KEGG   PATHWAY: dgr00230
Entry
dgr00230                    Pathway                                
Name
Purine metabolism - Drosophila grimshawi
Class
Metabolism; Nucleotide metabolism
Pathway map
dgr00230  Purine metabolism
dgr00230

Module
dgr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:dgr00230]
dgr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:dgr00230]
dgr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:dgr00230]
dgr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:dgr00230]
dgr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:dgr00230]
dgr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:dgr00230]
dgr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:dgr00230]
Other DBs
GO: 0006163 0042278
Organism
Drosophila grimshawi [GN:dgr]
Gene
6558588  ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
6557719  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
6569105  glucose 1,6-bisphosphate synthase [KO:K01835] [EC:5.4.2.2]
6560880  glucose 1,6-bisphosphate synthase [KO:K01835] [EC:5.4.2.2]
6571104  glucose 1,6-bisphosphate synthase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
6557047  ribose-phosphate pyrophosphokinase 2 isoform X2 [KO:K00948] [EC:2.7.6.1]
6557486  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
6563686  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
6566505  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
6562319  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
6565145  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
6556727  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
6569594  bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
6558870  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
6559575  mannosylglucosyl-3-phosphoglycerate phosphatase isoform X3 [KO:K01081] [EC:3.1.3.5]
6569297  apyrase isoform X2 [KO:K01081] [EC:3.1.3.5]
6565416  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
6560856  protein 5NUC [KO:K19970] [EC:3.1.3.5]
6560857  protein 5NUC [KO:K19970] [EC:3.1.3.5]
6560310  protein 5NUC [KO:K19970] [EC:3.1.3.5]
6560728  protein 5NUC isoform X1 [KO:K19970] [EC:3.1.3.5]
122322443  protein 5NUC-like [KO:K19970] [EC:3.1.3.5]
6561292  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
6556749  purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
6564764  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
6563507  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
6563061  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
6565133  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
6569714  fibrous sheath CABYR-binding protein [KO:K00940] [EC:2.7.4.6]
6568465  soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
6562799  ectonucleoside triphosphate diphosphohydrolase 5 isoform X4 [KO:K01511] [EC:3.6.1.6]
6566606  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
6563390  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563145  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563581  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563012  aldehyde oxidase 4 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563013  aldehyde oxidase 4 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6570992  aldehyde oxidase 4 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563146  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6563583  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
6562399  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
6562679  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
6564090  guanine deaminase [KO:K01487] [EC:3.5.4.3]
6558797  guanylate kinase [KO:K00942] [EC:2.7.4.8]
6567018  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
6560075  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
6567124  uncharacterized protein LOC6567124 [KO:K07023] [EC:3.1.3.89]
6568426  deoxynucleoside kinase isoform X3 [KO:K05961] [EC:2.7.1.145]
6569740  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
6564643  uncharacterized protein LOC6564643 [KO:K01514] [EC:3.6.1.11]
6569280  exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
6556827  adenylyl cyclase X E isoform X1 [KO:K01768] [EC:4.6.1.1]
6558659  adenylate cyclase type 7 isoform X1 [KO:K01768] [EC:4.6.1.1]
6564853  Ca(2+)/calmodulin-responsive adenylate cyclase isoform X1 [KO:K08041] [EC:4.6.1.1]
6557116  adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
6562956  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
6558351  adenylyl cyclase 78C [KO:K08048] [EC:4.6.1.1]
6565535  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
6564101  head-specific guanylate cyclase [KO:K12318] [EC:4.6.1.2]
6569794  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
6564343  uncharacterized protein LOC6564343 [KO:K12322] [EC:4.6.1.2]
6559935  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
6571759  atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
6563530  soluble guanylate cyclase 89Da [KO:K01769] [EC:4.6.1.2]
6563531  soluble guanylate cyclase 89Db [KO:K01769] [EC:4.6.1.2]
6568382  soluble guanylate cyclase 88E [KO:K01769] [EC:4.6.1.2]
6562011  guanylate cyclase 32E isoform X1 [KO:K01769] [EC:4.6.1.2]
6556550  receptor-type guanylate cyclase Gyc76C-like [KO:K01769] [EC:4.6.1.2]
6566658  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 isoform X2 [KO:K13755] [EC:3.1.4.17]
6561432  probable cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
6569905  cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13763] [EC:3.1.4.35]
6562344  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
6568148  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
6569194  LOW QUALITY PROTEIN: AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
6559587  adenosine kinase [KO:K00856] [EC:2.7.1.20]
6568608  adenosine kinase [KO:K00856] [EC:2.7.1.20]
6570379  adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
6556549  adenosine deaminase 2 isoform X1 [KO:K01488] [EC:3.5.4.4]
6563519  adenosine deaminase-like protein [KO:K01488] [EC:3.5.4.4]
6568937  adenosine deaminase 2 isoform X1 [KO:K01488] [EC:3.5.4.4]
6569859  adenosine deaminase 2 isoform X2 [KO:K01488] [EC:3.5.4.4]
6556521  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
6556527  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
6569895  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
6558403  adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
6559468  adenylate kinase [KO:K00939] [EC:2.7.4.3]
6561129  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
6558835  nucleoside-triphosphatase THEP1 [KO:K06928] [EC:3.6.1.15]
6565661  cAMP-specific 3',5'-cyclic phosphodiesterase isoform X7 [KO:K13293] [EC:3.1.4.53]
6560609  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1 [KO:K18437] [EC:3.1.4.53]
6558524  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase isoform X3 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
6563033  uricase [KO:K00365] [EC:1.7.3.3]
6563721  uricase [KO:K00365] [EC:1.7.3.3]
6560163  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
6569540  allantoinase [KO:K01466] [EC:3.5.2.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
dgr00030  Pentose phosphate pathway
dgr00220  Arginine biosynthesis
dgr00250  Alanine, aspartate and glutamate metabolism
dgr00260  Glycine, serine and threonine metabolism
dgr00340  Histidine metabolism
dgr00630  Glyoxylate and dicarboxylate metabolism
dgr00730  Thiamine metabolism
dgr00740  Riboflavin metabolism
dgr00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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