KEGG   PATHWAY: mdo04713
Entry
mdo04713                    Pathway                                
Name
Circadian entrainment - Monodelphis domestica (gray short-tailed opossum)
Description
Circadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhythms are synchronized to environmental cues. In mammals, a master clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and may synchronize circadian oscillators in peripheral tissues. Light signal is the dominant synchronizer for master SCN clock. Downstream from the retina, glutamate and PACAP are released and trigger the activation of signal transduction cascades, including CamKII and nNOS activity, cAMP- and cGMP-dependent protein kinases, and mitogen-activated protein kinase (MAPK). Of non-photic entrainment, important phase shifting capabilities have been found for melatonin, which inhibits light-induced phase shifts through inhibition of adenylate cyclase (AC). Multiple entrainment pathways converge into CREB regulation. In turn, phosphorylated CREB activates clock gene expression.
Class
Organismal Systems; Environmental adaptation
Pathway map
mdo04713  Circadian entrainment
mdo04713

Other DBs
GO: 0009649
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100023485  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
100018255  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
100017355  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
100028018  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
100033038  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100011784  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
100010898  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
100024521  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
100028973  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
100013712  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100017874  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
100014049  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100025596  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100013232  RYR1; ryanodine receptor 1 [KO:K04961]
100028207  RYR2; ryanodine receptor 2 [KO:K04962]
100031570  RYR3; ryanodine receptor 3 [KO:K04963]
100015674  NOS1AP; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [KO:K16513]
100016457  carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein-like [KO:K16513]
100009972  RASD1; ras related dexamethasone induced 1 [KO:K07843]
100013052  GNAI1; G protein subunit alpha i1 [KO:K04630]
100030095  GNAI3; G protein subunit alpha i3 [KO:K04630]
100032986  GNAI2; G protein subunit alpha i2 [KO:K04630]
100015137  GNAO1; G protein subunit alpha o1 [KO:K04534]
100010736  GNB1; G protein subunit beta 1 [KO:K04536]
100017392  GNB2; G protein subunit beta 2 [KO:K04537]
100013759  GNB3; G protein subunit beta 3 [KO:K07825]
100013546  GNB4; G protein subunit beta 4 [KO:K04538]
100031383  GNB5; G protein subunit beta 5 [KO:K04539]
100010452  GNG3; G protein subunit gamma 3 [KO:K04540]
100021132  GNG4; G protein subunit gamma 4 [KO:K04541]
100011015  GNG5; G protein subunit gamma 5 [KO:K04542]
100014687  GNG7; G protein subunit gamma 7 [KO:K04543]
100016961  GNG8; G protein subunit gamma 8 [KO:K04544]
100018189  GNG10; G protein subunit gamma 10 [KO:K04545]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100010184  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
100017439  GNG13; G protein subunit gamma 13 [KO:K04547]
100018838  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
100029673  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
100023645  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
100030019  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
100027109  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
100025553  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
100022037  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
100011462  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
100013888  ADCYAP1; adenylate cyclase activating polypeptide 1 [KO:K05262]
100029808  ADCYAP1R1; ADCYAP receptor type I [KO:K04587]
100021523  GNAS; GNAS complex locus [KO:K04632]
100029582  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100030463  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
100013164  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
100025332  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
100030872  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100013823  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
100026554  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
100013831  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
100018346  ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100032298  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100017038  GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
100027037  GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
100028289  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100024008  GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
100023016  PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
100014568  PRKG2; protein kinase, cGMP-dependent, type II [KO:K19477] [EC:2.7.11.12]
100021421  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
100014450  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100015466  MTNR1B; melatonin receptor 1B [KO:K04286]
100013898  MTNR1A; melatonin receptor 1A [KO:K04285]
100025945  GPR50; G protein-coupled receptor 50 [KO:K04285]
100011605  GNAQ; G protein subunit alpha q [KO:K04634]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100014566  KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997]
100020905  KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999]
100019404  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
100029817  KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002]
100014506  PER1; period circadian clock 1 [KO:K21944]
100022127  PER2; period circadian clock 2 [KO:K02633]
100027169  PER3; period circadian clock 3 [KO:K21945]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
C01598  Melatonin
Reference
PMID:17646042
  Authors
Brown TM, Piggins HD
  Title
Electrophysiology of the suprachiasmatic circadian clock.
  Journal
Prog Neurobiol 82:229-55 (2007)
DOI:10.1016/j.pneurobio.2007.05.002
Reference
PMID:19109992
  Authors
Dickson L, Finlayson K
  Title
VPAC and PAC receptors: From ligands to function.
  Journal
Pharmacol Ther 121:294-316 (2009)
DOI:10.1016/j.pharmthera.2008.11.006
Reference
PMID:20664079
  Authors
Golombek DA, Rosenstein RE
  Title
Physiology of circadian entrainment.
  Journal
Physiol Rev 90:1063-102 (2010)
DOI:10.1152/physrev.00009.2009
Reference
PMID:16217123
  Authors
Dubocovich ML, Markowska M
  Title
Functional MT1 and MT2 melatonin receptors in mammals.
  Journal
Endocrine 27:101-10 (2005)
DOI:10.1385/ENDO:27:2:101
Reference
PMID:20605968
  Authors
Dubocovich ML, Delagrange P, Krause DN, Sugden D, Cardinali DP, Olcese J
  Title
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.
  Journal
Pharmacol Rev 62:343-80 (2010)
DOI:10.1124/pr.110.002832
Reference
PMID:19449447
  Authors
Hardeland R
  Title
Melatonin: signaling mechanisms of a pleiotropic agent.
  Journal
Biofactors 35:183-92 (2009)
DOI:10.1002/biof.23
Reference
PMID:12700026
  Authors
Golombek DA, Ferreyra GA, Agostino PV, Murad AD, Rubio MF, Pizzio GA, Katz ME, Marpegan L, Bekinschtein TA
  Title
From light to genes: moving the hands of the circadian clock.
  Journal
Front Biosci 8:s285-93 (2003)
DOI:10.2741/1038
Reference
PMID:17586087
  Authors
Mertens I, Husson SJ, Janssen T, Lindemans M, Schoofs L
  Title
PACAP and PDF signaling in the regulation of mammalian and insect circadian rhythms.
  Journal
Peptides 28:1775-83 (2007)
DOI:10.1016/j.peptides.2007.05.005
Reference
PMID:15813931
  Authors
Kim DY, Choi HJ, Kim JS, Kim YS, Jeong DU, Shin HC, Kim MJ, Han HC, Hong SK, Kim YI
  Title
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock.
  Journal
Eur J Neurosci 21:1215-22 (2005)
DOI:10.1111/j.1460-9568.2005.03950.x
Reference
PMID:15016477
  Authors
Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA
  Title
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
  Journal
Neurochem Int 44:617-25 (2004)
DOI:10.1016/j.neuint.2003.09.005
Reference
PMID:11294753
  Authors
Ferreyra GA, Golombek DA
  Title
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
  Journal
Am J Physiol Regul Integr Comp Physiol 280:R1348-55 (2001)
DOI:10.1152/ajpregu.2001.280.5.R1348
Reference
PMID:15930378
  Authors
Butcher GQ, Lee B, Cheng HY, Obrietan K
  Title
Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism.
  Journal
J Neurosci 25:5305-13 (2005)
DOI:10.1523/JNEUROSCI.4361-04.2005
Reference
PMID:10446325
  Authors
Hamada T, Niki T, Ziging P, Sugiyama T, Watanabe S, Mikoshiba K, Ishida N
  Title
Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
  Journal
Brain Res 838:131-5 (1999)
DOI:10.1016/S0006-8993(99)01719-9
Reference
PMID:10208575
  Authors
Diaz-Munoz M, Dent MA, Granados-Fuentes D, Hall AC, Hernandez-Cruz A, Harrington ME, Aguilar-Roblero R
  Title
Circadian modulation of the ryanodine receptor type 2 in the SCN of rodents.
  Journal
Neuroreport 10:481-6 (1999)
DOI:10.1097/00001756-199902250-00007
Reference
PMID:11086993
  Authors
Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH
  Title
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
  Journal
Neuron 28:183-93 (2000)
DOI:10.1016/S0896-6273(00)00095-7
Reference
PMID:12573527
  Authors
Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye ST, Fujimori A, Ohhata T, Araki R, Abe M
  Title
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
  Journal
Brain Res Mol Brain Res 110:1-6 (2003)
DOI:10.1016/S0169-328X(02)00543-0
Reference
PMID:17167088
  Authors
Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
  Title
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
  Journal
J Neurosci 26:12984-95 (2006)
DOI:10.1523/JNEUROSCI.4253-06.2006
Related
pathway
mdo04010  MAPK signaling pathway
mdo04710  Circadian rhythm
KO pathway
ko04713   
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