KEGG   PATHWAY: hhv00590
Entry
hhv00590                    Pathway                                
Name
Arachidonic acid metabolism - Hyaena hyaena (striped hyena)
Class
Metabolism; Lipid metabolism
Pathway map
hhv00590  Arachidonic acid metabolism
hhv00590

Other DBs
GO: 0019369
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120232702  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120244250  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120233754  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120227896  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229741  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229754  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120229818  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
120229820  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229829  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120236132  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120232221  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
120232262  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
120232263  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
120232300  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
120248736  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
120241143  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
120235903  PLB1; LOW QUALITY PROTEIN: phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
120249171  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120226939  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
120248734  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
120230158  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
120230199  PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
120219929  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
120229760  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
120229888  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
120229905  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
120229943  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
120228267  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
120229466  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
120242519  PRXL2B; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
120239114  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
120233009  TBXAS1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
120226456  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
120237855  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
120237198  aldo-keto reductase family 1 member C3 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
120230439  PTGIS; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
120232804  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
120234647  LTA4H; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
120234528  ZADH2; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
120231956  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
120237597  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
120245668  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
120225649  GGT1; glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
120225651  GGT5; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
120242414  GPX4; phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K05361] [EC:1.11.1.12]
120245389  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
120236077  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
120236152  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
120226329  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120227720  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120227630  LOW QUALITY PROTEIN: cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120231410  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
120231419  ALOXE3; hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
120231357  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
120231436  ALOX15B; polyunsaturated fatty acid lipoxygenase ALOX15B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
120243430  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
120230588  cytochrome P450 2C41-like [KO:K07413] [EC:1.14.14.1]
120230589  cytochrome P450 2C41-like isoform X1 [KO:K07413] [EC:1.14.14.1]
120230594  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
120220308  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
120227740  polyunsaturated fatty acid lipoxygenase ALOX15-like [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
hhv00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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