:K01509] [EC:3.6.1.-]
122547112  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
122544234  ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
122539873  venom phosphodiesterase 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
122554420  pde4ba; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
122549418  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
122565478  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like isoform X1 [KO:K13293] [EC:3.1.4.53]
122547509  cAMP-specific 3',5'-cyclic phosphodiesterase 7B-like isoform X1 [KO:K18436] [EC:3.1.4.53]
122549444  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
122539272  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
122558485  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
122559045  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
122543894  enpp4; bis(5'-adenosyl)-triphosphatase enpp4 isoform X1 [KO:K18424] [EC:3.6.1.29]
122561052  papss2b; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b [KO:K13811] [EC:2.7.7.4 2.7.1.25]
122539261  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
122554114  uox; uricase isoform X1 [KO:K00365] [EC:1.7.3.3]
122558327  uraha; 5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
122551155  urad; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
122555741  zgc:103559; allantoinase, mitochondrial isoform X1 [KO:K01466] [EC:3.5.2.5]
122541631  allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cpla00030  Pentose phosphate pathway
cpla00220  Arginine biosynthesis
cpla00250  Alanine, aspartate and glutamate metabolism
cpla00260  Glycine, serine and threonine metabolism
cpla00340  Histidine metabolism
cpla00630  Glyoxylate and dicarboxylate metabolism
cpla00730  Thiamine metabolism
cpla00740  Riboflavin metabolism
cpla00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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