KEGG   PATHWAY: esp04070
Entry
esp04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Etheostoma spectabile (orangethroat darter)
Class
Environmental Information Processing; Signal transduction
Pathway map
esp04070  Phosphatidylinositol signaling system
esp04070

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116689048  phosphatidylinositol 4-kinase alpha-like isoform X1 [KO:K00888] [EC:2.7.1.67]
116704028  phosphatidylinositol 4-kinase alpha-like [KO:K00888] [EC:2.7.1.67]
116702274  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
116704226  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha isoform X1 [KO:K13711] [EC:2.7.1.67]
116702089  phosphatidylinositide phosphatase SAC1-A [KO:K21797] [EC:3.1.3.-]
116683571  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
116691384  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116699144  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116701654  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116696108  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116689248  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
116703860  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116691415  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
116696704  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
116689123  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
116700363  synj1; synaptojanin-1 [KO:K20279] [EC:3.1.3.36]
116675754  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116678381  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116699195  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116692529  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116695417  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
116698567  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116699207  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
116695430  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116696146  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
116689915  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
116704085  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116705301  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116695746  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
116697285  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
116684057  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
116697730  inpp4a; inositol polyphosphate-4-phosphatase type I A isoform X1 [KO:K01109] [EC:3.1.3.66]
116669708  inpp4b; inositol polyphosphate 4-phosphatase type II isoform X1 [KO:K01109] [EC:3.1.3.66]
116673951  LOW QUALITY PROTEIN: inositol polyphosphate-4-phosphatase type I A-like [KO:K01109] [EC:3.1.3.66]
116688950  pikfyve; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
116707182  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
116707178  LOW QUALITY PROTEIN: myotubularin-related protein 2-like [KO:K18081] [EC:3.1.3.64 3.1.3.95]
116700612  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
116700066  mtmr4; LOW QUALITY PROTEIN: myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
116686669  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
116689314  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
116697106  mtmr7; myotubularin-related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
116701138  myotubularin-related protein 7-like isoform X1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
116672114  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
116687892  mtmr14; LOW QUALITY PROTEIN: myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
116679824  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like isoform X1 [KO:K00920] [EC:2.7.1.149]
116693290  pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
116687234  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like isoform X1 [KO:K00920] [EC:2.7.1.149]
116694890  pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
116672053  pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
116698603  pip4p1; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
116669519  type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B-like [KO:K13084] [EC:3.1.3.78]
116701796  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
116706994  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
116693588  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
116694205  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
116705016  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
116706249  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116706250  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
116686556  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
116670665  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116673665  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
116698222  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
116698924  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116671514  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116702768  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116672481  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
116671264  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116692557  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116695236  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
116693373  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like isoform X1 [KO:K05859] [EC:3.1.4.11]
116693374  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like isoform X1 [KO:K05859] [EC:3.1.4.11]
116694206  plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
116704607  inositol polyphosphate multikinase-like [KO:K00915] [EC:2.7.1.140 2.7.1.151]
116671522  inositol polyphosphate multikinase-like [KO:K00915] [EC:2.7.1.140 2.7.1.151]
116677535  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116705917  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
116670036  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116696977  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116700194  inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
116705180  inpp5a; inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
116681334  inositol-tetrakisphosphate 1-kinase-like [KO:K00913] [EC:2.7.1.159 2.7.1.134]
116670676  itpk1; inositol-tetrakisphosphate 1-kinase isoform X1 [KO:K00913] [EC:2.7.1.159 2.7.1.134]
116688521  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
116687540  ip6k1; LOW QUALITY PROTEIN: inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
116688383  ip6k2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
116688630  inositol hexakisphosphate kinase 2-like isoform X1 [KO:K07756] [EC:2.7.4.21]
116686934  ppip5k1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
116694146  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2-like isoform X1 [KO:K13024] [EC:2.7.4.24]
116688508  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
116672167  inositol monophosphatase 1-like [KO:K01092] [EC:3.1.3.25]
116672168  impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
116699336  inositol monophosphatase 3-like [KO:K15759] [EC:3.1.3.7]
116700278  bpnt2; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase [KO:K15759] [EC:3.1.3.7]
116673339  diacylglycerol kinase iota-like isoform X1 [KO:K00901] [EC:2.7.1.107]
116673674  dgkz; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
116690924  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
116678966  LOW QUALITY PROTEIN: diacylglycerol kinase zeta-like [KO:K00901] [EC:2.7.1.107]
116692058  diacylglycerol kinase alpha-like [KO:K00901] [EC:2.7.1.107]
116679869  diacylglycerol kinase alpha-like isoform X1 [KO:K00901] [EC:2.7.1.107]
116707143  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
116694522  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
116688501  diacylglycerol kinase alpha-like isoform X1 [KO:K00901] [EC:2.7.1.107]
116688994  dgkh; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
116689865  LOW QUALITY PROTEIN: diacylglycerol kinase beta-like [KO:K00901] [EC:2.7.1.107]
116690316  phosphatidate cytidylyltransferase 2-like [KO:K00981] [EC:2.7.7.41]
116690059  phosphatidate cytidylyltransferase 2-like [KO:K00981] [EC:2.7.7.41]
116687305  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
116687772  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116694480  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116670566  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116702478  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116705456  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116703070  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116691362  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
116705744  calm2; calmodulin-2 [KO:K02183]
116678688  calm3; calmodulin-3 [KO:K02183]
116706189  calm1; calmodulin-1 [KO:K02183]
116670661  calmodulin-1 [KO:K02183]
116687887  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
116688267  calml4; calmodulin-like protein 4 [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
esp04020  Calcium signaling pathway
esp04144  Endocytosis
esp04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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