KEGG   PATHWAY: gacu04020
Entry
gacu04020                   Pathway                                
Name
Calcium signaling pathway - Gymnodraco acuticeps
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
gacu04020  Calcium signaling pathway
gacu04020

Other DBs
GO: 0019722
Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117532380  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
117532804  ntrk3a; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
117532857  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
117532930  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117532976  [KO:K04852]
117533085  [KO:K05214]
117533212  [KO:K04362] [EC:2.7.10.1]
117533457  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
117533705  casq1b; calsequestrin-1b [KO:K23468]
117533772  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
117533794  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117533869  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
117534075  [KO:K04266]
117534090  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
117534189  [KO:K04632]
117534260  [KO:K13755] [EC:3.1.4.17]
117534271  [KO:K04854]
117534507  [KO:K05850] [EC:7.2.2.10]
117534701  [KO:K04348] [EC:3.1.3.16]
117534709  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117535102  fgf2; fibroblast growth factor 2 [KO:K18497]
117535109  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
117535285  grin2da; uncharacterized protein grin2da isoform X1 [KO:K05212]
117535332  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117535404  [KO:K04718] [EC:2.7.1.91]
117535418  [KO:K04961]
117535428  [KO:K04358]
117535431  [KO:K04857]
117535492  [KO:K04258]
117535501  [KO:K04992]
117535736  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117535739  cacna1ba; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
117535777  p2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
117535791  [KO:K04194]
117535832  [KO:K04855]
117535850  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
117536109  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117536124  grm5a; LOW QUALITY PROTEIN: glutamate receptor, metabotropic 5a [KO:K04604]
117536300  [KO:K04960]
117536359  [KO:K04348] [EC:3.1.3.16]
117536427  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
117536528  [KO:K04226]
117536628  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
117536788  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
117536932  fgf9; fibroblast growth factor 4A [KO:K04358]
117537087  tacr1a; tachykinin receptor 1a isoform X1 [KO:K04222]
117537192  [KO:K05850] [EC:7.2.2.10]
117537290  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
117537320  [KO:K05460]
117537338  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117537401  camk1gb; calcium/calmodulin-dependent protein kinase IGb isoform X1 [KO:K08794] [EC:2.7.11.17]
117537493  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
117537539  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117537609  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117537644  vegfba; vascular endothelial growth factor A [KO:K05448]
117537646  slc25a5; ADP/ATP translocase 2 [KO:K05863]
117537697  [KO:K04634]
117537754  slc25a4; ADP/ATP translocase 1 [KO:K05863]
117537771  tacr3l; tachykinin receptor 3-like [KO:K04224]
117537798  [KO:K04322]
117537887  grin2bb; LOW QUALITY PROTEIN: glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
117538018  [KO:K04718] [EC:2.7.1.91]
117538036  [KO:K04992]
117538057  [KO:K18196]
117538340  erbb4b; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117538430  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
117538491  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117538550  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117538551  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
117538552  [KO:K08043] [EC:4.6.1.1]
117538696  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117538716  [KO:K04135]
117538959  [KO:K05861] [EC:3.1.4.11]
117539050  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117539070  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
117539175  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
117539223  stim2b; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
117539327  [KO:K05085] [EC:2.7.10.1]
117539576  ngfb; nerve growth factor [KO:K02582]
117539593  [KO:K17332]
117539693  calm1a; calmodulin-1a [KO:K02183]
117539832  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
117539962  [KO:K22429]
117539980  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
117540069  drd1b; dopamine receptor D1b [KO:K04144]
117540091  [KO:K18496]
117540175  [KO:K04142]
117540207  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117540393  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
117540436  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
117540532  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
117540633  [KO:K04197]
117540673  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
117540835  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
117540859  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
117540877  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
117541057  pde1cb; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
117541104  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117541233  tpcn2; two pore calcium channel protein 2 [KO:K14077]
117541399  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
117541484  atp2b3b; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
117541492  tnnc1b; troponin C type 1b (slow) [KO:K05865]
117541519  [KO:K04157]
117541823  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
117541830  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
117541859  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117541950  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
117542175  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
117542198  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
117542348  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
117542480  mcoln3b; mucolipin-3 [KO:K04994]
117542492  adora2aa; adenosine A2a receptor a [KO:K04266]
117542502  [KO:K05210]
117542666  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
117542788  [KO:K04358]
117542812  [KO:K22428]
117542852  pde1ca; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
117543051  tnnc1a; troponin C type 1a (slow) [KO:K05865]
117543213  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117543219  [KO:K00907] [EC:2.7.11.18]
117543243  [KO:K05212]
117543250  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117543350  [KO:K15040]
117543352  adra1d; alpha-1A adrenergic receptor [KO:K04137]
117543393  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
117543397  [KO:K04160]
117543428  [KO:K04144]
117543539  si:ch73-22a13.3; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117543549  [KO:K09565] [EC:5.2.1.8]
117543695  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
117543700  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117543849  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
117543910  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
117543911  [KO:K05095] [EC:2.7.10.1]
117543949  [KO:K04634]
117543966  gna14a; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
117543976  [KO:K16056]
117544131  atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
117544250  tbxa2r; thromboxane A2 receptor [KO:K04264]
117544304  [KO:K04515] [EC:2.7.11.17]
117544408  casq2; calsequestrin-2 [KO:K23445]
117544411  ednrbb; endothelin receptor type B [KO:K04198]
117544559  [KO:K05211]
117544650  unm_hu7910; uncharacterized abhydrolase domain-containing protein DDB_G0269086 isoform X1 [KO:K00476] [EC:1.14.11.16]
117544669  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117544769  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117544771  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117544822  fgf21; fibroblast growth factor 21 [KO:K22429]
117544928  [KO:K23450]
117544931  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117544954  adrb1; beta-1 adrenergic receptor [KO:K04141]
117544977  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117544983  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
117545088  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
117545180  [KO:K04131]
117545182  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
117545188  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
117545233  drd1a; D(1) dopamine receptor [KO:K04144]
117545254  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
117545410  [KO:K05858] [EC:3.1.4.11]
117545421  fgf3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
117545425  fgf19; fibroblast growth factor 19 [KO:K22603]
117545456  fgf4; fibroblast growth factor 4 [KO:K04358]
117545674  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117545684  [KO:K05460]
117545774  [KO:K04130]
117545995  [KO:K02582]
117546127  fgf22; fibroblast growth factor 22 [KO:K04358]
117546213  tpcn1; two pore calcium channel protein 1 [KO:K16896]
117546275  tacr3a; tachykinin receptor 3a [KO:K04224]
117546408  fgf5; fibroblast growth factor 5 [KO:K04358]
117546606  [KO:K05857] [EC:3.1.4.11]
117546679  [KO:K23445]
117546691  [KO:K05449]
117546698  si:dkey-1h24.2; cholecystokinin receptor [KO:K04194]
117546892  [KO:K05871] [EC:2.7.10.2]
117546920  pln; cardiac phospholamban [KO:K05852]
117547272  [KO:K04515] [EC:2.7.11.17]
117547510  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
117547519  tfeb; transcription factor EB isoform X1 [KO:K15590]
117547722  ntsr1; neurotensin receptor type 1 [KO:K04211]
117547730  [KO:K12042]
117547732  tnnc2; troponin C, skeletal muscle [KO:K12042]
117547857  camk1db; calcium/calmodulin-dependent protein kinase 1Db [KO:K08794] [EC:2.7.11.17]
117547950  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
117547987  atp2b2; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
117548068  mst1; hepatocyte growth factor-like protein [KO:K23441]
117548074  [KO:K05100] [EC:2.7.10.1]
117548098  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
117548183  hrh1; histamine H1 receptor [KO:K04149]
117548197  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
117548226  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
117548366  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
117548428  [KO:K04345] [EC:2.7.11.11]
117548445  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
117548476  [KO:K08049] [EC:4.6.1.1]
117548665  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117548684  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117548713  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
117548919  [KO:K05849]
117549079  [KO:K04160]
117549142  adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
117549211  [KO:K04169]
117549259  [KO:K04133]
117549269  ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
117549322  chrna7a; neuronal acetylcholine receptor subunit alpha-7a isoform X1 [KO:K04809]
117549326  calml4a; calmodulin-like protein 4a isoform X1 [KO:K02183]
117549398  vegfd; vascular endothelial growth factor D [KO:K05449]
117549399  fgf7; fibroblast growth factor 7 [KO:K04358]
117549414  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
117549478  [KO:K05857] [EC:3.1.4.11]
117549896  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
117549938  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117549960  [KO:K04133]
117549998  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117550154  [KO:K04963]
117550293  vegfc; vascular endothelial growth factor C [KO:K05449]
117550366  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
117550444  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117550723  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
117550734  fgf20b; fibroblast growth factor 20b [KO:K04358]
117550745  [KO:K04198]
117550748  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
117550874  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
117550877  [KO:K03916]
117550896  [KO:K04635]
117550912  [KO:K04637]
117550972  ptgfr; LOW QUALITY PROTEIN: prostaglandin F2-alpha receptor [KO:K04262]
117551047  [KO:K04958]
117551101  oxtr; LOW QUALITY PROTEIN: oxytocin receptor [KO:K04229]
117551151  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
117551247  [KO:K04515] [EC:2.7.11.17]
117551297  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
117551346  [KO:K08794] [EC:2.7.11.17]
117551429  tacr2; substance-K receptor [KO:K04223]
117551519  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
117551714  [KO:K05219]
117551852  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117551945  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
117551971  [KO:K19662] [EC:2.7.11.13]
117552032  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
117552177  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
117552214  [KO:K04604]
117552256  [KO:K22642]
117552268  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117552298  [KO:K00871] [EC:2.7.11.19]
117552299  [KO:K04348] [EC:3.1.3.16]
117552491  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
117552612  [KO:K04960]
117552942  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
117552948  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
117552991  hrh2b; histamine receptor H2b [KO:K04150]
117553171  [KO:K04856]
117553219  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117553610  egf; pro-epidermal growth factor [KO:K04357]
117553616  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117553822  [KO:K04446]
117553953  [KO:K04809]
117554043  adcy3a; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
117554131  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
117554147  [KO:K05840]
117554181  [KO:K05858] [EC:3.1.4.11]
117554187  [KO:K02183]
117554205  [KO:K05858] [EC:3.1.4.11]
117554482  [KO:K13755] [EC:3.1.4.17]
117554783  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
117554794  [KO:K04160]
117554849  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
117555006  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117555073  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117555105  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117555200  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117555204  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
117555209  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
117555399  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
117555617  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
117555619  ryr1b; LOW QUALITY PROTEIN: ryanodine receptor 1b [KO:K04961]
117555785  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
117555795  [KO:K04150]
117555923  p2rx3a; P2X purinoceptor 3a [KO:K05217]
117555925  [KO:K04809]
117555955  [KO:K04136]
117556016  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
117556043  fgf16; fibroblast growth factor 16 [KO:K04358]
117556048  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117556109  [KO:K19662] [EC:2.7.11.13]
117556190  ednraa; endothelin receptor type Aa [KO:K04197]
117556311  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
117556444  ptafr; platelet-activating factor receptor [KO:K04279]
117556464  bdkrb1; B1 bradykinin receptor [KO:K03916]
117556472  [KO:K03916]
117556473  [KO:K03916]
117556475  [KO:K03916]
117556498  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
117556500  [KO:K05217]
117556582  ednrba; endothelin receptor Ba isoform X1 [KO:K04198]
117556585  [KO:K05857] [EC:3.1.4.11]
117556598  casq1a; calsequestrin-1a [KO:K23468]
117556636  [KO:K04189]
117556701  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
117556724  [KO:K04136]
117556861  [KO:K04169]
117556978  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
117557103  [KO:K04344]
117557247  adora2b; adenosine receptor A2b [KO:K04267]
117557264  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
117557498  orai2; protein orai-2 [KO:K16057]
117557557  [KO:K10785]
117557570  [KO:K04603]
117557876  mcoln3a; mucolipin-3 [KO:K04994]
117558053  [KO:K04853]
117558110  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
117558160  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
117558346  [KO:K04852]
117558354  [KO:K05850] [EC:7.2.2.10]
117558377  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
117558394  [KO:K05850] [EC:7.2.2.10]
117558410  mylk4a; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
117558416  [KO:K08041] [EC:4.6.1.1]
117558498  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117558654  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
117558658  [KO:K05452]
117558681  [KO:K04160]
117558903  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117558923  [KO:K05214]
117559184  [KO:K04358]
117559194  fgf23; fibroblast growth factor 23 [KO:K22428]
117559326  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
117559410  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
117559477  [KO:K04163]
117559539  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b isoform X1 [KO:K04161]
117559731  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
117559855  fgf10b; fibroblast growth factor 10b [KO:K04358]
117560135  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
117560493  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117560499  [KO:K08041] [EC:4.6.1.1]
117560513  mylk4b; LOW QUALITY PROTEIN: myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
117560594  [KO:K01116] [EC:3.1.4.11]
117560739  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117560836  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
117560888  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117560948  chrm3a; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
117561162  adrb3a; LOW QUALITY PROTEIN: adrenoceptor beta 3a [KO:K04143]
117561241  [KO:K04282]
117561290  [KO:K04358]
117561581  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117561607  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117561701  fgf8b; fibroblast growth factor 8b [KO:K04358]
117561906  [KO:K05849]
117561929  drd5a; LOW QUALITY PROTEIN: D(1) dopamine receptor [KO:K05840]
117561994  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117562193  [KO:K04358]
117562351  [KO:K04849]
117562427  [KO:K05853] [EC:7.2.2.10]
117562910  fgfr2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
117562961  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
117563145  [KO:K04853]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
gacu04010  MAPK signaling pathway
gacu04070  Phosphatidylinositol signaling system
gacu04210  Apoptosis
KO pathway
ko04020   

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