KEGG PATHWAY: mcc05330

KEGG

PATHWAY: mcc05330

Entry

mcc05330                    Pathway

Name

Allograft rejection - Macaca mulatta (rhesus monkey)

Description

Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.

Class

Human Diseases; Immune disease

Pathway map

Allograft rejection

Organism

Macaca mulatta (rhesus monkey) [GN:mcc]

Gene

class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]

MAMU-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]

MAMU-A; major histocompatibility complex, class I, A isoform X1 [KO:K06751]

patr class I histocompatibility antigen, B-1 alpha chain-like precursor [KO:K06751]

MAMU-E; major histocompatibility complex, class I, E precursor [KO:K06751]

MAMU-A3; major histocompatibility complex, class I, A isoform X1 [KO:K06751]

LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]

HLA class I histocompatibility antigen, B-46 alpha chain-like precursor [KO:K06751]

MAMU-AG; major histocompatibility complex, class I, AG precursor [KO:K06751]

HLA class I histocompatibility antigen, B-14 alpha chain isoform X7 [KO:K06751]

saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]

class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]

HLA class I histocompatibility antigen, B-14 alpha chain isoform X1 [KO:K06751]

LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]

HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]

LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]

HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]

LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]

HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]

uncharacterized protein LOC710149 [KO:K10784]

LOW QUALITY PROTEIN: uncharacterized protein LOC698785 [KO:K10785]

T cell receptor beta variable 3-1 [KO:K10785]

uncharacterized protein LOC697904 [KO:K10785]

immunoglobulin lambda-1 light chain-like [KO:K10785]

CD80; T-lymphocyte activation antigen CD80 precursor [KO:K05412]

CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]

CD28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470]

IL12A; interleukin-12 subunit alpha [KO:K05406]

IL12B; interleukin-12 subunit beta precursor [KO:K05425]

FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]

FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]

PRF1; perforin-1 [KO:K07818]

GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]

MAMU-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]

MAMU-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]

MAMU-DPB; major histocompatibility complex, class II, DP beta [KO:K06752]

MAMU-DOA; major histocompatibility complex, class II, DO alpha precursor [KO:K06752]

MAMU-DPA; major histocompatibility complex, class II, DP alpha [KO:K06752]

MAMU-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]

MAMU-DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]

MAMU-DQA1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]

MAMU-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]

MAMU-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]

MAMU-DRB5; LOW QUALITY PROTEIN: MHC class II antigen, Mamu-DRB5 [KO:K06752]

HLA class II histocompatibility antigen, DRB1-3 chain [KO:K06752]

HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]

HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]

DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]

IL2; interleukin-2 precursor [KO:K05429]

CD40LG; CD40 ligand [KO:K03161]

CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]

IFNG; interferon gamma precursor [KO:K04687]

TNF; tumor necrosis factor [KO:K03156]

IL4; interleukin-4 precursor [KO:K05430]

IL5; interleukin-5 precursor [KO:K05428]

IL10; interleukin-10 precursor [KO:K05443]

LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-39 [KO:K06856]

immunoglobulin heavy variable 4-4 [KO:K06856]

uncharacterized protein LOC114675805 [KO:K06856]

immunoglobulin heavy variable 4-61 [KO:K06856]

immunoglobulin heavy variable 4-59 [KO:K06856]

uncharacterized protein LOC714419 [KO:K06856]

LOW QUALITY PROTEIN: immunoglobulin heavy variable 4-28 [KO:K06856]

immunoglobulin heavy variable 4-59 [KO:K06856]

immunoglobulin heavy variable 4-38-2 [KO:K06856]

Ig heavy chain V region MOPC 315 isoform X1 [KO:K06856]

immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]

uncharacterized protein LOC114679736 [KO:K06856]

Compound

Nitric oxide

Reference

Authors

Arakelov A, Lakkis FG.

Title

The alloimmune response and effector mechanisms of allograft rejection.

Journal

Semin Nephrol 20:95-102 (2000)

Reference

Authors

Le Moine A, Goldman M, Abramowicz D.

Title

Multiple pathways to allograft rejection.

Journal

Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001

Reference

Authors

Trivedi HL.

Title

Immunobiology of rejection and adaptation.

Journal

Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047

Reference

Authors

Pietra BA.

Title

Transplantation immunology 2003: simplified approach.

Journal

Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6

Reference

Authors

Oka T, Yoshimura N.

Title

Immunosuppression in organ transplantation.

Journal

Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89

Reference

Authors

Sayegh MH.

Title

Why do we reject a graft? Role of indirect allorecognition in graft rejection.

Journal

Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x

Reference

Authors

Benichou G.

Title

Direct and indirect antigen recognition: the pathways to allograft immune rejection.

Journal

Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou

Reference

Authors

Turvey SE, Wood KJ.

Title

Immunobiology of solid organ transplantation.

Journal

Int Surg 84:279-90 (1999)

Reference

Authors

Janeway CA, Travers P, Walport M, Shlomchik MJ.

Title

Immunobiology 6th edition

Journal

Garland Science Publishing (2005)

Reference

Authors

Game DS, Lechler RI.

Title

Pathways of allorecognition: implications for transplantation tolerance.

Journal

Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2

Reference

Authors

Lechler RI, Garden OA, Turka LA.

Title

The complementary roles of deletion and regulation in transplantation tolerance.

Journal

Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002

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KO pathway

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