KEGG   PATHWAY: esp04020
Entry
esp04020                    Pathway                                
Name
Calcium signaling pathway - Etheostoma spectabile (orangethroat darter)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
esp04020  Calcium signaling pathway
esp04020

Other DBs
GO: 0019722
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116705122  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
116678284  sodium/calcium exchanger 1-like [KO:K05849]
116699948  sodium/calcium exchanger 1-like [KO:K05849]
116700144  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
116707095  sodium/calcium exchanger 1-like [KO:K05849]
116669705  slc8a3; LOW QUALITY PROTEIN: sodium/calcium exchanger 3 [KO:K05849]
116672716  LOW QUALITY PROTEIN: sodium/calcium exchanger 2-like [KO:K05849]
116673450  atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
116693205  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
116693714  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
116687420  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116688592  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
116672311  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
116705452  muscarinic acetylcholine receptor M3-like [KO:K04131]
116671519  muscarinic acetylcholine receptor M3-like [KO:K04131]
116706059  muscarinic acetylcholine receptor M5-like [KO:K04133]
116669997  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
116704484  adenosine receptor A2a-like [KO:K04266]
116686678  adenosine receptor A2a-like [KO:K04266]
116689814  adenosine receptor A2a-like [KO:K04266]
116700558  adora2b; adenosine receptor A2b [KO:K04267]
116671621  adrb1; beta-1 adrenergic receptor [KO:K04141]
116697150  beta-2 adrenergic receptor-like [KO:K04142]
116686749  beta-2 adrenergic receptor-like [KO:K04142]
116700756  beta-2 adrenergic receptor-like [KO:K04142]
116690197  beta-1 adrenergic receptor-like [KO:K04143]
116706970  D(1) dopamine receptor-like [KO:K04144]
116700711  D(1)-like dopamine receptor [KO:K04144]
116696641  D(1) dopamine receptor-like [KO:K04144]
116705466  D(1)-like dopamine receptor [KO:K05840]
116688155  D(1B) dopamine receptor-like [KO:K05840]
116700993  histamine H2 receptor-like [KO:K04150]
116696825  histamine H2 receptor-like [KO:K04150]
116704509  5-hydroxytryptamine receptor 4-like [KO:K04160]
116699417  5-hydroxytryptamine receptor 4-like [KO:K04160]
116696546  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116672419  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
116692505  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116705189  5-hydroxytryptamine receptor 7-like [KO:K04163]
116690047  5-hydroxytryptamine receptor 7-like [KO:K04163]
116693014  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
116688614  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
116698856  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116699106  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
116695549  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
116690645  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
116701410  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116699442  LOW QUALITY PROTEIN: adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
116706561  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
116686433  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
116693865  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116698871  adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116705853  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
116706628  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
116702848  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116698669  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116695686  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116703683  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116673783  pln; cardiac phospholamban [KO:K05852]
116686953  sln; sarcolipin [KO:K22642]
116704710  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
116700090  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116686654  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
116694637  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
116671274  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
116689300  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
116703734  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
116671307  stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
116669409  stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
116695124  stromal interaction molecule 2-like isoform X1 [KO:K18196]
116700207  protein orai-2-like [KO:K16057]
116672836  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
116692928  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
116687621  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
116692878  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
116692230  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116703362  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
116704759  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
116689195  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
116698956  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
116695425  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
116671117  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116702472  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
116703434  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
116692630  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
116701659  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
116702240  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
116696326  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
116704245  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116689905  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
116702658  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116702974  glutamate receptor ionotropic, NMDA 2B-like isoform X1 [KO:K05210]
116703511  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116671409  glutamate receptor ionotropic, NMDA 2C-like isoform X1 [KO:K05211]
116703438  grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
116691483  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
116701842  uncharacterized protein LOC116701842 [KO:K05212]
116704272  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
116670145  glutamate receptor ionotropic, NMDA 3B-like isoform X1 [KO:K05214]
116700088  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
116689801  p2rx2; P2X purinoceptor 2 [KO:K05216]
116694700  P2X purinoceptor 3-like [KO:K05217]
116696336  P2X purinoceptor 3-like isoform X1 [KO:K05217]
116689091  P2X purinoceptor 4-like [KO:K05218]
116685645  P2X purinoceptor 5-like isoform X1 [KO:K05219]
116700748  P2X purinoceptor 5-like isoform X1 [KO:K05219]
116689166  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
116700122  ryanodine receptor 1-like isoform X1 [KO:K04961]
116672230  ryanodine receptor 1-like isoform X1 [KO:K04961]
116705063  LOW QUALITY PROTEIN: ryanodine receptor 2-like [KO:K04962]
116671584  ryr2; ryanodine receptor 2 [KO:K04962]
116706056  ryanodine receptor 3-like isoform X1 [KO:K04963]
116669685  ryanodine receptor 3-like isoform X1 [KO:K04963]
116706097  microtubule-associated protein futsch-like [KO:K23449]
116699484  calsequestrin-1-like isoform X1 [KO:K23468]
116706934  calsequestrin-1-like isoform X1 [KO:K23468]
116673832  calsequestrin-2-like [KO:K23445]
116697942  calsequestrin-2-like isoform X1 [KO:K23445]
116697199  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
116694648  muscarinic acetylcholine receptor M2-like [KO:K04130]
116673037  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
116686642  alpha-1A adrenergic receptor-like [KO:K04135]
116703872  alpha-1A adrenergic receptor-like [KO:K04135]
116697412  adra1b; alpha-1B adrenergic receptor [KO:K04136]
116699331  adra1d; alpha-1D adrenergic receptor [KO:K04137]
116672342  agtr1; type-1 angiotensin II receptor [KO:K04166]
116679404  endothelin-1 receptor-like [KO:K04197]
116703024  ednra; endothelin-1 receptor [KO:K04197]
116697110  endothelin receptor type B-like [KO:K04198]
116698370  endothelin receptor type B-like [KO:K04198]
116698765  endothelin receptor type B-like [KO:K04198]
116689616  f2r; proteinase-activated receptor 1 [KO:K03914]
116704193  proteinase-activated receptor 1-like [KO:K03914]
116705868  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
116670337  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
116679383  grm5; metabotropic glutamate receptor 5 [KO:K04604]
116700241  metabotropic glutamate receptor 5-like [KO:K04604]
116697810  gastrin-releasing peptide receptor-like [KO:K04169]
116672441  gastrin-releasing peptide receptor-like [KO:K04169]
116687428  hrh1; histamine H1 receptor [KO:K04149]
116707299  5-hydroxytryptamine receptor 2C-like [KO:K04157]
116687410  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
116695297  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
116705600  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
116692622  ntsr1; neurotensin receptor type 1 [KO:K04211]
116688248  isotocin receptor-like [KO:K04229]
116688398  oxtr; oxytocin receptor [KO:K04229]
116694486  avpr1a; vasopressin V1a receptor [KO:K04226]
116673013  arg8-vasotocin receptor-like [KO:K04226]
116673250  arg8-vasotocin receptor-like [KO:K04226]
116699618  LOW QUALITY PROTEIN: leukotriene B4 receptor 1-like [KO:K04297]
116670503  ptafr; platelet-activating factor receptor [KO:K04279]
116702258  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
116696509  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
116703684  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
116695959  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
116695848  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
116670204  B1 bradykinin receptor-like [KO:K03916]
116670266  B2 bradykinin receptor-like isoform X1 [KO:K03916]
116670535  B2 bradykinin receptor-like [KO:K03916]
116670536  B2 bradykinin receptor-like [KO:K03916]
116686202  substance-P receptor-like [KO:K04222]
116686650  substance-P receptor-like [KO:K04222]
116689714  substance-P receptor-like [KO:K04222]
116687398  tacr2; substance-K receptor [KO:K04223]
116699381  tacr3; neuromedin-K receptor [KO:K04224]
116699406  neuromedin-K receptor-like [KO:K04224]
116696003  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
116691639  thyrotropin-releasing hormone receptor-like [KO:K04282]
116679125  thyrotropin-releasing hormone receptor-like [KO:K04282]
116692076  thyrotropin-releasing hormone receptor-like [KO:K04282]
116701942  thyrotropin-releasing hormone receptor-like [KO:K04282]
116673827  cholecystokinin receptor-like [KO:K04194]
116698036  cholecystokinin receptor-like [KO:K04194]
116707112  cckar; cholecystokinin receptor type A [KO:K04194]
116698207  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
116698735  C-X-C chemokine receptor type 4-like [KO:K04189]
116704803  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
116689828  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116670588  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
116695435  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
116689829  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
116695151  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
116696510  egf; pro-epidermal growth factor [KO:K04357]
116688024  protransforming growth factor alpha-like [KO:K08774]
116700400  platelet-derived growth factor subunit A-like [KO:K04359]
116703151  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116700940  myb-like protein Q isoform X1 [KO:K17386]
116683329  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116696522  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
116700286  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116696922  fibroblast growth factor 1-like [KO:K18496]
116696412  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116673308  fgf6; fibroblast growth factor 6 isoform X1 [KO:K04358]
116690260  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116690326  fgf5; fibroblast growth factor 5 [KO:K04358]
116704545  fibroblast growth factor 10-like [KO:K04358]
116698137  fibroblast growth factor 4A-like [KO:K04358]
116705361  fgf7; fibroblast growth factor 7 [KO:K04358]
116698585  fibroblast growth factor 20-like [KO:K04358]
116686512  fibroblast growth factor 8 isoform X1 [KO:K04358]
116696132  fibroblast growth factor 10-like [KO:K04358]
116703304  fgf3; fibroblast growth factor 3 [KO:K04358]
116703305  fgf4; fibroblast growth factor 4 [KO:K04358]
116696380  fibroblast growth factor 8-like isoform X1 [KO:K04358]
116696408  fibroblast growth factor 18-like isoform X1 [KO:K04358]
116696497  fibroblast growth factor 20-like [KO:K04358]
116696607  fibroblast growth factor 4-like [KO:K04358]
116689662  fgf10; fibroblast growth factor 10 [KO:K04358]
116696858  fibroblast growth factor 8b-like [KO:K04358]
116696921  fgf16; fibroblast growth factor 16 [KO:K04358]
116703389  fgf19; fibroblast growth factor 19 [KO:K22603]
116671255  fibroblast growth factor 21-like isoform X1 [KO:K22429]
116673300  fgf23; fibroblast growth factor 23 [KO:K22428]
116697380  vegfb; vascular endothelial growth factor B [KO:K05448]
116706224  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
116699327  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
116673735  vascular endothelial growth factor C-like [KO:K05449]
116702284  vegfc; vascular endothelial growth factor C [KO:K05449]
116672012  vegfd; vascular endothelial growth factor D [KO:K05449]
116692451  nerve growth factor-like [KO:K02582]
116688351  nerve growth factor-like [KO:K02582]
116694689  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116673226  hepatocyte growth factor-like isoform X1 [KO:K05460]
116688658  hepatocyte growth factor-like protein [KO:K23441]
116690250  glial cell line-derived neurotrophic factor-like [KO:K05452]
116704489  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116671269  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116692233  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
116688361  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116673917  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116698166  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116696884  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116690381  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
116687052  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
116694007  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116671913  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
116695713  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116701103  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
116697253  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
116672533  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
116697226  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116695590  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116691144  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116704792  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
116688894  ntrk2; LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
116694048  LOW QUALITY PROTEIN: NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
116694555  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
116693711  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116687309  mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
116687976  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
116683575  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116670530  uncharacterized protein LOC116670530 [KO:K10785]
116673665  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
116698222  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
116698924  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116671514  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116702768  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
116672481  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
116705016  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
116706249  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116706250  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
116686556  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
116670665  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116692557  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116695236  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
116693373  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like isoform X1 [KO:K05859] [EC:3.1.4.11]
116693374  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like isoform X1 [KO:K05859] [EC:3.1.4.11]
116671264  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116694206  plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
116687305  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
116687772  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116694480  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116672165  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
116672166  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
116689292  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
116703489  tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
116706740  mucolipin-1-like isoform X1 [KO:K04992]
116703350  mucolipin-1-like [KO:K04992]
116695943  mcoln2; mucolipin-2 [KO:K04993]
116699806  LOW QUALITY PROTEIN: mucolipin-3-like [KO:K04994]
116695404  mcoln3; mucolipin-3 isoform X1 [KO:K04994]
116691510  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
116705625  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116702787  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
116705162  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116700318  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116705243  voltage-dependent anion-selective channel protein 2 [KO:K15040]
116671390  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
116688940  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
116704016  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
116699755  slc25a4; ADP/ATP translocase 1 [KO:K05863]
116700337  ADP/ATP translocase 2 [KO:K05863]
116696378  ADP/ATP translocase 2-like [KO:K05863]
116705592  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
116671625  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
116681075  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
116692528  troponin C, slow skeletal and cardiac muscles [KO:K05865]
116692304  troponin C, skeletal muscle [KO:K12042]
116692305  troponin C, skeletal muscle-like [KO:K12042]
116705744  calm2; calmodulin-2 [KO:K02183]
116678688  calm3; calmodulin-3 [KO:K02183]
116706189  calm1; calmodulin-1 [KO:K02183]
116670661  calmodulin-1 [KO:K02183]
116687887  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
116688267  calml4; calmodulin-like protein 4 [KO:K02183]
116670983  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
116670988  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
116692177  phkb; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
116669491  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
116687412  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
116671707  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
116699211  LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
116695568  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116702937  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
116692731  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
116687641  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
116687896  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
116688548  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
116672803  camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
116705273  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116686178  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116669783  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
116686615  calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
116671728  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116688857  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116685972  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
116700479  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
116686565  ppp3ca; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
116689519  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
116705038  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
116688324  transcription factor EB-like isoform X1 [KO:K15590]
116691523  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
116701783  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
116692513  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116687593  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
116692552  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116686525  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
116702364  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
116699486  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
116688962  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
116697904  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116698514  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
116685874  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
116687429  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
116673744  LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
116706211  ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
116677535  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116705917  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
116670036  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116696977  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
116700194  inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
116670566  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116702478  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116705456  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116703070  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116691362  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
esp04010  MAPK signaling pathway
esp04070  Phosphatidylinositol signaling system
esp04210  Apoptosis
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system