KEGG   PATHWAY: els03015
Entry
els03015                    Pathway                                
Name
mRNA surveillance pathway - Esox lucius (northern pike)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
els03015  mRNA surveillance pathway
els03015

Other DBs
GO: 0071028
Organism
Esox lucius (northern pike) [GN:els]
Gene
105028015  ncbp1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
105011987  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
105031343  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
105025497  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
105019282  rbm8a; RNA-binding protein 8A [KO:K12876]
105005904  magoh; protein mago nashi homolog [KO:K12877]
105013269  casc3; protein CASC3 isoform X1 [KO:K14323]
105008739  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
105019766  sap18; Sin3A-associated protein, 18kDa [KO:K14324]
105016423  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
105015487  pnn; pinin [KO:K13114]
105020563  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
105021555  acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
114830399  uncharacterized protein LOC114830399 [KO:K12875]
105007889  RNA-binding protein with serine-rich domain 1 isoform X2 [KO:K14325]
105027496  rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
105012898  THO complex subunit 4 [KO:K12881]
105021606  THO complex subunit 4-A [KO:K12881]
105013668  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
105030692  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
105014169  gle1; nucleoporin GLE1 [KO:K18723]
105010949  nxf1; nuclear RNA export factor 1 [KO:K14284]
105026736  nuclear RNA export factor 1 isoform X1 [KO:K14284]
105024405  nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
105012335  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
105022318  pym1; partner of Y14 and mago [KO:K14294]
105015814  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105017860  rngtt; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
105030541  rnmt; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
105011361  RNA-binding protein FUS isoform X1 [KO:K13098]
105030395  RNA-binding protein FUS isoform X1 [KO:K13098]
105022966  tardbp; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
105025427  TAR DNA-binding protein 43-like isoform X1 [KO:K23600]
105017077  pabpn1l; embryonic polyadenylate-binding protein 2 [KO:K14396]
105019495  pabpn1; polyadenylate-binding protein 2 isoform X1 [KO:K14396]
105016251  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
105018441  cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
105022255  cpsf7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
105023121  cpsf6; cleavage and polyadenylation specificity factor subunit 6 isoform X6 [KO:K14398]
105008533  papolg; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
105024317  papola; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
105028688  clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
105006049  pcf11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
105012753  cpsf1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
105017560  cpsf2; cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
105017804  cpsf3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
105031073  cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
105011833  fip1l1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
105020871  pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
105023233  wdr33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
105028835  wdr82; WD repeat-containing protein 82 [KO:K14962]
105016858  WD repeat-containing protein 82 [KO:K14962]
105012949  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
105020693  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105024808  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105014191  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105024386  serine/threonine-protein phosphatase alpha-2 isoform isoform X1 [KO:K06269] [EC:3.1.3.16]
105017109  ssu72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
105007594  cstf1; cleavage stimulation factor subunit 1 [KO:K14406]
105029800  cstf2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
105014273  cstf3; cleavage stimulation factor subunit 3 [KO:K14408]
105010849  sympk; symplekin [KO:K06100]
105017060  RNA-binding protein Musashi homolog 1 isoform X2 [KO:K14411]
105014213  msi1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
105029302  dazap1; DAZ-associated protein 1 isoform X1 [KO:K14411]
105013285  RNA-binding protein Musashi homolog 2 isoform X2 [KO:K14411]
105028669  RNA-binding protein Musashi homolog 2 isoform X2 [KO:K14411]
105008385  embryonic polyadenylate-binding protein isoform X2 [KO:K13126]
105016474  polyadenylate-binding protein 1 [KO:K13126]
114839351  polyadenylate-binding protein 1-like [KO:K13126]
105006547  polyadenylate-binding protein 1 isoform X1 [KO:K13126]
105015806  pabpc4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
105030478  polyadenylate-binding protein 1-like [KO:K13126]
105026176  eukaryotic peptide chain release factor subunit 1 isoform X2 [KO:K03265]
105029257  eukaryotic peptide chain release factor subunit 1 [KO:K03265]
105013069  eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
105025103  gspt1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
105024419  regulator of nonsense transcripts 1 isoform X3 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105026208  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105020176  upf2; regulator of nonsense transcripts 2 isoform X3 [KO:K14327]
105030485  smg1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
105018103  smg7; protein SMG7 isoform X1 [KO:K14409]
105019277  smg5; protein SMG5 isoform X1 [KO:K11125]
105031156  smg6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
105025380  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105021738  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105026079  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105026695  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105011486  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105011263  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105009682  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
105010580  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform-like [KO:K04354]
105024168  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
105025215  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105024420  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105020827  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
105015482  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105028558  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
105019852  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105006352  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105015335  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105030679  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105015552  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105025507  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105015991  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
105018001  hbs1l; HBS1-like protein isoform X1 [KO:K14416]
105024388  pelo; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
els03013  Nucleocytoplasmic transport
els03018  RNA degradation
els03040  Spliceosome
KO pathway
ko03015   
LinkDB

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