KEGG   PATHWAY: esp04144
Entry
esp04144                    Pathway                                
Name
Endocytosis - Etheostoma spectabile (orangethroat darter)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
esp04144  Endocytosis
esp04144

Other DBs
GO: 0006897
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669894  [KO:K07941]
116669944  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
116670037  [KO:K12488]
116670132  chmp3; charged multivesicular body protein 3 [KO:K12193]
116670201  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
116670225  [KO:K12477]
116670513  [KO:K01115] [EC:3.1.4.4]
116670548  [KO:K11248]
116670886  [KO:K12494]
116670907  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
116670911  chmp2a; charged multivesicular body protein 2a [KO:K12191]
116670980  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
116671019  [KO:K12195]
116671114  [KO:K07889]
116671362  [KO:K19366]
116671663  cyth3; cytohesin-3 [KO:K18441]
116671747  [KO:K18441]
116671803  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
116671884  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
116671897  kif5b; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
116671913  [KO:K05093] [EC:2.7.10.1]
116671948  [KO:K06503]
116671957  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
116672026  [KO:K04237]
116672084  [KO:K11248]
116672244  [KO:K04674] [EC:2.7.11.30]
116672309  [KO:K05633] [EC:2.3.2.26]
116672358  [KO:K24782]
116672458  [KO:K12198]
116672503  [KO:K01115] [EC:3.1.4.4]
116672529  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
116672982  [KO:K23612]
116673146  [KO:K17919]
116673165  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
116673186  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
116673210  [KO:K06643] [EC:2.3.2.27]
116673307  washc3; WASH complex subunit 3 [KO:K18463]
116673797  [KO:K05050]
116673892  [KO:K18584]
116674014  kif5c; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
116674147  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116674217  [KO:K12562]
116675705  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
116676238  [KO:K06751]
116676239  [KO:K06751]
116676290  [KO:K12469]
116676723  [KO:K06751]
116676728  [KO:K06751]
116676731  [KO:K06751]
116676732  [KO:K06751]
116676733  [KO:K06751]
116678162  amph; amphiphysin isoform X1 [KO:K12562]
116678228  [KO:K06751]
116678229  [KO:K06751]
116678230  [KO:K06751]
116678231  [KO:K06751]
116678232  [KO:K06751]
116678233  [KO:K06751]
116678291  [KO:K10396] [EC:5.6.1.3]
116678385  [KO:K12185]
116678701  ap2s1; AP-2 complex subunit sigma [KO:K11827]
116678823  [KO:K00910] [EC:2.7.11.15]
116678826  [KO:K06751]
116678886  [KO:K12469]
116678968  [KO:K06751]
116679061  [KO:K06751]
116679342  [KO:K04439]
116679445  [KO:K06751]
116679762  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
116679823  [KO:K17848]
116679881  [KO:K04646]
116681721  [KO:K12474]
116681764  ist1; IST1 homolog isoform X1 [KO:K19476]
116683501  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116684041  arap1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
116684578  [KO:K10396] [EC:5.6.1.3]
116684814  [KO:K04705]
116685768  rab11a; LOW QUALITY PROTEIN: ras-related protein Rab-11A [KO:K07904]
116685780  [KO:K12493]
116685782  [KO:K12493]
116685962  [KO:K12494]
116686013  [KO:K11824]
116686091  [KO:K12484]
116686196  [KO:K04679]
116686201  [KO:K08291] [EC:2.7.11.16]
116686366  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
116686533  [KO:K00909] [EC:2.7.11.14]
116686652  [KO:K07876]
116686746  [KO:K04388] [EC:2.7.11.30]
116686883  [KO:K12186]
116687082  folr2; folate receptor beta [KO:K13649]
116687126  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
116687213  [KO:K17848]
116687304  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
116687488  [KO:K05050]
116687573  [KO:K17920]
116687588  [KO:K12489]
116687594  [KO:K05704] [EC:2.7.10.2]
116687625  [KO:K12194]
116687694  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
116687703  [KO:K04513]
116687731  [KO:K05632] [EC:2.3.2.26]
116687761  [KO:K05755]
116687962  kif5a; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
116687997  arf4; ADP-ribosylation factor 4 [KO:K07939]
116688183  [KO:K05050]
116688249  [KO:K12958]
116688257  [KO:K10364]
116688259  [KO:K04513]
116688272  rab22a; ras-related protein Rab-22A [KO:K07891]
116688288  [KO:K04393]
116688401  [KO:K23612]
116688413  [KO:K07897]
116688417  [KO:K07938]
116688418  [KO:K05755]
116688419  [KO:K12958]
116688422  cav3; LOW QUALITY PROTEIN: caveolin-3 [KO:K12959]
116688563  [KO:K07897]
116688634  [KO:K07897]
116688636  [KO:K12488]
116688881  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
116688918  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116688954  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
116688977  [KO:K07876]
116688990  [KO:K07888]
116689192  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116689218  cltcl1; clathrin heavy chain 2 isoform X1 [KO:K04646]
116689248  [KO:K00889] [EC:2.7.1.68]
116689522  vps37b; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
116689665  [KO:K04500]
116689945  [KO:K21269]
116689975  [KO:K12186]
116690158  snx2; sorting nexin-2 isoform X1 [KO:K17917]
116690179  [KO:K12484]
116690317  stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
116690389  chmp7; charged multivesicular body protein 7 [KO:K15053]
116690737  washc5; WASH complex subunit 5 [KO:K18464]
116690879  rab4a; ras-related protein Rab-4A [KO:K07879]
116691017  [KO:K03283]
116691143  [KO:K07887]
116691238  [KO:K22518] [EC:2.3.2.27]
116691327  [KO:K04393]
116691345  rufy2; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 2 [KO:K12482]
116691384  [KO:K00889] [EC:2.7.1.68]
116691514  cyth2; cytohesin-2 [KO:K18441]
116691550  [KO:K12471]
116691692  [KO:K07904]
116691720  [KO:K04180]
116691899  [KO:K12958]
116691940  [KO:K04513]
116692018  [KO:K04513]
116692080  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
116692170  [KO:K04393]
116692260  arf3; ADP-ribosylation factor 3 [KO:K07938]
116692298  iqsec1; IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
116692324  [KO:K10364]
116692455  [KO:K04513]
116692497  [KO:K05632] [EC:2.3.2.26]
116692607  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
116692610  pard6b; partitioning defective 6 homolog beta [KO:K06093]
116692636  [KO:K10396] [EC:5.6.1.3]
116692664  rbsn; rabenosyn-5 [KO:K12481]
116692732  [KO:K05704] [EC:2.7.10.2]
116692773  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
116692798  [KO:K12495]
116692861  [KO:K03283]
116693017  [KO:K12194]
116693147  [KO:K12489]
116693186  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116693274  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
116693431  [KO:K12196]
116693432  [KO:K12196]
116693459  [KO:K12197]
116693460  [KO:K12197]
116693467  [KO:K12194]
116693468  [KO:K12194]
116693525  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
116693736  [KO:K23612]
116693782  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
116693796  cav1; caveolin-1 [KO:K06278]
116693808  cav2; caveolin-2 [KO:K12958]
116694001  smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
116694007  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116694009  [KO:K05087] [EC:2.7.10.1]
116694059  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
116694071  snx1; sorting nexin-1 [KO:K17917]
116694152  [KO:K12495]
116694159  washc1; WASH complex subunit 1 [KO:K18461]
116694245  hras; GTPase HRas [KO:K02833]
116694260  [KO:K12183]
116694278  [KO:K17917]
116694572  [KO:K06093]
116694654  [KO:K05087] [EC:2.7.10.1]
116694719  [KO:K07939]
116694915  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
116694965  [KO:K12473]
116694979  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116695030  [KO:K05757]
116695039  [KO:K05757]
116695118  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
116695139  rab8a; ras-related protein Rab-8A [KO:K07901]
116695278  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
116695420  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
116695513  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
116695548  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116695619  [KO:K12196]
116695713  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116695800  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
116695814  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
116695846  [KO:K04679]
116695884  [KO:K07905]
116696108  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116696110  [KO:K07905]
116696237  [KO:K11247]
116696447  [KO:K12484]
116696462  [KO:K12486]
116696467  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
116696591  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
116696863  cltb; clathrin light chain B isoform X1 [KO:K04645]
116696876  [KO:K12197]
116696898  [KO:K12483]
116697686  [KO:K12562]
116697699  [KO:K17919]
116697749  [KO:K00909] [EC:2.7.11.14]
116697845  [KO:K18584]
116697990  [KO:K23484]
116698043  chmp2b; charged multivesicular body protein 2b [KO:K12192]
116698146  [KO:K04705]
116698207  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
116698416  [KO:K12185]
116698532  [KO:K12198]
116698552  rab31; ras-related protein Rab-31 [KO:K07891]
116698553  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
116698566  clta; clathrin light chain A isoform X1 [KO:K04644]
116698592  [KO:K07901]
116698595  [KO:K01528] [EC:3.6.5.5]
116698611  [KO:K12472]
116698707  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116698735  [KO:K04189]
116698783  [KO:K10396] [EC:5.6.1.3]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116698842  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
116698906  [KO:K07905]
116698938  arf1; ADP-ribosylation factor 1 [KO:K07937]
116699000  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
116699144  [KO:K00889] [EC:2.7.1.68]
116699220  tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
116699319  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
116699628  [KO:K12472]
116699669  [KO:K05754]
116699727  [KO:K11247]
116699733  [KO:K11247]
116699778  [KO:K00909] [EC:2.7.11.14]
116699792  [KO:K04237]
116699801  stam; signal transducing adapter molecule 1 [KO:K04705]
116699939  il2rg; cytokine receptor common subunit gamma [KO:K05070]
116699940  snx12; sorting nexin-12 isoform X1 [KO:K17918]
116700034  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
116700094  grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
116700111  spart; spartin isoform X1 [KO:K19366]
116700138  [KO:K03283]
116700156  [KO:K18466]
116700199  [KO:K04707] [EC:2.3.2.27]
116700222  [KO:K11825]
116700302  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
116700325  chmp1b; charged multivesicular body protein 1b [KO:K12197]
116700422  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
116700598  [KO:K01115] [EC:3.1.4.4]
116700619  [KO:K00909] [EC:2.7.11.14]
116700827  [KO:K04646]
116700841  [KO:K12485]
116700973  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
116700977  [KO:K12185]
116701055  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
116701103  [KO:K05095] [EC:2.7.10.1]
116701112  smap1; stromal membrane-associated protein 1 [KO:K12486]
116701299  [KO:K12474]
116701357  [KO:K06093]
116701385  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
116701523  [KO:K19475]
116701654  [KO:K00889] [EC:2.7.1.68]
116701720  [KO:K04388] [EC:2.7.11.30]
116701762  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
116701823  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
116701833  [KO:K04393]
116702199  [KO:K07887]
116702263  [KO:K12473]
116702296  [KO:K07876]
116702357  [KO:K12195]
116702370  [KO:K04678] [EC:2.3.2.26]
116702424  [KO:K12471]
116702459  epn2; epsin-2 isoform X1 [KO:K12471]
116702556  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
116702588  [KO:K05757]
116702701  [KO:K18441]
116702731  [KO:K12186]
116702783  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
116702864  [KO:K18441]
116702891  [KO:K11247]
116702985  [KO:K03283]
116703057  [KO:K04678] [EC:2.3.2.26]
116703144  [KO:K18441]
116703174  spg21; maspardin [KO:K19367]
116703282  [KO:K07937]
116703299  rab5c; ras-related protein Rab-5C [KO:K07889]
116703516  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
116703659  dnm2; dynamin-2 isoform X1 [KO:K23484]
116703715  [KO:K12485]
116703789  [KO:K05069]
116703847  [KO:K12487]
116703860  [KO:K00889] [EC:2.7.1.68]
116704052  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
116704055  [KO:K21269]
116704221  dab2; disabled homolog 2 isoform X1 [KO:K12475]
116704265  [KO:K12494]
116704321  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116704360  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
116704410  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116704437  zfyve27; protrudin isoform X1 [KO:K19368]
116704516  [KO:K23605]
116704553  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116704718  [KO:K04679]
116704728  [KO:K18441]
116704755  [KO:K06751]
116704933  [KO:K18462]
116705039  actr2; actin-related protein 2 [KO:K17260]
116705267  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
116705621  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
116705658  [KO:K12471]
116705708  snx5; sorting nexin-5 [KO:K17920]
116705812  [KO:K07941]
116706008  igf2r; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
116706082  [KO:K12476]
116706269  snx3; sorting nexin-3 [KO:K17918]
116706349  rab10; ras-related protein Rab-10 [KO:K07903]
116706741  [KO:K12474]
116706810  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
116706966  [KO:K12474]
116707092  [KO:K11247]
116707110  [KO:K18441]
116707193  arrb2; beta-arrestin-2 [KO:K04439]
116707279  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
116707305  [KO:K17260]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
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Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
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PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
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Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
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Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
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Histol Histopathol 25:99-112 (2010)
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PMID:16203612
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Pietiainen VM, Marjomaki V, Heino J, Hyypia T
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Viral entry, lipid rafts and caveosomes.
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Ann Med 37:394-403 (2005)
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PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
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PMID:22193161
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Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
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Related
pathway
esp04060  Cytokine-cytokine receptor interaction
esp04070  Phosphatidylinositol signaling system
esp04130  SNARE interactions in vesicular transport
esp04142  Lysosome biogenesis
esp04350  TGF-beta signaling pathway
KO pathway
ko04144   

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