KEGG   PATHWAY: etf04020
Entry
etf04020                    Pathway                                
Name
Calcium signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
etf04020  Calcium signaling pathway
etf04020

Other DBs
GO: 0019722
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101640703  SLC8A2; sodium/calcium exchanger 2 isoform X2 [KO:K05849]
101650159  SLC8A1; sodium/calcium exchanger 1 isoform X13 [KO:K05849]
101656329  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101638053  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X3 [KO:K05850] [EC:7.2.2.10]
101640649  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
101663487  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101656980  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101641566  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101641017  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101649961  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101649788  ADORA2A; adenosine receptor A2a [KO:K04266]
101651597  ADORA2B; adenosine receptor A2b [KO:K04267]
101640655  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101661554  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101645981  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101638207  DRD1; D(1A) dopamine receptor [KO:K04144]
101660946  DRD5; D(1B) dopamine receptor [KO:K05840]
101656843  HRH2; histamine H2 receptor [KO:K04150]
101646621  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101638675  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101651163  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101638667  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101654894  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101650626  neuroendocrine secretory protein 55 [KO:K04632]
101661014  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101645045  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101646509  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101644952  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101640587  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101652236  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101662031  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101644023  PLN; cardiac phospholamban [KO:K05852]
115872249  SLN; sarcolipin [KO:K22642]
105978472  MRLN; myoregulin [KO:K22643]
101661059  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101639123  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101651580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101652951  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
101653254  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
101657107  STIM2; stromal interaction molecule 2 [KO:K18196]
101641227  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101654503  ORAI2; protein orai-2 [KO:K16057]
101663618  ORAI3; protein orai-3 [KO:K16058]
101656925  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
101651425  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101662493  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101658956  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101655311  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101659681  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101654417  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101659216  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101653041  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101650625  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101656805  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101650392  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101648867  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101644422  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101638487  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101647654  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101652370  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101661372  P2RX1; P2X purinoceptor 1 [KO:K05215]
101650151  P2RX2; P2X purinoceptor 2 [KO:K05216]
101650088  P2RX3; P2X purinoceptor 3 [KO:K05217]
101660262  P2RX4; P2X purinoceptor 4 isoform X2 [KO:K05218]
101662627  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101643153  P2RX6; P2X purinoceptor 6 [KO:K05221]
101639980  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
101646433  RYR1; ryanodine receptor 1 [KO:K04961]
101639879  RYR2; ryanodine receptor 2 [KO:K04962]
101645879  RYR3; ryanodine receptor 3 [KO:K04963]
101652278  TRDN; triadin [KO:K23449]
101649051  CASQ1; calsequestrin-1 [KO:K23468]
101639368  CASQ2; calsequestrin-2 [KO:K23445]
101650909  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
101649691  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101660191  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
101644587  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101661011  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
101639901  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101662191  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101646805  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101639554  EDNRA; endothelin-1 receptor [KO:K04197]
101650653  EDNRB; endothelin receptor type B [KO:K04198]
101652507  F2R; proteinase-activated receptor 1 [KO:K03914]
101644342  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101659445  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101655149  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101646563  HRH1; histamine H1 receptor [KO:K04149]
101655523  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101660797  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
101647368  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101639820  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101644419  NTSR1; neurotensin receptor type 1 [KO:K04211]
101646351  OXTR; oxytocin receptor [KO:K04229]
101640456  AVPR1A; vasopressin V1a receptor [KO:K04226]
101649150  AVPR1B; vasopressin V1b receptor [KO:K04227]
101639060  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
101652395  PTAFR; platelet-activating factor receptor [KO:K04279]
101650300  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101656035  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101653835  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101657267  BDKRB1; B1 bradykinin receptor [KO:K03915]
101662833  BDKRB2; B2 bradykinin receptor [KO:K03916]
101640170  TACR1; substance-P receptor [KO:K04222]
101660757  TACR2; substance-K receptor [KO:K04223]
101641515  TACR3; neuromedin-K receptor [KO:K04224]
101645256  TBXA2R; thromboxane A2 receptor [KO:K04264]
101658791  thyrotropin-releasing hormone receptor-like [KO:K04282]
101639158  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101663878  thyrotropin-releasing hormone receptor-like [KO:K04282]
101651778  CCKAR; cholecystokinin receptor type A [KO:K04194]
101649473  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
101658890  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101637893  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101648105  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101664176  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101660937  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101659761  TGFA; protransforming growth factor alpha [KO:K08774]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101654974  FGF1; fibroblast growth factor 1 [KO:K18496]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101657384  FGF6; fibroblast growth factor 6 [KO:K04358]
101655892  FGF7; fibroblast growth factor 7 [KO:K04358]
101645725  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101658407  FGF3; fibroblast growth factor 3 [KO:K04358]
101654224  FGF20; fibroblast growth factor 20 [KO:K04358]
101659774  FGF18; fibroblast growth factor 18 [KO:K04358]
101641057  FGF9; fibroblast growth factor 9 [KO:K04358]
101645168  FGF16; fibroblast growth factor 16 [KO:K04358]
101649614  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101656763  FGF22; fibroblast growth factor 22 [KO:K04358]
101644233  FGF8; fibroblast growth factor 8 [KO:K04358]
101657770  FGF19; fibroblast growth factor 19 [KO:K22603]
101645758  FGF21; fibroblast growth factor 21 [KO:K22429]
101659280  FGF23; fibroblast growth factor 23 [KO:K22428]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101650383  VEGFB; vascular endothelial growth factor B [KO:K16858]
101664676  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101649959  VEGFC; vascular endothelial growth factor C [KO:K05449]
101658298  NGF; beta-nerve growth factor [KO:K02582]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101638022  MST1; hepatocyte growth factor-like protein isoform X2 [KO:K23441]
101644402  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101647544  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101663176  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101652176  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101658234  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
101644525  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101644075  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101653928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101648303  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101647167  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101654367  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101663738  NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101661143  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
101651034  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101660344  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101648979  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101643603  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101651012  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101644253  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101659910  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101645146  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101654141  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101638553  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101657031  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101650242  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101645230  TPCN1; two pore channel protein 1 [KO:K16896]
101656226  TPCN2; two pore channel protein 2 [KO:K14077]
101658961  MCOLN1; mucolipin-1 [KO:K04992]
101644103  MCOLN2; mucolipin-2 [KO:K04993]
101647809  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101653999  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101647651  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101640880  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101656727  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101653907  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101649902  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101642569  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101638395  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101643848  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101648707  ADP/ATP translocase 2 [KO:K05863]
101655091  ADP/ATP translocase 3 [KO:K05863]
101646088  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101653289  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101649341  ADP/ATP translocase 2-like [KO:K05863]
101642037  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial-like [KO:K09565] [EC:5.2.1.8]
101638230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101649244  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101654143  TNNC2; troponin C, skeletal muscle [KO:K12042]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101638911  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
101638689  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101649142  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
101651797  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101641208  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101654866  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101647217  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101660330  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101647140  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101643172  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
101658184  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101650821  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101662137  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101637982  TFEB; transcription factor EB [KO:K15590]
101641174  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101639478  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101664022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101645262  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101649945  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101657111  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101644765  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101647930  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101654179  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101641281  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101661831  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101646917  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101654969  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101661270  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
etf04010  MAPK signaling pathway
etf04070  Phosphatidylinositol signaling system
etf04210  Apoptosis
etf04720  Long-term potentiation
etf04730  Long-term depression
KO pathway
ko04020   
LinkDB

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