Entry Name Bacterial invasion of epithelial cells
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map ko05100 Bacterial invasion of epithelial cells
Ortholog table Orthology K13732 fibronectin-binding protein A
K13733 fibronectin-binding protein B
K13925 plasmin and fibronectin-binding protein A
K13734 fibronectin-binding protein 1
K05689 cadherin 1, type 1, E-cadherin
K13736 Rho GTPase-activating protein 10
K09593 GRB2-associated-binding protein 1
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K04438 C-crk adapter molecule crk
K13708 dedicator of cytokinesis protein 1
K04393 cell division control protein 42
K04392 Ras-related C3 botulinum toxin substrate 1
K23612 neural Wiskott-Aldrich syndrome protein
K05753 WAS protein family, member 1
K05748 WAS protein family, member 2
K17260 actin-related protein 2
K18584 actin-related protein 3
K05757 actin related protein 2/3 complex, subunit 1A/1B
K05758 actin related protein 2/3 complex, subunit 2
K05756 actin related protein 2/3 complex, subunit 3
K05755 actin related protein 2/3 complex, subunit 4
K05754 actin related protein 2/3 complex, subunit 5
K06279 SHC-transforming protein 1
K17447 SHC-transforming protein 2
K17448 SHC-transforming protein 3
K17449 SHC-transforming protein 4
K05726 breast cancer anti-estrogen resistance 1
K13739 secreted effector protein SopD
K13740 secreted effector protein SptP
K13741 guanine nucleotide exchange factor SopE
K13085 phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78 ]
K12785 LEE-encoded effector EspG
K13728 mitotic spindle assembly checkpoint protein MAD2B
K13744 Rho guanine nucleotide exchange factor 26
K07863 Ras homolog gene family, member G
K12366 engulfment and cell motility protein 1
K18985 engulfment and cell motility protein 2
K19241 engulfment and cell motility protein 3
K04513 Ras homolog gene family, member A
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related ko04810 Regulation of actin cytoskeleton
LinkDB All DBs
