KEGG   PATHWAY: elk04540
Entry
elk04540                    Pathway                                
Name
Gap junction - Enhydra lutris kenyoni (northern sea otter)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
elk04540  Gap junction
elk04540

Other DBs
GO: 0005921
Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111147558  gap junction alpha-1 protein [KO:K07372]
111150445  gap junction alpha-1 protein-like [KO:K07372]
111140631  gap junction delta-2 protein [KO:K07373]
111145805  lysophosphatidic acid receptor 1 [KO:K04289]
111155312  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111143783  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111143343  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
111145884  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111157534  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111155335  platelet-derived growth factor C [KO:K05450]
111153783  platelet-derived growth factor D isoform X1 [KO:K05450]
111156359  pro-epidermal growth factor isoform X1 [KO:K04357]
111148924  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111140848  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111141563  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111160868  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111153163  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111139244  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
111143142  tubulin alpha-4A chain [KO:K07374]
111142067  tubulin alpha-1A chain-like [KO:K07374]
111157712  tubulin alpha-1B chain [KO:K07374]
111157713  tubulin alpha-1A chain [KO:K07374]
111158883  tubulin alpha-1A chain-like [KO:K07374]
111159721  tubulin alpha-8 chain isoform X1 [KO:K07374]
111157791  tubulin alpha-1C chain [KO:K07374]
111144980  putative tubulin-like protein alpha-4B [KO:K07374]
111151071  tubulin alpha-8 chain isoform X1 [KO:K07374]
111158635  LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
111142377  tubulin alpha-3 chain [KO:K07374]
111142381  tubulin alpha-3 chain [KO:K07374]
111141694  tubulin beta-1 chain [KO:K07375]
111142513  tubulin beta-6 chain isoform X1 [KO:K07375]
111161751  tubulin beta-4A chain isoform X1 [KO:K07375]
111156662  tubulin beta-2A chain isoform X1 [KO:K07375]
111152799  tubulin beta-3 chain [KO:K07375]
111156744  tubulin beta-2B chain isoform X1 [KO:K07375]
111146420  tubulin beta-4B chain isoform X1 [KO:K07375]
111152509  tubulin beta chain isoform X1 [KO:K07375]
111160246  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
111144961  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111152592  tight junction protein ZO-1 isoform X1 [KO:K05701]
111145258  beta-1 adrenergic receptor [KO:K04141]
111141234  D(1A) dopamine receptor [KO:K04144]
111141614  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
111141312  neuroendocrine secretory protein 55 [KO:K04632]
111153852  D(2) dopamine receptor isoform X1 [KO:K04145]
111157054  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111153427  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111154044  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111162403  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111155044  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111157825  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111157326  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111146667  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111156133  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111162516  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111143399  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111147086  5-hydroxytryptamine receptor 2A [KO:K04157]
111143984  5-hydroxytryptamine receptor 2B [KO:K04157]
111160970  5-hydroxytryptamine receptor 2C [KO:K04157]
111147676  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
111154498  metabotropic glutamate receptor 5 [KO:K04604]
111161857  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
111153498  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111141432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111162302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111141620  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111150005  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111144005  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111159979  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111152507  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111158087  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111162208  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111139613  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
111153821  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
111155838  guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
111147095  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
111154115  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
111145213  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
111149130  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
elk04010  MAPK signaling pathway
elk04020  Calcium signaling pathway
elk04060  Cytokine-cytokine receptor interaction
elk04070  Phosphatidylinositol signaling system
elk04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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