KEGG   PATHWAY: esp04144
Entry
esp04144                    Pathway                                
Name
Endocytosis - Etheostoma spectabile (orangethroat darter)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
esp04144  Endocytosis
esp04144

Other DBs
GO: 0006897
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116705812  ADP-ribosylation factor 6-like [KO:K07941]
116669894  ADP-ribosylation factor 6 [KO:K07941]
116691384  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116699144  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116701654  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116696108  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116689248  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
116703860  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
116704052  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
116700598  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
116670513  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
116672503  LOW QUALITY PROTEIN: phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
116704360  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
116698595  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
116695420  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
116697990  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
116703659  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
116698566  clta; clathrin light chain A isoform X1 [KO:K04644]
116696863  cltb; clathrin light chain B isoform X1 [KO:K04645]
116679881  clathrin heavy chain 1 isoform X1 [KO:K04646]
116700827  clathrin heavy chain 1-like [KO:K04646]
116689218  cltcl1; clathrin heavy chain 2 isoform X1 [KO:K04646]
116686013  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
116703516  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
116700222  AP-1 complex subunit beta-1 [KO:K11825]
116698842  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
116678701  ap2s1; AP-2 complex subunit sigma [KO:K11827]
116676290  EH domain-containing protein 2-like isoform X1 [KO:K12469]
116678886  EH domain-containing protein 2-like [KO:K12469]
116672244  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
116686746  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
116701720  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
116704718  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
116699000  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
116686196  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
116695846  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
116689665  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116704516  mothers against decapentaplegic homolog 3 [KO:K23605]
116694001  smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
116699220  tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
116671948  transferrin receptor protein 1-like [KO:K06503]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116694007  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116671913  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
116695713  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116701103  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
116694009  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
116694654  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116700199  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
116687126  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
116700422  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
116691238  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K22518] [EC:2.3.2.27]
116671957  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
116699727  endophilin-A2-like isoform X1 [KO:K11247]
116699733  endophilin-A2-like isoform X1 [KO:K11247]
116707092  endophilin-A1-like isoform X1 [KO:K11247]
116694915  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
116702891  endophilin-A3-like isoform X1 [KO:K11247]
116696237  endophilin-A1-like [KO:K11247]
116670548  endophilin-B1-like [KO:K11248]
116672084  endophilin-B1-like [KO:K11248]
116689945  LOW QUALITY PROTEIN: endophilin-B2-like [KO:K21269]
116704055  endophilin-B2-like isoform X1 [KO:K21269]
116674217  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
116697686  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
116678162  amph; amphiphysin isoform X1 [KO:K12562]
116676734  epsin-1-like [KO:K12471]
116676948  nuclear pore complex protein DDB_G0274915-like [KO:K12471]
116676951  LOW QUALITY PROTEIN: epsin-1-like [KO:K12471]
116691550  epsin-1-like isoform X1 [KO:K12471]
116705658  epsin-3-like isoform X1 [KO:K12471]
116702424  epsin-3-like isoform X1 [KO:K12471]
116702459  epn2; epsin-2 isoform X1 [KO:K12471]
116698611  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
116699628  uncharacterized protein LOC116699628 isoform X1 [KO:K12472]
116695118  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
116695814  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
116700111  spart; spartin isoform X1 [KO:K19366]
116671362  spartin-like isoform X1 [KO:K19366]
116688918  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116704410  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116673210  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
116689192  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116692080  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
116692497  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
116687731  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
116700034  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
116702370  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
116703057  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
116672309  LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
116694965  low-density lipoprotein receptor-like isoform X1 [KO:K12473]
116702263  low-density lipoprotein receptor 1-like [KO:K12473]
116681721  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
116706741  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
116706966  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
116670201  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
116701299  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
116704221  dab2; disabled homolog 2 isoform X1 [KO:K12475]
116691720  C-C chemokine receptor type 1-like [KO:K04180]
116673797  C-X-C chemokine receptor type 2-like [KO:K05050]
116687488  C-X-C chemokine receptor type 1-like [KO:K05050]
116688183  C-X-C chemokine receptor type 2-like isoform X1 [KO:K05050]
116698207  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
116698735  C-X-C chemokine receptor type 4-like [KO:K04189]
116697749  rhodopsin kinase GRK1-like [KO:K00909] [EC:2.7.11.14]
116699778  rhodopsin kinase grk7a-like [KO:K00909] [EC:2.7.11.14]
116700094  grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
116700619  rhodopsin kinase GRK1-like [KO:K00909] [EC:2.7.11.14]
116686533  rhodopsin kinase grk7-b-like [KO:K00909] [EC:2.7.11.14]
116678823  beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
116686201  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
116701055  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
116696467  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
116679342  beta-arrestin-1 [KO:K04439]
116707193  arrb2; beta-arrestin-2 [KO:K04439]
116693736  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
116672982  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
116688401  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
116705039  actr2; actin-related protein 2 [KO:K17260]
116707305  actin-related protein 2-like [KO:K17260]
116673892  actin-related protein 3 [KO:K18584]
116697845  actin-related protein 3-like [KO:K18584]
116695030  actin-related protein 2/3 complex subunit 1B-B-like [KO:K05757]
116695039  actin-related protein 2/3 complex subunit 1A [KO:K05757]
116702588  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
116674147  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116704553  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116687761  actin-related protein 2/3 complex subunit 4 [KO:K05755]
116688418  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
116699669  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
116694979  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116705267  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
116701523  WAS/WASL-interacting protein family member 3-like isoform X1 [KO:K19475]
116691017  heat shock cognate 71 kDa protein-like [KO:K03283]
116692861  heat shock 70 kDa protein [KO:K03283]
116700138  heat shock cognate 70 kDa protein [KO:K03283]
116702985  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
116695513  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
116694059  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
116690737  washc5; WASH complex subunit 5 [KO:K18464]
116704933  WASH complex subunit 2-like isoform X1 [KO:K18462]
116694159  washc1; WASH complex subunit 1 [KO:K18461]
116673307  washc3; WASH complex subunit 3 [KO:K18463]
116692324  F-actin-capping protein subunit alpha-1-like [KO:K10364]
116693782  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
116688257  F-actin-capping protein subunit alpha-1 [KO:K10364]
116687694  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
116695800  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
116679762  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
116692773  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
116700156  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
116702783  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
116706269  snx3; sorting nexin-3 [KO:K17918]
116699940  snx12; sorting nexin-12 isoform X1 [KO:K17918]
116688954  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
116690317  stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
116688413  ras-related protein rab7-like [KO:K07897]
116688563  ras-related protein rab7-like [KO:K07897]
116688634  ras-related protein rab7 [KO:K07897]
116702556  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
116698146  signal transducing adapter molecule 2-like [KO:K04705]
116684814  signal transducing adapter molecule 2-like [KO:K04705]
116699801  stam; signal transducing adapter molecule 1 [KO:K04705]
116694260  tumor susceptibility gene 101 protein-like [KO:K12183]
116686883  multivesicular body subunit 12B-like [KO:K12186]
116702731  LOW QUALITY PROTEIN: multivesicular body subunit 12A-like [KO:K12186]
116689975  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
116701385  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
116698416  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37A-like [KO:K12185]
116678385  vacuolar protein sorting-associated protein 37A-like [KO:K12185]
116700977  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
116695548  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
116689522  vps37b; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
116670907  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
116700302  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
116670980  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
116671019  charged multivesicular body protein 6-like [KO:K12195]
116702357  charged multivesicular body protein 6-like isoform X1 [KO:K12195]
116693017  charged multivesicular body protein 4b-like [KO:K12194]
116687625  charged multivesicular body protein 4b [KO:K12194]
116693467  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
116693468  charged multivesicular body protein 4b-like isoform X1 [KO:K12194]
116672358  charged multivesicular body protein 4c-like [KO:K24782]
116670132  chmp3; charged multivesicular body protein 3 [KO:K12193]
116670911  chmp2a; charged multivesicular body protein 2a [KO:K12191]
116698043  chmp2b; charged multivesicular body protein 2b [KO:K12192]
116690389  chmp7; charged multivesicular body protein 7 [KO:K15053]
116699319  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
116693431  vacuolar protein sorting-associated protein 4A [KO:K12196]
116693432  vacuolar protein sorting-associated protein 4A [KO:K12196]
116695619  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
116706810  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
116693459  charged multivesicular body protein 1a [KO:K12197]
116693460  charged multivesicular body protein 1a [KO:K12197]
116700325  chmp1b; charged multivesicular body protein 1b [KO:K12197]
116696876  charged multivesicular body protein 1b-like [KO:K12197]
116698532  charged multivesicular body protein 5 [KO:K12198]
116672458  charged multivesicular body protein 5-like [KO:K12198]
116681764  ist1; IST1 homolog isoform X1 [KO:K19476]
116701762  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
116703174  spg21; maspardin [KO:K19367]
116706008  igf2r; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
116690158  snx2; sorting nexin-2 isoform X1 [KO:K17917]
116694071  snx1; sorting nexin-1 [KO:K17917]
116694278  sorting nexin-1-like [KO:K17917]
116705708  snx5; sorting nexin-5 [KO:K17920]
116687573  sorting nexin-6-like [KO:K17920]
116692732  LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
116687594  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
116694245  hras; GTPase HRas [KO:K02833]
116703789  interleukin-2 receptor subunit beta-like [KO:K05069]
116699939  il2rg; cytokine receptor common subunit gamma [KO:K05070]
116691940  rho-related GTP-binding protein RhoA-C [KO:K04513]
116692018  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
116692455  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
116687703  rho-related GTP-binding protein RhoA-B [KO:K04513]
116688259  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
116704755  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
116676238  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116676239  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116676723  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
116676728  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116676731  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
116676732  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116676733  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116678228  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116678229  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116678230  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116678231  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116678232  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
116678233  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116678826  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
116678968  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116679061  major histocompatibility complex class I-related gene protein-like [KO:K06751]
116679445  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
116687082  folr2; folate receptor beta [KO:K13649]
116702839  riboflavin-binding protein-like [KO:K13649]
116693796  cav1; caveolin-1 [KO:K06278]
116691899  caveolin-2-like [KO:K12958]
116693808  cav2; caveolin-2 [KO:K12958]
116688249  caveolin-2-like [KO:K12958]
116688419  caveolin-2-like [KO:K12958]
116688422  cav3; LOW QUALITY PROTEIN: caveolin-3 [KO:K12959]
116706082  EH domain-containing protein 3 [KO:K12476]
116670225  LOW QUALITY PROTEIN: EH domain-containing protein 4-like [KO:K12477]
116693525  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
116691143  ras-related protein Rab-5A [KO:K07887]
116702199  ras-related protein Rab-5A [KO:K07887]
116688990  ras-related protein Rab-5B-like [KO:K07888]
116671114  ras-related protein Rab-5C-like [KO:K07889]
116703299  rab5c; ras-related protein Rab-5C [KO:K07889]
116700973  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
116692664  rbsn; rabenosyn-5 [KO:K12481]
116690879  rab4a; ras-related protein Rab-4A [KO:K07879]
116691345  rufy2; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 2 [KO:K12482]
116696591  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
116696898  EH domain-containing protein 1-like [KO:K12483]
116697699  sorting nexin-4-like [KO:K17919]
116673146  sorting nexin-4-like [KO:K17919]
116698552  rab31; ras-related protein Rab-31 [KO:K07891]
116688272  rab22a; ras-related protein Rab-22A [KO:K07891]
116706349  rab10; ras-related protein Rab-10 [KO:K07903]
116698592  ras-related protein Rab-8A-like [KO:K07901]
116688027  ras-related protein Rab-26-like [KO:K07901]
116695139  rab8a; ras-related protein Rab-8A [KO:K07901]
116686652  ras-related protein Rab-35 isoform X1 [KO:K07876]
116702296  ras-related protein Rab-35-like [KO:K07876]
116688977  ras-related protein Rab-35 isoform X1 [KO:K07876]
116691692  ras-related protein Rab-11A-like [KO:K07904]
116685768  rab11a; LOW QUALITY PROTEIN: ras-related protein Rab-11A [KO:K07904]
116698906  ras-related protein Rab-11B [KO:K07905]
116695884  ras-related protein Rab-11B [KO:K07905]
116696110  ras-related protein Rab-11B-like [KO:K07905]
116690179  rab11 family-interacting protein 1-like [KO:K12484]
116675705  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
116696447  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
116686091  rab11 family-interacting protein 1-like [KO:K12484]
116704437  zfyve27; protrudin isoform X1 [KO:K19368]
116674014  kif5c; kinesin heavy chain isoform X1 [KO:K10396]
116678291  LOW QUALITY PROTEIN: kinesin heavy chain-like [KO:K10396]
116698783  kinesin-1 heavy chain [KO:K10396]
116692636  kinesin heavy chain-like isoform X1 [KO:K10396]
116684578  kinesin heavy chain-like [KO:K10396]
116687962  kif5a; kinesin heavy chain isoform X1 [KO:K10396]
116671897  kif5b; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
116700841  rab11 family-interacting protein 4B-like isoform X1 [KO:K12485]
116671803  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
116703715  rab11 family-interacting protein 4A-like isoform X1 [KO:K12485]
116699792  partitioning defective 3 homolog isoform X1 [KO:K04237]
116672026  LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
116692610  pard6b; partitioning defective 6 homolog beta [KO:K06093]
116701357  partitioning defective 6 homolog gamma-like isoform X1 [KO:K06093]
116694572  partitioning defective 6 homolog alpha-like [KO:K06093]
116693186  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116698707  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116691327  cell division control protein 42 homolog [KO:K04393]
116692170  cell division control protein 42 homolog isoform X1 [KO:K04393]
116701833  cell division control protein 42 homolog [KO:K04393]
116688288  cell division control protein 42 homolog isoform X1 [KO:K04393]
116701112  smap1; stromal membrane-associated protein 1 [KO:K12486]
116701823  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
116696462  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
116683501  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116688881  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
116703847  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
116669944  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
116670037  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12488]
116688636  LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
116671884  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
116686366  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
116693147  LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
116687588  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
116695278  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
116684041  arap1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
116707279  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
116698553  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
116679823  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
116693274  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
116687213  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
116687304  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
116685780  ADP-ribosylation factor GTPase-activating protein 2-like isoform X1 [KO:K12493]
116685782  ADP-ribosylation factor GTPase-activating protein 2-like isoform X1 [KO:K12493]
116673186  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
116704265  PH and SEC7 domain-containing protein 4-like [KO:K12494]
116685962  PH and SEC7 domain-containing protein 2-like isoform X1 [KO:K12494]
116670886  PH and SEC7 domain-containing protein 1-like [KO:K12494]
116692298  iqsec1; IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
116692798  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
116694152  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
116673165  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
116704728  LOW QUALITY PROTEIN: cytohesin-4-like [KO:K18441]
116691514  cyth2; cytohesin-2 [KO:K18441]
116707110  cytohesin-1-like isoform X1 [KO:K18441]
116671663  cyth3; cytohesin-3 [KO:K18441]
116702701  cytohesin-4-like isoform X1 [KO:K18441]
116702864  cytohesin-1 isoform X1 [KO:K18441]
116671747  cytohesin-1-like isoform X1 [KO:K18441]
116703144  cytohesin-3 isoform X1 [KO:K18441]
116692607  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
116672529  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
116705621  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
116698938  arf1; ADP-ribosylation factor 1 [KO:K07937]
116703282  ADP-ribosylation factor 1-like [KO:K07937]
116692260  arf3; ADP-ribosylation factor 3 [KO:K07938]
116688417  ADP-ribosylation factor 3 [KO:K07938]
116694719  ADP-ribosylation factor 5 [KO:K07939]
116687997  arf4; ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
esp04060  Cytokine-cytokine receptor interaction
esp04070  Phosphatidylinositol signaling system
esp04130  SNARE interactions in vesicular transport
esp04142  Lysosome
esp04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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