KEGG   PATHWAY: malb03040
Entry
malb03040                   Pathway                                
Name
Spliceosome - Monopterus albus (swamp eel)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
malb03040  Spliceosome
malb03040

Other DBs
GO: 0005681
Organism
Monopterus albus (swamp eel) [GN:malb]
Gene
109966798  ddx46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
109974694  dhx16; LOW QUALITY PROTEIN: putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
109965435  dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
109954258  cdc40; pre-mRNA-processing factor 17 [KO:K12816]
109967856  prpf18; pre-mRNA-splicing factor 18 [KO:K12817]
109962770  dhx8; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
109971196  slu7; pre-mRNA-splicing factor SLU7 [KO:K12819]
109961327  dhx15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
109966547  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15-like isoform X1 [KO:K12820] [EC:5.6.2.6]
109966897  small nuclear ribonucleoprotein-associated protein B' [KO:K11086]
109963891  snrpd1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
109960361  snrpd2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
109965651  snrpd3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
109971978  snrpe; small nuclear ribonucleoprotein E [KO:K11097]
109967806  snrpf; small nuclear ribonucleoprotein F [KO:K11098]
109969963  snrpg; small nuclear ribonucleoprotein G [KO:K11099]
109974359  snrpa; U1 small nuclear ribonucleoprotein A [KO:K11091]
109958208  snrpc; U1 small nuclear ribonucleoprotein C isoform X1 [KO:K11095]
109957074  prpf40a; pre-mRNA-processing factor 40 homolog A [KO:K12821]
109962270  LOW QUALITY PROTEIN: RNA-binding protein 25-like [KO:K12822]
109973354  RNA-binding protein 25-like isoform X1 [KO:K12822]
109974630  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
109966282  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
109960020  tcerg1; transcription elongation regulator 1 isoform X1 [KO:K12824]
109952712  fus; RNA-binding protein FUS [KO:K13098]
109970563  RNA-binding protein FUS-like isoform X1 [KO:K13098]
109973813  snrpa1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
109971778  snrpb2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
109954793  sf3a1; splicing factor 3A subunit 1 [KO:K12825]
109969241  sf3a2; splicing factor 3A subunit 2 [KO:K12826]
109963681  sf3a3; splicing factor 3A subunit 3 [KO:K12827]
109972678  sf3b1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
109971456  sf3b2; splicing factor 3B subunit 2 [KO:K12829]
109962532  sf3b3; splicing factor 3B subunit 3 [KO:K12830]
109958720  sf3b4; splicing factor 3B subunit 4 [KO:K12831]
109960643  sf3b5; splicing factor 3B subunit 5 [KO:K12832]
109952871  sf3b6; splicing factor 3B subunit 6 [KO:K12833]
109971838  phf5a; PHD finger-like domain-containing protein 5A [KO:K12834]
109963133  ddx42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
109960505  splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
109965425  splicing factor U2AF 35 kDa subunit-like isoform X1 [KO:K12836]
109962831  splicing factor U2AF 65 kDa subunit-like isoform X1 [KO:K12837]
109970212  u2af2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
109970130  poly(U)-binding-splicing factor PUF60-like isoform X1 [KO:K12838]
109965937  poly(U)-binding-splicing factor PUF60-like isoform X1 [KO:K12838]
109962493  smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
109960891  rbm17; splicing factor 45 [KO:K12840]
109972175  cherp; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
109959419  U2 snRNP-associated SURP motif-containing protein-like isoform X1 [KO:K12842]
109961459  u2surp; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
109963977  rp9; retinitis pigmentosa 9 protein [KO:K19604]
109965740  lsm2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
109972402  lsm3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
109966843  lsm4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
109959970  lsm5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
109955533  lsm6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
109967458  lsm7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
109974614  lsm8; LSM8 homolog, U6 small nuclear RNA associated isoform X1 [KO:K12627]
109970179  prpf3; LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
109973132  prpf4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
109972166  ppih; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
109970198  prpf31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
109969181  snu13; NHP2-like protein 1 [KO:K12845]
109954870  snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
109961597  usp39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
109972116  sart1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
109974236  zmat2; zinc finger matrin-type protein 2 [KO:K12848]
109965227  prpf38a; pre-mRNA-splicing factor 38A [KO:K12849]
109969287  prpf38b; pre-mRNA-splicing factor 38B [KO:K12850]
109954944  eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
109954839  snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
109964667  prpf6; pre-mRNA-processing factor 6 [KO:K12855]
109960215  prpf8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
109963967  snrnp40; LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
109966069  ddx23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
109951693  txnl4a; thioredoxin-like protein 4A [KO:K12859]
109974312  prpf19; LOW QUALITY PROTEIN: pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
109961123  cdc5l; cell division cycle 5-like protein [KO:K12860]
109967217  bcas2; pre-mRNA-splicing factor SPF27 [KO:K12861]
109968213  plrg1; pleiotropic regulator 1 [KO:K12862]
109959514  cwc15; spliceosome-associated protein CWC15 homolog [KO:K12863]
109967211  ctnnbl1; beta-catenin-like protein 1 [KO:K12864]
109953735  heat shock 70 kDa protein 1-like [KO:K03283]
109973094  heat shock cognate 71 kDa protein-like [KO:K03283]
109972024  heat shock cognate 70 kDa protein [KO:K03283]
109972025  heat shock cognate 71 kDa protein-like [KO:K03283]
109967531  heat shock 70 kDa protein 1-like [KO:K03283]
109967559  heat shock 70 kDa protein 1 [KO:K03283]
109971588  heat shock 70 kDa protein-like [KO:K03283]
109971690  heat shock cognate 71 kDa protein-like [KO:K03283]
109966722  pqbp1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
109974652  wbp11; LOW QUALITY PROTEIN: WW domain-binding protein 11 [KO:K12866]
109970541  snw1; SNW domain-containing protein 1 [KO:K06063]
109965890  xab2; pre-mRNA-splicing factor SYF1 [KO:K12867]
109965003  syf2; pre-mRNA-splicing factor SYF2 [KO:K12868]
109971304  crnkl1; LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
109966948  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
109958944  ppil1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
109964931  ppie; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
109967354  ccdc12; coiled-coil domain-containing protein 12 [KO:K12871]
109973149  rbm22; pre-mRNA-splicing factor RBM22 [KO:K12872]
109952665  bud31; protein BUD31 homolog [KO:K12873]
109968026  aqr; intron-binding protein aquarius [KO:K12874]
109962613  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109974410  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109953486  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109965564  rbm8a; RNA-binding protein 8A [KO:K12876]
109965695  magoh; protein mago nashi homolog [KO:K12877]
109955440  thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
109959435  thoc2; THO complex subunit 2 [KO:K12879]
109956685  thoc3; THO complex subunit 3 [KO:K12880]
109956830  THO complex subunit 4-like [KO:K12881]
109958939  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
109956697  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
109961773  nuclear cap-binding protein subunit 2-like [KO:K12883]
109958123  hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
109970759  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
109955424  hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
109952516  heterogeneous nuclear ribonucleoprotein C-like [KO:K12884]
109957718  rbmx; LOW QUALITY PROTEIN: RNA-binding motif protein, X chromosome [KO:K12885]
109961509  hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
109972337  heterogeneous nuclear ribonucleoprotein K-like isoform X1 [KO:K12886]
109967465  heterogeneous nuclear ribonucleoprotein M-like isoform X1 [KO:K12887]
109969807  hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
109959250  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890]
109972077  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1-like [KO:K12890]
109952721  serine/arginine-rich splicing factor 2-like [KO:K12891]
109953359  serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891]
109959009  serine/arginine-rich splicing factor 3-like [KO:K12892]
109964529  serine/arginine-rich splicing factor 3 isoform X1 [KO:K12892]
109958645  serine/arginine-rich splicing factor 4-like isoform X1 [KO:K12893]
109956155  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like [KO:K12893]
109962375  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
109973414  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
109969771  serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893]
109973752  srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
109970796  serine/arginine-rich splicing factor 9-like [KO:K21123]
109957135  tra2b; transformer-2 protein homolog beta isoform X1 [KO:K12897]
109968068  transformer-2 protein homolog alpha-like isoform X1 [KO:K12897]
109968181  tra2a; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
109958767  srsf10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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