KEGG   PATHWAY: eee04145
Entry
eee04145                    Pathway                                
Name
Phagosome - Electrophorus electricus (electric eel)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
eee04145  Phagosome
eee04145

Other DBs
GO: 0045335
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113592379  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
113584030  syntaxin-12-like [KO:K13813]
113588155  syntaxin-12-like [KO:K13813]
113592314  stx7; syntaxin-7 [KO:K08488]
113580904  actin, cytoplasmic 1 [KO:K05692]
113585569  actb; actin, cytoplasmic 1 [KO:K05692]
113590063  coronin-1A-like [KO:K13882]
113574054  stx18; syntaxin-18 [KO:K08492]
113586342  sec22b; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
113568801  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
113588762  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113568887  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
113568897  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113568924  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
113569031  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569108  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113583839  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
113592081  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569159  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
113567983  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569316  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569330  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113569334  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569366  RT1 class I histocompatibility antigen, AA alpha chain-like [KO:K06751]
113568289  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
113568574  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113568606  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113583829  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
113583838  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
113568290  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113567674  H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752]
113567675  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
113568075  H-2 class II histocompatibility antigen, A-S alpha chain-like [KO:K06752]
113568076  LOW QUALITY PROTEIN: rano class II histocompatibility antigen, D-1 beta chain-like [KO:K06752]
113568077  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
113568078  H-2 class II histocompatibility antigen, A-K alpha chain-like [KO:K06752]
113568310  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
113568313  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
113588725  ras-related protein Rab-5A [KO:K07887]
113578813  ras-related protein Rab-5A-like [KO:K07887]
113567539  ras-related protein Rab-5B-like [KO:K07888]
113581775  ras-related protein Rab-5C-like [KO:K07889]
113591521  ras-related protein Rab-5C-like [KO:K07889]
113590570  eea1; early endosome antigen 1 [KO:K12478]
113578319  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
113590665  tfrc; transferrin receptor protein 1 [KO:K06503]
113576148  transferrin receptor protein 1-like isoform X1 [KO:K06503]
113590114  transferrin receptor protein 1-like [KO:K06503]
113587851  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
113576113  atp6v1a; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
113570270  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
113586456  V-type proton ATPase subunit B, brain isoform [KO:K02147]
113576338  V-type proton ATPase subunit B, brain isoform [KO:K02147]
113580040  atp6v1c1; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 1 [KO:K02148]
113580828  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
113586258  V-type proton ATPase subunit E 1-like [KO:K02150]
113589250  V-type proton ATPase subunit E 1-like [KO:K02150]
113579976  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
113572462  V-type proton ATPase subunit G 1-like [KO:K02152]
113578970  V-type proton ATPase subunit e 2-like [KO:K02153]
113577150  V-type proton ATPase subunit e 2-like [KO:K02153]
113591826  atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
113584812  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
113589966  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113571496  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113583015  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113571921  atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113582734  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
113589420  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
113580241  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
113567768  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
113584666  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
113581385  V-type proton ATPase subunit S1-like isoform X1 [KO:K03662]
113572318  atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
113576002  rab7a; ras-related protein Rab-7a [KO:K07897]
113589948  ras-related protein rab7 [KO:K07897]
113572358  ras-related protein rab7-like [KO:K07897]
113578160  ras-related protein rab7-like [KO:K07897]
113589400  RILP-like protein 1 [KO:K13883]
113587268  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
113578673  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
113575675  cytoplasmic dynein 1 intermediate chain 1-like isoform X1 [KO:K10415]
113570388  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
113588397  dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
113588461  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
113580410  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
113588693  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
113588694  tubulin alpha-1B chain [KO:K07374]
113572092  tubulin alpha chain, testis-specific-like [KO:K07374]
113578577  tubulin alpha-1C chain isoform X1 [KO:K07374]
113578583  tubulin alpha-1A chain [KO:K07374]
113583891  tubulin alpha chain, testis-specific-like [KO:K07374]
113580047  tubulin alpha chain isoform X1 [KO:K07374]
113584283  tubulin alpha chain-like [KO:K07374]
113584284  tubulin alpha chain-like [KO:K07374]
113579196  tubulin alpha chain-like [KO:K07374]
113590646  tubulin alpha chain-like isoform X1 [KO:K07374]
113577863  tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
113586197  tubulin beta-1 chain isoform X1 [KO:K07375]
113568359  tubulin beta chain-like [KO:K07375]
113570868  tubb3; tubulin beta-3 chain [KO:K07375]
113579381  tubulin beta-5 chain [KO:K07375]
113578529  tubulin beta-4 chain-like isoform X1 [KO:K07375]
113581365  tubulin beta-4B chain-like [KO:K07375]
113591923  tubulin beta-4B chain-like [KO:K07375]
113567646  tubulin beta-4 chain-like [KO:K07375]
113587855  tubulin beta-1 chain-like [KO:K07375]
113570238  tubb4b; tubulin beta-4B chain [KO:K07375]
113576835  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
113582653  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
113574344  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
113572052  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
113575279  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
113577767  nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
113589718  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
113567712  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
113574513  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113576047  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113590155  cathepsin L1-like [KO:K01368] [EC:3.4.22.27]
113575272  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
113575977  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
113590841  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
113589252  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
113578824  tap1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
113581264  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
113579422  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
113581087  calreticulin-like [KO:K08057]
113577794  calreticulin-like [KO:K08057]
113585979  calreticulin-like [KO:K08057]
113584811  canx; calnexin [KO:K08054]
113574193  calnexin-like isoform X1 [KO:K08054]
113588299  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
113574789  complement C1r-A subcomponent-like [KO:K01330] [EC:3.4.21.41]
113587515  integrin alpha-X-like isoform X1 [KO:K06461]
113577217  integrin beta-2-like [KO:K06464]
113591926  complement C3-like [KO:K03990]
113586552  colec11; collectin-11 [KO:K10066]
113591646  collectin-12-like isoform X1 [KO:K10062]
113580008  colec12; collectin-12 [KO:K10062]
113584151  mannose-binding protein A-like [KO:K03991]
113588804  itgav; integrin alpha-V [KO:K06487]
113576211  itga2; integrin alpha-2 [KO:K06481]
113576413  itga5; integrin alpha-5 [KO:K06484]
113568006  integrin beta-1-like isoform X1 [KO:K05719]
113574768  itgb1; integrin beta-1 [KO:K05719]
113573277  integrin beta-3-like [KO:K06493]
113572826  itgb3; integrin beta-3 [KO:K06493]
113577112  itgb5; integrin beta-5 [KO:K06588]
113571350  thrombospondin-1-like [KO:K16857]
113570532  thrombospondin-1-like isoform X1 [KO:K16857]
113571180  thbs3; thrombospondin-3 [KO:K04659]
113577667  thrombospondin-2-like [KO:K04659]
113581906  comp; cartilage oligomeric matrix protein [KO:K04659]
113590190  thrombospondin-4-B [KO:K04659]
113579963  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
113575012  thrombospondin-4-B-like isoform X1 [KO:K04659]
113588569  LOW QUALITY PROTEIN: thrombospondin-3b-like [KO:K04659]
113583650  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
113589619  toll-like receptor 2 type-1 [KO:K10159]
113580436  macrophage mannose receptor 1-like [KO:K06560]
113582529  pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
113588709  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
113573235  mrc2; C-type mannose receptor 2 [KO:K06560]
113579709  macrophage mannose receptor 1-like [KO:K06560]
113583179  mrc1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
113586287  macrophage mannose receptor 1-like [KO:K06560]
113591648  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
113590179  CD209 antigen-like protein C [KO:K06563]
113584295  marco; macrophage receptor MARCO [KO:K13884]
113584145  scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
113569320  cd36; platelet glycoprotein 4 [KO:K06259]
113570890  cytochrome b-245 light chain [KO:K08009]
113578253  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
113584625  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113575309  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113573777  ncf1; neutrophil cytosol factor 1 [KO:K08011]
113583185  ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
113585725  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
eee04142  Lysosome
eee04144  Endocytosis
eee04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
LinkDB

DBGET integrated database retrieval system