KEGG   PATHWAY: mdo04010
Entry
mdo04010                    Pathway                                
Name
MAPK signaling pathway - Monodelphis domestica (gray short-tailed opossum)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdo04010  MAPK signaling pathway
mdo04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100009767  [KO:K04393]
100009808  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
100009813  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100009868  [KO:K04872]
100010005  [KO:K04407] [EC:2.7.11.1]
100010055  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
100010184  [KO:K04347]
100010225  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
100010246  NGF; nerve growth factor [KO:K02582]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010453  GNA12; G protein subunit alpha 12 [KO:K04346]
100010499  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
100010591  ECSIT; ECSIT signalling integrator [KO:K04405]
100010710  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100010911  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100011123  SRF; serum response factor [KO:K04378]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100011215  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
100011261  PDGFD; platelet derived growth factor D [KO:K05450]
100011462  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
100011507  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
100011564  STMN1; stathmin 1 [KO:K04381]
100011711  [KO:K03283]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100012179  ARRB1; arrestin beta 1 [KO:K04439]
100012224  ATF4; activating transcription factor 4 [KO:K04374]
100012277  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
100012317  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
100012432  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
100012457  ANGPT4; angiopoietin 4 [KO:K05467]
100012479  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
100012499  FGF16; fibroblast growth factor 16 [KO:K04358]
100012692  FGF10; fibroblast growth factor 10 [KO:K04358]
100012746  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100013088  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100013140  MEF2C; myocyte enhancer factor 2C [KO:K04454]
100013191  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
100013272  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100013301  VEGFC; vascular endothelial growth factor C [KO:K05449]
100013346  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
100013388  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
100013684  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
100013724  RASA1; RAS p21 protein activator 1 [KO:K04352]
100013788  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100013791  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100013859  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
100014092  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
100014099  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
100014117  TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
100014272  NTF3; neurotrophin 3 [KO:K04356]
100014281  ELK4; ELK4, ETS transcription factor [KO:K04376]
100014282  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100014283  GDNF; glial cell derived neurotrophic factor [KO:K05452]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100014450  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100014651  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
100014655  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100014659  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
100014690  FGF5; fibroblast growth factor 5 [KO:K04358]
100014835  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
100014847  [KO:K04439]
100014865  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
100014871  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100015032  [KO:K03283]
100015073  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100015312  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
100015385  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
100015395  NRTN; neurturin [KO:K25414]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100015707  EFNA5; ephrin A5 [KO:K05462]
100015796  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
100015968  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
100016023  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
100016052  ARRB2; arrestin beta 2 [KO:K04439]
100016076  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
100016122  HGF; hepatocyte growth factor [KO:K05460]
100016316  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
100016521  EFNA1; ephrin A1 [KO:K05462]
100016835  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
100016872  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100016894  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100016952  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
100017114  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
100017121  MRAS; muscle RAS oncogene homolog [KO:K07831]
100017172  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
100017243  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
100017311  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
100017378  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
100017469  [KO:K05096] [EC:2.7.10.1]
100017495  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100017501  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
100017517  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100017539  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
100017548  TGFB2; transforming growth factor beta 2 [KO:K13376]
100017615  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
100017664  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
100017751  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
100017762  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
100017874  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
100017883  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
100017937  TGFB3; transforming growth factor beta 3 [KO:K13377]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100018106  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100018336  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018494  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
100018684  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100018991  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
100019183  TGFB1; transforming growth factor beta 1 [KO:K13375]
100019202  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100019356  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
100019531  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
100019563  FGF6; fibroblast growth factor 6 [KO:K04358]
100019656  FGF23; fibroblast growth factor 23 [KO:K22428]
100019828  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100019832  TRADD; TNFRSF1A associated via death domain [KO:K03171]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100019975  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100019993  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
100020082  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100020095  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100020184  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
100020540  RASA2; RAS p21 protein activator 2 [KO:K08053]
100020614  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
100020668  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100020686  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100020951  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100021108  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
100021250  EFNA2; ephrin A2 [KO:K05462]
100021295  IGF1; insulin like growth factor 1 [KO:K05459]
100021296  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
100021399  KITLG; KIT ligand [KO:K05461]
100021421  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
100021575  FGF19; fibroblast growth factor 19 [KO:K22603]
100021625  EFNA4; ephrin A4 [KO:K05462]
100021631  FGF4; fibroblast growth factor 4 [KO:K04358]
100021641  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
100021692  FGF3; fibroblast growth factor 3 [KO:K04358]
100021774  NGFR; nerve growth factor receptor [KO:K02583]
100021885  FGF20; fibroblast growth factor 20 [KO:K04358]
100021917  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
100021991  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100022037  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
100022523  [KO:K07828]
100022806  MAX; MYC associated factor X [KO:K04453]
100022894  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100023069  TNF; tumor necrosis factor [KO:K03156]
100023099  CDC42; cell division cycle 42 [KO:K04393]
100023153  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
100023159  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
100023197  FGF1; fibroblast growth factor 1 [KO:K18496]
100023250  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
100023287  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100023400  FGF8; fibroblast growth factor 8 [KO:K04358]
100023576  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100023597  HSPA1A; heat shock 70 kDa protein 1 [KO:K03283]
100023623  PGF; placental growth factor [KO:K16859]
100023701  PDGFC; platelet derived growth factor C [KO:K05450]
100023816  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
100023872  NF1; neurofibromin 1 [KO:K08052]
100023876  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
100023896  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
100023928  FGF9; fibroblast growth factor 9 [KO:K04358]
100023929  EREG; epiregulin [KO:K09784]
100023978  AREG; amphiregulin [KO:K09782]
100024057  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100024136  STK4; serine/threonine kinase 4 [KO:K04411]
100024331  ANGPT1; angiopoietin 1 [KO:K05465]
100024639  FGF22; fibroblast growth factor 22 [KO:K04358]
100024674  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100024718  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
100024738  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
100024859  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
100024870  [KO:K02583]
100025020  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
100025077  MAPT; microtubule associated protein tau [KO:K04380]
100025262  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
100025304  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
100025378  ARTN; artemin [KO:K25415]
100025434  DAXX; death domain associated protein [KO:K02308]
100025486  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
100025553  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
100025727  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100025923  FGF7; fibroblast growth factor 7 [KO:K04358]
100025939  ATF2; activating transcription factor 2 [KO:K04450]
100025950  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
100025970  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
100026024  IL1B; interleukin 1 beta [KO:K04519]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100026364  CD14; CD14 molecule [KO:K04391]
100026735  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100026752  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100026855  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100027215  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100027857  DUSP9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100028017  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100028072  [KO:K05084] [EC:2.7.10.1]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100028103  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
100028129  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
100028312  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
100028411  VEGFB; vascular endothelial growth factor B [KO:K16858]
100028700  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100028850  ANGPT2; angiopoietin 2 [KO:K05466]
100028919  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100028926  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100028943  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100028987  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
100029049  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100029144  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
100029175  [KO:K04871]
100029209  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100029389  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
100029477  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100029852  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100029873  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100029983  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
100029998  [KO:K16342] [EC:3.1.1.4]
100030037  [KO:K16342] [EC:3.1.1.4]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100030111  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100030293  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
100030422  [KO:K04412]
100030474  FGF17; fibroblast growth factor 17 [KO:K04358]
100030479  NTF4; neurotrophin 4 [KO:K12457]
100030633  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
100031074  FGF18; fibroblast growth factor 18 [KO:K04358]
100031101  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100031265  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100031342  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
100031527  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100031591  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
100031728  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
100031803  VEGFD; vascular endothelial growth factor D [KO:K05449]
100031838  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100031897  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
100032065  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100032078  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
100032298  [KO:K04345] [EC:2.7.11.11]
100032344  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100032495  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
100032790  TGFA; transforming growth factor alpha [KO:K08774]
100032797  [KO:K03283]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100033077  CSF1; colony stimulating factor 1 [KO:K05453]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033128  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
100033190  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100033369  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
100617037  ELK1; ELK1, ETS transcription factor [KO:K04375]
100617157  EFNA3; ephrin A3 [KO:K05462]
100617907  FLNA; filamin A [KO:K04437]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100618518  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
100618744  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100619143  EGF; epidermal growth factor [KO:K04357]
100619759  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
100620008  [KO:K04380]
100620032  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103092114  JUND; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
103100712  [KO:K03283]
103103582  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103104450  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103105479  [KO:K04412]
103105940  IL1A; interleukin 1 alpha [KO:K04383]
497248  TP53; tumor protein p53 [KO:K04451]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
554233  BDNF; brain derived neurotrophic factor [KO:K04355]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
654273  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
654275  [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mdo04070  Phosphatidylinositol signaling system
mdo04110  Cell cycle
mdo04115  p53 signaling pathway
mdo04210  Apoptosis
mdo04310  Wnt signaling pathway
mdo04668  TNF signaling pathway
KO pathway
ko04010   

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