KEGG   PATHWAY: dpz03013
Entry
dpz03013                    Pathway                                
Name
Nucleocytoplasmic transport - Daphnia pulicaria
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
dpz03013  Nucleocytoplasmic transport
dpz03013

Other DBs
GO: 0050658
Organism
Daphnia pulicaria [GN:dpz]
Gene
124341496  aladin-like [KO:K14320]
124311284  nucleoporin NUP42-like isoform X1 [KO:K14321]
124348978  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
124311262  protein Rae1-like [KO:K14298]
124310834  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
124348889  nuclear pore complex protein Nup88-like [KO:K14318]
124342541  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
124320311  ran GTPase-activating protein 1-like [KO:K14319]
124344237  SUMO-conjugating enzyme UBC9-B [KO:K10577]
124328962  small ubiquitin-related modifier-like [KO:K12160]
124340630  nuclear pore complex protein Nup160-like [KO:K14303]
124325975  nuclear pore complex protein Nup85-like [KO:K14304]
124337113  protein SEC13 homolog [KO:K14004]
124337690  protein SEC13 homolog [KO:K14004]
124332636  nuclear pore complex protein Nup107-like [KO:K14301]
124315120  nuclear pore complex protein Nup133-like [KO:K14300]
124338053  nucleoporin SEH1-like [KO:K14299]
124349883  nucleoporin Nup37-like [KO:K14302]
124349361  protein ELYS-like isoform X1 [KO:K25129]
124320646  nucleoporin p58/p45-like isoform X1 [KO:K14307]
124343044  nuclear pore complex protein Nup54-like [KO:K14308]
124314396  nuclear pore complex protein Nup205-like [KO:K14310]
124321162  nucleoporin NUP188-like [KO:K14311]
124336645  nuclear pore complex protein Nup155-like [KO:K14312]
124327029  nuclear pore complex protein Nup93-like [KO:K14309]
124351471  nucleoporin NUP35-like [KO:K14313]
124312102  nucleoporin NDC1-like [KO:K14315]
124331340  nuclear pore membrane glycoprotein 210-like [KO:K14314]
124320411  transmembrane protein 33-like [KO:K20724]
124337130  transmembrane protein 33-like isoform X1 [KO:K20724]
124340586  nucleoprotein TPR-like [KO:K09291]
124335808  nuclear pore complex protein Nup50-like [KO:K14295]
124313064  importin subunit alpha-5-like [KO:K15043]
124342686  importin subunit alpha-5-like isoform X1 [KO:K15043]
124346603  importin subunit alpha-1-like [KO:K15043]
124348634  importin subunit alpha-5-like [KO:K15043]
124328519  importin subunit alpha-5-like isoform X1 [KO:K15043]
124340515  importin subunit alpha-5-like isoform X1 [KO:K15043]
124336999  importin subunit alpha-3-like [KO:K23583]
124334422  importin subunit alpha-6-like [KO:K15042]
124349028  uncharacterized protein LOC124349028 isoform X1 [KO:K15042]
124337888  importin subunit beta-1-like [KO:K14293]
124310896  uncharacterized protein LOC124310896 isoform X1 [KO:K14293]
124310897  uncharacterized protein LOC124310897 isoform X1 [KO:K14293]
124329025  importin subunit beta-1-like [KO:K14293]
124327791  transportin-1-like [KO:K18752]
124325894  transportin-3-like [KO:K15436]
124312287  importin-4-like [KO:K20221]
124340824  importin-5-like [KO:K20222]
124320239  importin-7-like [KO:K20223]
124327502  importin-9-like isoform X1 [KO:K20224]
124312259  importin-11-like [KO:K25201]
124313985  importin-13-like [KO:K25202]
124336215  snurportin-1-like [KO:K13151]
124312826  exportin-1-like [KO:K14290]
124325983  exportin-1-like [KO:K14290]
124343146  exportin-2-like [KO:K18423]
124312061  exportin-T-like [KO:K14288]
124313979  exportin-4-like [KO:K25203]
124338196  exportin-5-like [KO:K14289]
124321301  exportin-6-like [KO:K25204]
124337873  exportin-7-like isoform X1 [KO:K18460]
124337642  GTP-binding nuclear protein Ran [KO:K07936]
124313076  elongation factor 1-alpha-like [KO:K03231]
124313077  elongation factor 1-alpha [KO:K03231]
124312575  phosphorylated adapter RNA export protein-like [KO:K14291]
124314008  nuclear cap-binding protein subunit 1-like [KO:K12882]
124316572  nuclear cap-binding protein subunit 2-like [KO:K12883]
124311132  60S ribosomal export protein NMD3-like [KO:K07562]
124321173  RNA-binding protein 8A-like [KO:K12876]
124350119  protein mago nashi homolog [KO:K12877]
124336067  protein CASC3-like isoform X1 [KO:K14323]
124343270  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
124336035  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
124343354  histone deacetylase complex subunit SAP18-like [KO:K14324]
124349878  RNA-binding protein with serine-rich domain 1-B-like isoform X1 [KO:K14325]
124311256  pinin-like [KO:K13114]
124349944  THO complex subunit 4-like [KO:K12881]
124340819  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
124320233  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
124341668  regulator of nonsense transcripts 3B-like isoform X1 [KO:K14328]
124321246  nuclear RNA export factor 1-like [KO:K14284]
124334568  nuclear RNA export factor 1-like [KO:K14284]
124342135  NTF2-related export protein 1-like [KO:K14285]
124328346  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
124312914  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
124312916  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
124349076  partner of Y14 and mago-like [KO:K14294]
124335865  THO complex subunit 1-like isoform X1 [KO:K12878]
124342055  THO complex subunit 2-like [KO:K12879]
124328987  THO complex subunit 2-like isoform X1 [KO:K12879]
124338089  THO complex subunit 5 homolog [KO:K13174]
124313216  THO complex subunit 6 homolog [KO:K13175]
124315625  THO complex subunit 7 homolog [KO:K13176]
124349884  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
dpz03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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