KEGG   PATHWAY: gacu04912
Entry
gacu04912                   Pathway                                
Name
GnRH signaling pathway - Gymnodraco acuticeps
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
gacu04912  GnRH signaling pathway
gacu04912

Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117560855  gnrh3; gonadotropin-releasing hormone 3 [KO:K05252]
117561922  gnrh2; progonadoliberin-2 [KO:K05252]
117551201  gnrhr1; gonadotropin releasing hormone receptor 1 [KO:K04280]
117557719  gnrhr4; gonadotropin releasing hormone receptor 4 [KO:K04280]
117557833  putative gonadotropin-releasing hormone II receptor [KO:K04280]
117533008  gonadotropin-releasing hormone II receptor-like [KO:K04280]
117534189  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
117541950  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
117558416  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
117560499  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
117537493  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
117562961  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
117538552  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
117554043  adcy3a; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
117539413  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
117549654  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
117541907  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
117542997  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
117549142  adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
117533794  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117541104  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117548476  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
117561607  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117548428  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
117555105  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117558377  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
117561581  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117535534  atf4b; activating transcription factor 4b [KO:K04374]
117536055  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117543949  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
117537697  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
117550896  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
117540532  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
117550444  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117545410  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117554181  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117554205  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117549938  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117543700  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117551047  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
117545674  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117552612  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
117536300  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
117551852  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117552177  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
117539693  calm1a; calmodulin-1a [KO:K02183]
117554187  calmodulin-1 [KO:K02183]
117549326  calml4a; calmodulin-like protein 4a isoform X1 [KO:K02183]
117544304  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
117551247  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117547272  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
117543393  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117560739  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117548684  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117561994  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117551971  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117556109  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117543783  prkcdb; protein kinase C, delta b isoform X1 [KO:K06068] [EC:2.7.11.13]
117551113  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
117536109  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117541859  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117548197  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117558053  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
117563145  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
117541823  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
117535431  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
117548727  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
117535848  map3k22; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
117536847  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117553527  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117548594  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
117550850  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117532852  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117532885  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117547509  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
117541966  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117562573  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117562577  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117544887  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117542413  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117539757  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117534079  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117558837  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
117537386  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117539537  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117551817  cdc42l; cell division cycle 42, like [KO:K04393]
117545363  cell division control protein 42 homolog [KO:K04393]
117542978  cell division control protein 42 homolog isoform X1 [KO:K04393]
117559500  cell division control protein 42 homolog [KO:K04393]
117536890  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117552371  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
117537936  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117536791  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117532364  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117551262  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117555963  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117557427  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117545557  transcription factor AP-1-like [KO:K04448]
117555214  jun; transcription factor AP-1 [KO:K04448]
117557124  gonadotropin subunit beta-2-like [KO:K08521]
117549964  cga; glycoprotein hormones alpha chain [KO:K08522]
117533772  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
117546892  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
117549196  mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
117539229  mmp14a; matrix metalloproteinase-14a [KO:K07763] [EC:3.4.24.80]
117556619  mmp14b; matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
117556933  hbegfa; heparin-binding EGF-like growth factor a isoform X1 [KO:K08523]
117558498  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117563188  growth factor receptor-bound protein 2 [KO:K04364]
117533890  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117545900  GTPase HRas [KO:K02833]
117544128  zgc:55558; GTPase HRas [KO:K07827]
117545716  kras; GTPase KRas isoform X1 [KO:K07827]
117542983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117538865  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117532733  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117546153  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117544100  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117546425  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117533539  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
117556057  egr1; early growth response protein 1 [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
gacu04010  MAPK signaling pathway
gacu04020  Calcium signaling pathway
gacu04060  Cytokine-cytokine receptor interaction
gacu04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
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