Entry
Name
Spliceosome - Monopterus albus (swamp eel)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Monopterus albus (swamp eel) [GN:
malb ]
Gene
109974694 dhx16; LOW QUALITY PROTEIN: putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813 ] [EC:5.6.2.6 ]
109965435 dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815 ] [EC:5.6.2.6 ]
109966897 small nuclear ribonucleoprotein-associated protein B' [KO:K11086 ]
109958208 snrpc; U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095 ]
109960020 tcerg1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
109970212 u2af2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
109970130 poly(U)-binding-splicing factor PUF60-like isoform X1 [KO:K12838 ]
109965937 poly(U)-binding-splicing factor PUF60-like isoform X1 [KO:K12838 ]
109962493 smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839 ]
109972175 cherp; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841 ]
109959419 U2 snRNP-associated SURP motif-containing protein-like isoform X1 [KO:K12842 ]
109961459 u2surp; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
109974614 lsm8; LSM8 homolog, U6 small nuclear RNA associated isoform X1 [KO:K12627 ]
109970179 prpf3; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843 ]
109973132 prpf4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662 ]
109954870 snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
109954944 eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
109963967 snrnp40; LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
109974652 wbp11; LOW QUALITY PROTEIN: WW domain-binding protein 11 [KO:K12866 ]
109971304 crnkl1; LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869 ]
109962613 LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875 ]
109974410 LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875 ]
109958123 hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
109955424 hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
109957718 rbmx; LOW QUALITY PROTEIN: RNA-binding motif protein, X chromosome [KO:K12885 ]
109961509 hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
109972337 heterogeneous nuclear ribonucleoprotein K-like isoform X1 [KO:K12886 ]
109967465 heterogeneous nuclear ribonucleoprotein M-like isoform X1 [KO:K12887 ]
109959250 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890 ]
109972077 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890 ]
109953359 serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891 ]
109958645 serine/arginine-rich splicing factor 4-like isoform X1 [KO:K12893 ]
109956155 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893 ]
109962375 serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893 ]
109969771 serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893 ]
109968181 tra2a; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
109958767 srsf10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
LinkDB
All DBs