KEGG   PATHWAY: elk04150
Entry
elk04150                    Pathway                                
Name
mTOR signaling pathway - Enhydra lutris kenyoni (northern sea otter)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
elk04150  mTOR signaling pathway
elk04150

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111152998  large neutral amino acids transporter small subunit 1 [KO:K13780]
111149601  4F2 cell-surface antigen heavy chain [KO:K06519]
111156969  sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
111151188  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
111148052  V-type proton ATPase subunit B, kidney isoform [KO:K02147]
111155049  V-type proton ATPase subunit B, brain isoform [KO:K02147]
111146645  V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
111154195  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
111148774  V-type proton ATPase subunit D isoform X1 [KO:K02149]
111159822  V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
111155954  V-type proton ATPase subunit E 2 [KO:K02150]
111152026  V-type proton ATPase subunit F [KO:K02151]
111142544  V-type proton ATPase subunit G 1-like isoform X1 [KO:K02152]
111151163  V-type proton ATPase subunit G 3 [KO:K02152]
111152277  V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
111146191  V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
111155413  V-type proton ATPase subunit H isoform X1 [KO:K02144]
111159426  ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
111138850  ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
111155377  ragulator complex protein LAMTOR3 [KO:K04370]
111145766  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
111143143  ragulator complex protein LAMTOR5 [KO:K16344]
111139249  folliculin [KO:K09594]
111140883  folliculin-interacting protein 1 isoform X1 [KO:K20400]
111156996  folliculin-interacting protein 2 isoform X1 [KO:K20401]
111139787  ras-related GTP-binding protein B isoform X1 [KO:K16185]
111156601  ras-related GTP-binding protein A [KO:K16185]
111158818  ras-related GTP-binding protein D [KO:K16186]
111143073  ras-related GTP-binding protein C isoform X1 [KO:K16186]
111143115  sestrin-2 [KO:K20394]
111160035  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
111145850  LOW QUALITY PROTEIN: cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
111147182  GATOR complex protein MIOS [KO:K20407]
111142644  nucleoporin SEH1 isoform X1 [KO:K14299]
111156192  GATOR complex protein WDR24 [KO:K20408]
111152772  GATOR complex protein WDR59 isoform X1 [KO:K20409]
111143848  protein SEC13 homolog [KO:K14004]
111160011  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
111143766  GATOR complex protein NPRL2 [KO:K20405]
111156113  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
111140933  S-phase kinase-associated protein 2 [KO:K03875]
111154287  E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
111160429  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111160809  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111146641  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
111156180  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
111156227  telomere length regulation protein TEL2 homolog [KO:K11137]
111141435  TELO2-interacting protein 1 homolog [KO:K20403]
111156336  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
111157052  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
111142445  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
111154084  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
111141402  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
111140006  serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
111139478  serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
111144538  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111146502  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
111146503  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
111157179  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
111150366  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111141077  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
111149588  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111151757  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111157728  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111156567  40S ribosomal protein S6 [KO:K02991]
111148822  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
111158023  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
111141649  STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
111161896  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
111147045  calcium-binding protein 39-like [KO:K08272]
111141812  calcium-binding protein 39 [KO:K08272]
111143318  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
111141175  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
111145731  hamartin isoform X1 [KO:K07206]
111156259  tuberin isoform X1 [KO:K07207]
111156707  TBC1 domain family member 7 isoform X1 [KO:K20396]
111154404  GTP-binding protein Rheb [KO:K07208]
111145063  DNA damage-inducible transcript 4 protein [KO:K08270]
111158015  proto-oncogene Wnt-1 [KO:K03209]
111143458  protein Wnt-2b [KO:K00182]
111152038  protein Wnt-2 [KO:K00182]
111139433  protein Wnt-3a [KO:K00312]
111158156  proto-oncogene Wnt-3 [KO:K00312]
111154909  protein Wnt-4 [KO:K00408]
111159795  protein Wnt-5b [KO:K00444]
111144172  protein Wnt-5a isoform X1 [KO:K00444]
111145739  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
111157688  protein Wnt-7b isoform X1 [KO:K00572]
111159004  protein Wnt-7a [KO:K00572]
111141267  protein Wnt-8a [KO:K00714]
111145241  protein Wnt-8b [KO:K00714]
111139428  protein Wnt-9a [KO:K01064]
111158202  LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
111157990  protein Wnt-10b [KO:K01357]
111144711  protein Wnt-10a [KO:K01357]
111159478  protein Wnt-11 [KO:K01384]
111152110  protein Wnt-16 [KO:K01558]
111141425  frizzled-7 [KO:K02432]
111147325  frizzled-1 [KO:K02432]
111158141  frizzled-2 [KO:K02235]
111156239  frizzled-3 [KO:K02329]
111154467  frizzled-4 [KO:K02354]
111155536  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
111143924  frizzled-5 [KO:K02375]
111146642  frizzled-6 [KO:K02376]
111156537  frizzled-10 [KO:K02842]
111146438  frizzled-9 [KO:K02842]
111142027  low-density lipoprotein receptor-related protein 6 [KO:K03068]
111149489  low-density lipoprotein receptor-related protein 5 [KO:K03068]
111154625  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111161117  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
111148907  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
111149303  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111159748  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111150279  insulin [KO:K04526]
111142293  insulin-like growth factor I [KO:K05459]
111142036  insulin-like growth factor I isoform X1 [KO:K05459]
111161798  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111152643  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111151941  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111139440  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111150451  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111158720  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
111154593  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111143995  insulin receptor substrate 1 [KO:K16172]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111156293  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111145709  target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
111140909  rapamycin-insensitive companion of mTOR [KO:K08267]
111157574  proline-rich protein 5 isoform X1 [KO:K20411]
111149991  proline-rich protein 5-like [KO:K20411]
111144026  transforming protein RhoA isoform X1 [KO:K04513]
111158087  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111162208  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111139613  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
111147659  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
elk00561  Glycerolipid metabolism
elk04010  MAPK signaling pathway
elk04140  Autophagy - animal
elk04151  PI3K-Akt signaling pathway
elk04152  AMPK signaling pathway
elk04810  Regulation of actin cytoskeleton
elk04910  Insulin signaling pathway
KO pathway
ko04150   
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