KEGG   PATHWAY: mcc04662
Entry
mcc04662                    Pathway                                
Name
B cell receptor signaling pathway - Macaca mulatta (rhesus monkey)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
mcc04662  B cell receptor signaling pathway
mcc04662

Other DBs
GO: 0050853
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100424418  [KO:K06512]
100427076  CD72; B-cell differentiation antigen CD72 isoform X1 [KO:K06504]
100428682  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
100429193  [KO:K06512]
100429845  LILRA5; leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
106992276  [KO:K06512]
106992409  LILRB3; LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
106994739  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
106995758  [KO:K06512]
106996003  [KO:K06856]
106999628  [KO:K06856]
114675574  [KO:K06467]
114675805  [KO:K06856]
114679736  [KO:K06856]
574258  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
692336  LILRB4; leukocyte immunoglobulin-like receptor subfamily B member 4 precursor [KO:K06512]
692337  LILRA3; leukocyte immunoglobulin-like receptor subfamily A member 3 precursor [KO:K06512]
692338  LILRA6; leukocyte immunoglobulin-like receptor subfamily A member 6 precursor [KO:K06512]
692340  LILRB1; LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 1 [KO:K06512]
692341  LILRA2; leukocyte immunoglobulin-like receptor subfamily A member 2 precursor [KO:K06512]
692342  LILRA1; leukocyte immunoglobulin-like receptor subfamily A member 1 [KO:K06512]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
695197  LILRA4; leukocyte immunoglobulin-like receptor subfamily A member 4 isoform X1 [KO:K06512]
695256  [KO:K06512]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
696354  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
696892  BLK; tyrosine-protein kinase Blk isoform X1 [KO:K08890] [EC:2.7.10.2]
697687  [KO:K19831]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
698089  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
698553  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698830  HRAS; GTPase HRas [KO:K02833]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702077  FOS; proto-oncogene c-Fos [KO:K04379]
702390  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
702498  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
703000  BTK; tyrosine-protein kinase BTK isoform X2 [KO:K07370] [EC:2.7.10.2]
704102  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
704363  BLNK; B-cell linker protein isoform X2 [KO:K07371]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704961  CD81; CD81 antigen [KO:K06508]
705017  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
705211  CD19; B-lymphocyte antigen CD19 isoform X3 [KO:K06465]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
706955  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
707225  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707977  KRAS; GTPase KRas [KO:K07827]
708233  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709038  DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1 [KO:K12229]
709089  NRAS; GTPase NRas [KO:K07828]
709095  [KO:K19831]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710040  BANK1; B-cell scaffold protein with ankyrin repeats isoform X1 [KO:K26239]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710601  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
714202  CR2; complement receptor type 2 isoform X1 [KO:K04012]
714374  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
714419  [KO:K06856]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714728  CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367]
714869  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716452  JUN; transcription factor AP-1 [KO:K04448]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
717832  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
718218  CD79B; B-cell antigen receptor complex-associated protein beta chain precursor [KO:K06507]
718403  [KO:K06512]
718421  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
720009  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [KO:K12560]
720452  [KO:K06856]
720904  [KO:K06856]
720935  [KO:K06856]
720985  [KO:K06856]
721002  [KO:K06856]
721083  [KO:K06856]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
722190  CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506]
722278  [KO:K06856]
722780  [KO:K06512]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
mcc04010  MAPK signaling pathway
mcc04020  Calcium signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04120  Ubiquitin mediated proteolysis
mcc04151  PI3K-Akt signaling pathway
mcc04610  Complement and coagulation cascades
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko04662   

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