Entry Name Asthma - Felis catus (domestic cat)
Description Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Felis catus (domestic cat) [GN:
fca ]
Gene 101088996 DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752 ]
101098301 DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752 ]
111556169 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101082906 HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752 ]
101084108 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
101088734 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
111556173 HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752 ]
101090518 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
111560441 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
101090771 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
111560440 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101082653 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
101090265 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
101084962 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
111560443 HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752 ]
111560444 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
111560445 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
111556176 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
111558969 LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
111558970 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
102899262 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101085363 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
101094323 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
101101505 high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
102902259 high affinity immunoglobulin epsilon receptor subunit beta isoform X2 [KO:K08090 ]
102902189 membrane-spanning 4-domains subfamily A member 3-like [KO:K08090 ]
102902042 membrane-spanning 4-domains subfamily A member 3-like [KO:K08090 ]
101089236 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
Compound C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
Reference Authors Busse WW, Lemanske RF Jr.
Title Asthma.
Journal Reference Authors Renauld JC.
Title New insights into the role of cytokines in asthma.
Journal Reference Authors Romagnani S.
Title The role of lymphocytes in allergic disease.
Journal Reference Authors Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC.
Title Immunologic principles of allergic disease.
Journal Reference Authors Conroy DM, Williams TJ.
Title Eotaxin and the attraction of eosinophils to the asthmatic lung.
Journal Reference Authors Effros RM, Nagaraj H.
Title Asthma: new developments concerning immune mechanisms, diagnosis and treatment.
Journal Reference Authors Barnes PJ.
Title Immunology of asthma and chronic obstructive pulmonary disease.
Journal Reference Authors Holgate ST, Polosa R.
Title Treatment strategies for allergy and asthma.
Journal Reference Authors Valenta R.
Title The future of antigen-specific immunotherapy of allergy.
Journal Reference Authors Trivedi SG, Lloyd CM.
Title Eosinophils in the pathogenesis of allergic airways disease.
Journal Reference Authors Heinecke JW.
Title Eosinophil-dependent bromination in the pathogenesis of asthma.
Journal Related fca04060 Cytokine-cytokine receptor interaction
fca04612 Antigen processing and presentation
fca04660 T cell receptor signaling pathway
fca04662 B cell receptor signaling pathway
fca04664 Fc epsilon RI signaling pathway
KO pathway LinkDB All DBs
