KEGG   PATHWAY: etf04728
Entry
etf04728                    Pathway                                
Name
Dopaminergic synapse - Echinops telfairi (small Madagascar hedgehog)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
etf04728  Dopaminergic synapse
etf04728

Other DBs
GO: 0001963
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101642018  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
101661104  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
101649375  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
101646272  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
101638207  DRD1; D(1A) dopamine receptor [KO:K04144]
101660946  DRD5; D(1B) dopamine receptor [KO:K05840]
101657596  CALY; neuron-specific vesicular protein calcyon isoform X1 [KO:K15493]
101637893  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101654141  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101638553  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101657031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101656124  FOS; proto-oncogene c-Fos [KO:K04379]
101654894  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101650626  neuroendocrine secretory protein 55 [KO:K04632]
101646822  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101646557  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101656771  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101650311  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101653565  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101648900  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
101654666  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101654039  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
101639977  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101648034  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
101662802  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101647230  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101644888  sodium channel protein type 1 subunit alpha [KO:K04833]
101656925  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
101651425  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101655311  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101659681  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101659107  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
101658189  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
101662711  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
101651277  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
101648333  DRD4; D(4) dopamine receptor [KO:K04147]
101658651  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101643144  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101641371  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101660148  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101650965  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101648866  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101664254  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101642783  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101663735  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
115868702  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
115871448  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101643112  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
115871023  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115872076  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869664  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101661086  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115869972  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115873712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101659312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115868780  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869401  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115873058  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115870368  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
115868657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
115871976  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101646564  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
115869515  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115870155  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115872073  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101653350  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101646247  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
115872861  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101646089  DRD2; D(2) dopamine receptor isoform X3 [KO:K04145]
101640070  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
101650408  ARRB2; beta-arrestin-2 [KO:K04439]
101644319  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
101644179  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101657344  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101645417  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101647744  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
101663474  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101662513  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101662642  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101657966  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101659001  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101660860  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101659349  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101651322  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
101655698  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101642174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101641890  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101639916  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101657070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123521985  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101648867  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101644422  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101643115  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101648272  GRIA2; glutamate receptor 2 isoform X7 [KO:K05198]
101661759  GRIA3; glutamate receptor 3 [KO:K05199]
101652216  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101651348  KIF5B; kinesin-1 heavy chain [KO:K10396]
101639531  KIF5C; kinesin heavy chain [KO:K10396]
101650624  KIF5A; kinesin heavy chain isoform X2 [KO:K10396]
101643504  CLOCK; circadian locomoter output cycles protein kaput [KO:K02223] [EC:2.3.1.48]
101654436  ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5 [KO:K02296]
101660195  SLC6A3; LOW QUALITY PROTEIN: sodium-dependent dopamine transporter [KO:K05036]
101652973  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
101652656  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
101652175  COMT; catechol O-methyltransferase isoform X2 [KO:K00545] [EC:2.1.1.6]
101655775  TOMT; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
etf00350  Tyrosine metabolism
etf04020  Calcium signaling pathway
etf04721  Synaptic vesicle cycle
etf04724  Glutamatergic synapse
etf05012  Parkinson disease
KO pathway
ko04728   
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