KEGG   PATHWAY: ifu04912
Entry
ifu04912                    Pathway                                
Name
GnRH signaling pathway - Ictalurus furcatus (blue catfish)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
ifu04912  GnRH signaling pathway
ifu04912

Organism
Ictalurus furcatus (blue catfish) [GN:ifu]
Gene
128622635  gnrh2; progonadoliberin-2 [KO:K05252]
128607536  progonadoliberin-1 isoform X1 [KO:K05252]
128620774  gonadotropin-releasing hormone II receptor-like [KO:K04280]
128600721  gonadotropin-releasing hormone II receptor [KO:K04280]
128607672  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
128615855  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
128601211  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
128615257  adcy2b; adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
128605578  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
128612717  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
128616515  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
128608656  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
128618901  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
128602846  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
128601169  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
128624010  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
128603018  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
128610406  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
128613629  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
128600201  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
128601894  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
128616133  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128603931  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128614279  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
128623927  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
128612233  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128612234  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
128612545  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128610148  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
128600874  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
128601576  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
128614771  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
128624999  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
128606629  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
128607949  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
128617159  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
128622369  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
128614966  calglandulin-like [KO:K02183]
128605409  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
128621174  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
128601514  calm1b; calmodulin-1b [KO:K02183]
128602734  calml4a; calmodulin-like protein 4a [KO:K02183]
128622169  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
128604118  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
128620648  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
128609903  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
128616562  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
128605908  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
128599012  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
128615331  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
128625389  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128622033  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128601966  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
128614961  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
128625003  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
128622995  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
128607646  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
128625366  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
128607445  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
128607852  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
128607938  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
128625109  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
128620211  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
128615724  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
128599682  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
128602865  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
128604520  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
128616705  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128606602  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
128607885  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
128623180  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
128623182  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
128619526  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
128608142  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128625232  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
128616920  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
128612474  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
128612599  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
128612600  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
128620941  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
128600995  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
128621830  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
128609232  si:ch211-168k14.2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
128621255  pld1a; LOW QUALITY PROTEIN: phospholipase D1a [KO:K01115] [EC:3.1.4.4]
128599643  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
128603277  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
128603427  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
128619070  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128625020  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128619051  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
128615861  cell division control protein 42 homolog [KO:K04393]
128624979  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128615580  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
128616832  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
128601752  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128622154  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128622257  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128616632  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128605628  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128610446  transcription factor Jun-like [KO:K04448]
128601161  jun; transcription factor AP-1 [KO:K04448]
128603833  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
128604860  lhb; lutropin subunit beta [KO:K08521]
128612732  cga; glycoprotein hormones alpha chain [KO:K08522]
128612220  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
128601246  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
128602888  mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
128609516  mmp14b; matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
128610251  mmp14a; matrix metalloproteinase-14a [KO:K07763] [EC:3.4.24.80]
128622129  hbegfb; heparin-binding EGF-like growth factor b [KO:K08523]
128611952  hbegfa; heparin-binding EGF-like growth factor a [KO:K08523]
128624292  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
128616031  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
128599154  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
128614273  sos1; son of sevenless homolog 1 [KO:K03099]
128618140  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
128602959  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
128618149  kras; GTPase KRas isoform X1 [KO:K07827]
128601824  zgc:55558; GTPase KRas [KO:K07827]
128608137  nras; GTPase NRas [KO:K07828]
128619536  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
128624988  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128606701  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128613746  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
128624239  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
128602235  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128625408  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128608161  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
128611870  egr1; early growth response protein 1 [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
ifu04010  MAPK signaling pathway
ifu04020  Calcium signaling pathway
ifu04060  Cytokine-cytokine receptor interaction
ifu04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
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