KEGG   PATHWAY: gmu04371
Entry
gmu04371                    Pathway                                
Name
Apelin signaling pathway - Girardinichthys multiradiatus (darkedged splitfin)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
gmu04371  Apelin signaling pathway
gmu04371

Other DBs
GO: 0060183
Organism
Girardinichthys multiradiatus (darkedged splitfin) [GN:gmu]
Gene
124870286  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
124874521  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
124865559  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
124879381  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
124865677  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124882389  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
124871401  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124870631  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
124871149  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
124867163  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124870367  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124881823  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124861404  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
124862755  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124864776  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124867768  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
124862895  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124870299  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
124864749  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124873964  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124869187  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124865649  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
124879454  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
124860543  apln; apelin [KO:K05225]
124884009  aplnr2; apelin receptor 2 [KO:K04174]
124878011  aplnra; apelin receptor A [KO:K04174]
124872055  aplnrb; apelin receptor B [KO:K04174]
124883132  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124856710  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
124856802  guanine nucleotide-binding protein G(i) subunit alpha-1-like isoform X1 [KO:K04630]
124857223  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
124867024  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
124856918  gnb1b; guanine nucleotide binding protein (G protein), beta polypeptide 1b [KO:K04536]
124866426  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
124876885  gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
124865298  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a [KO:K07825]
124878786  gnb3b; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b [KO:K07825]
124873929  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
124867238  gnb5b; guanine nucleotide-binding protein subunit beta-5b isoform X1 [KO:K04539]
124881715  gnb5a; guanine nucleotide-binding protein subunit beta-5a [KO:K04539]
124884858  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
124876532  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
124859567  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
124870113  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124864732  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124874370  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124862608  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
124855276  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
124876379  gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
124872242  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124868890  si:ch211-286b5.5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
124870546  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
124864654  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
124873390  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
124862323  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
124863294  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
124863731  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
124869085  gng13a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13a [KO:K04547]
124879710  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
124875550  gngt2b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [KO:K04549]
124877731  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124872425  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
124855466  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
124859357  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124880665  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
124881650  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124882233  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
124856653  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124856805  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
124858594  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124872108  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124876344  ryanodine receptor 1-like [KO:K04961]
124883896  ryr1b; ryanodine receptor 1b [KO:K04961]
124859652  ryr2b; ryanodine receptor 2 [KO:K04962]
124875186  ryr2a; ryanodine receptor 2 [KO:K04962]
124855599  ryanodine receptor 3-like [KO:K04963]
124881804  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
124855816  calm1a; calmodulin-1a [KO:K02183]
124883886  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
124859157  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
124867418  calml4a; calmodulin-like protein 4a [KO:K02183]
124881816  calmodulin-1 [KO:K02183]
124878013  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
124858840  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
124875100  prkcea; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
124865536  slc9a1a; Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
124879676  Na(+)/H(+) exchanger beta-like [KO:K05742]
124876563  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
124883813  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
124876841  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
124859023  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
124880516  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
124868502  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
124855260  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
124875168  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
124863206  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
124870315  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
124865037  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124871629  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
124873397  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124856367  myl2a; myosin regulatory light chain 2a [KO:K10351]
124877393  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
124869979  myl13; myosin, light chain 13 [KO:K12749]
124872314  myosin light chain 4-like [KO:K12750]
124882413  GTPase HRas [KO:K02833]
124863530  GTPase KRas-like isoform X1 [KO:K07827]
124864335  GTPase KRas-like isoform X1 [KO:K07827]
124879131  kras; GTPase KRas isoform X1 [KO:K07827]
124862859  ras-related protein R-Ras2-like [KO:K07830]
124864555  ras-related protein R-Ras2-like [KO:K07830]
124866950  rras2; ras-related protein R-Ras2 [KO:K07830]
124871430  mrasa; ras-related protein M-Ras [KO:K07831]
124866030  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124856513  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124874089  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
124863274  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124864295  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124877799  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124876390  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
124884239  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
124868300  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
124868485  rps6; 40S ribosomal protein S6 [KO:K02991]
124883301  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
124864297  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
124862760  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
124864076  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
124867803  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
124868942  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
124883780  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124858601  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124867765  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124855241  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124867337  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
124876575  early growth response protein 1-like [KO:K09203]
124860819  egr1; early growth response protein 1 [KO:K09203]
124883511  protein jagged-1 isoform X1 [KO:K06052]
124858677  jag1b; protein jagged-1b isoform X1 [KO:K06052]
124862867  neurogenic locus notch homolog protein 2-like [KO:K20995]
124864442  neurogenic locus notch homolog protein 2-like [KO:K20995]
124867399  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
124866948  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
124881257  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
124865978  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
124875036  becn1; beclin-1 [KO:K08334]
124856160  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
124860640  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
124867996  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
124882211  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
124872711  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
124873586  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
124877269  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
124872782  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
124869932  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
124871092  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
124857371  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
124857837  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
124861372  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
124880702  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
124883350  nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
124874625  tfam; transcription factor A, mitochondrial [KO:K11830]
124869411  klf2b; Krueppel-like factor 2b [KO:K17845]
124863873  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
124865514  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
124867716  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
124862371  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
124862732  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
124864591  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
124875331  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
124873458  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
124864287  histone deacetylase 5-like [KO:K11406] [EC:3.5.1.98]
124871203  hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
124861593  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
124862348  histone deacetylase 5-like isoform X1 [KO:K11406] [EC:3.5.1.98]
124884037  mef2aa; myocyte enhancer factor 2aa [KO:K09260]
124874152  mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
124877644  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
124872611  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
124865410  mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
124879005  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
124858107  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
124877669  mothers against decapentaplegic homolog 2 [KO:K04500]
124867172  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
124878113  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
124865538  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
124872337  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
124874988  acta2; actin, aortic smooth muscle [KO:K12313]
124858983  cdh1; cadherin-1 [KO:K05689]
124858984  si:busm1-71b9.3; cadherin-1 [KO:K05689]
124859614  B-cadherin-like [KO:K05689]
124881468  CCN family member 2-like [KO:K06827]
124857672  agtr1b; type-1 angiotensin II receptor [KO:K04166]
124880223  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
124878409  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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pathway
gmu04010  MAPK signaling pathway
gmu04020  Calcium signaling pathway
gmu04140  Autophagy - animal
gmu04150  mTOR signaling pathway
gmu04270  Vascular smooth muscle contraction
gmu04530  Tight junction
KO pathway
ko04371   
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